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Found 414 with Last Name = 'dice' and Initial = 't'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315107(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14593(3-amino-5-[1-({[(4-carbamimidoylphenyl)methyl]carb...)
Affinity DataIC50:  16nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315120((1S,2S)-2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl...)
Affinity DataIC50:  19nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14535(2-[6-(3-aminophenyl)-5-chloro-2-oxo-3-(propan-2-yl...)
Affinity DataIC50:  20nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14543(2-[6-(3-aminophenyl)-5-chloro-3-(cyclobutylamino)-...)
Affinity DataIC50:  20nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315129(4-(3-(4-fluorophenyl)-5-(piperidin-4-yl)-1H-pyrazo...)
Affinity DataIC50:  25.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315134(4-(5-(1-methylpiperidin-4-yl)-3-(3-(trifluoromethy...)
Affinity DataIC50:  26.5nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibition of coagulation factor XMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Pharmacia

Curated by ChEMBL
LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against coagulation factor X.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315118(4-(3-(4-chlorophenyl)-5-(1-(tetrahydrofuran-3-yl)p...)
Affinity DataIC50:  31nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315131(4-(3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50:  31.6nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315115(2-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50:  35nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315132(4-(3-(3-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50:  39.2nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14563(N-[(4-carbamimidoylphenyl)methyl]-2-{5-chloro-6-et...)
Affinity DataIC50: <40nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14528(2-[6-(3-aminophenyl)-5-chloro-3-(ethylamino)-2-oxo...)
Affinity DataIC50:  40nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14520(N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[...)
Affinity DataIC50: <40nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14519(N-[(4-carbamimidoylphenyl)methyl]-2-(5-chloro-3-{[...)
Affinity DataIC50: <40nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM50133093((R)-N-{(S)-1-[(S)-4-guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against thrombin (IIa).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315133(4-(5-(1-methylpiperidin-4-yl)-3-(4-(trifluoromethy...)
Affinity DataIC50:  40.5nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315104(2-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50:  41nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  42nMAssay Description:Inhibition of tissue coagulation factor VIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM50130063((R)-N-{(S)-1-[(S)-4-Guanidino-1-(thiazole-2-carbon...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity against tissue coagulation factor VII.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315121(4-(3-(4-chlorophenyl)-5-(1-(pyridin-4-ylmethyl)pip...)
Affinity DataIC50:  47nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315114(4-(3-(4-chlorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50:  48nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315127(4-(3-(4-fluorophenyl)-5-(piperidin-3-yl)-1H-pyrazo...)
Affinity DataIC50:  48.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14537(2-[6-(3-aminophenyl)-5-chloro-2-oxo-3-(pentan-3-yl...)
Affinity DataIC50:  50nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315130(4-(3-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1...)
Affinity DataIC50:  54.7nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14526(2-[6-(3-aminophenyl)-5-chloro-3-(methylamino)-2-ox...)
Affinity DataIC50:  60nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14562(N-[(4-carbamimidoylphenyl)methyl]-2-{5-chloro-6-me...)
Affinity DataIC50:  60nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315103(4-(5-(1-methylpiperidin-4-yl)-3-m-tolyl-1H-pyrazol...)
Affinity DataIC50:  67.3nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315110(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50:  68nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315105(4-(3-(4-chlorophenyl)-5-(1-(2-methoxyethyl)piperid...)
Affinity DataIC50:  70nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14583(2-[6-(3-aminophenyl)-5-chloro-2-oxo-3-[(2-phenylet...)
Affinity DataIC50:  70nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315108(4-(3-(4-chlorophenyl)-5-(1-(methylsulfonyl)piperid...)
Affinity DataIC50:  70nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315112(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50:  71nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315113(1-(4-(3-(4-chlorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50:  80nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315102(1-(4-(3-(4-fluorophenyl)-4-(pyridin-4-yl)-1H-pyraz...)
Affinity DataIC50:  82nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315117(1-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50:  88nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315125(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyrazo...)
Affinity DataIC50:  88nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM50130060((R)-N-{(S)-2-(2-fluoro-phenyl)-1-[(S)-4-guanidino-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of tissue coagulation factor VIIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14552(2-[6-(3-aminophenyl)-5-chloro-3-[(3-hydroxypropyl)...)
Affinity DataIC50:  90nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315128(4-(3-(4-fluorophenyl)-5-(1-methylpiperidin-3-yl)-1...)
Affinity DataIC50:  90nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM50130060((R)-N-{(S)-2-(2-fluoro-phenyl)-1-[(S)-4-guanidino-...)
Affinity DataIC50:  90nMAssay Description:Inhibitory activity against tissue coagulation factor VII.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315124(1-(4-(3-(4-chlorophenyl)-4-(pyrimidin-4-yl)-1H-pyr...)
Affinity DataIC50:  94nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315135(4-(5-(1-methylpiperidin-4-yl)-3-p-tolyl-1H-pyrazol...)
Affinity DataIC50:  99.6nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14571(N-[(4-carbamimidoylphenyl)methyl]-2-[5-chloro-6-(4...)
Affinity DataIC50:  100nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14592(N-[(4-carbamimidoylphenyl)methyl]-2-[5-chloro-6-(3...)
Affinity DataIC50:  100nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14533(2-[6-(3-aminophenyl)-3-(butylamino)-5-chloro-2-oxo...)
Affinity DataIC50:  100nMAssay Description:Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50315106(4-(3-(4-chlorophenyl)-5-(1-(3-methoxypropyl)piperi...)
Affinity DataIC50:  106nMAssay Description:Inhibition of p38alpha assessed as gamma-[33P]ATP incorporation by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Pharmacia

LigandPNGBDBM14590(N-[(4-carbamimidoylphenyl)methyl]-2-[5-chloro-6-(3...)
Affinity DataIC50:  110nMAssay Description:Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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