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Found 113 with Last Name = 'dina' and Initial = 'ms'
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16315(6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Affinity DataIC50:  0.840nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16315(6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Affinity DataIC50:  1nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16633(6-[(5-fluoro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Affinity DataIC50:  3nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  4nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16634(6-{[3-methyl-5-(trifluoromethyl)-1-benzofuran-2-]s...)
Affinity DataIC50:  5nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16636(6-[(5-chloro-3-ethyl-1-benzofuran-2-)sulfonyl]-2,3...)
Affinity DataIC50:  6nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302111(CHEMBL572255 | N-(4-chloro-3-(1-methyl-1H-benzo[d]...)
Affinity DataIC50:  9nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302139(CHEMBL570273 | N-(3-(1H-benzo[d]imidazol-2-yl)-4-c...)
Affinity DataIC50:  12nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)
Affinity DataIC50:  13nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16635(6-[(3,5-dimethyl-1-benzofuran-2-)sulfonyl]-2,3-dih...)
Affinity DataIC50:  13nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16638(6-(3-Phenylbenzofuran-2-sulfonyl)-2H-pyridazin-3-o...)
Affinity DataIC50:  23nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16457(6-[(5-chloro-1-benzofuran-2-)sulfonyl]-2,3-dihydro...)
Affinity DataIC50:  25nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16457(6-[(5-chloro-1-benzofuran-2-)sulfonyl]-2,3-dihydro...)
Affinity DataIC50:  25nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16620(6-{[(2-chloro-6-fluorophenyl)methane]sulfonyl}-2,3...)
Affinity DataIC50:  26nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSorbitol dehydrogenase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50102724(4-[2-(1-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-...)
Affinity DataIC50:  27nMAssay Description:In vitro inhibitory activity against human SDHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16640(6-[(5-chloro-3-phenyl-1-benzofuran-2-)sulfonyl]-2,...)
Affinity DataIC50:  34nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16616(6-{[(2,3-dichlorophenyl)methane]sulfonyl}-2,3-dihy...)
Affinity DataIC50:  35nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302138(CHEMBL570712 | N-(4-chloro-3-(pyridin-2-yl)phenyl)...)
Affinity DataIC50:  40nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302123(CHEMBL571353 | N-(4-chloro-3-(pyridin-2-yl)phenyl)...)
Affinity DataIC50:  42nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16622(6-({[2-fluoro-3-(trifluoromethyl)phenyl]methane}su...)
Affinity DataIC50:  44nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16639(6-{[3-(4-fluorophenyl)-1-benzofuran-2-]sulfonyl}-2...)
Affinity DataIC50:  49nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16604(6-[(2,6-dichlorobenzene)sulfonyl]-2,3-dihydropyrid...)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16617(6-{[(2,6-dichlorophenyl)methane]sulfonyl}-2,3-dihy...)
Affinity DataIC50:  52nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302128(CHEMBL570936 | N-(4-chloro-3-(quinoxalin-2-yl)phen...)
Affinity DataIC50:  52nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16621(6-{[(3-chloro-2-fluorophenyl)methane]sulfonyl}-2,3...)
Affinity DataIC50:  54nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16642(6-[(5-chloro-3-methyl-1-benzothiophene-2-)sulfonyl...)
Affinity DataIC50:  55nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16602(6-[(2,3-dichlorobenzene)sulfonyl]-2,3-dihydropyrid...)
Affinity DataIC50:  55nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302113(CHEMBL572005 | N-(3-(benzo[d]thiazol-2-yl)-4-chlor...)
Affinity DataIC50:  70nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16615(6-({[3-(trifluoromethyl)phenyl]methane}sulfonyl)-2...)
Affinity DataIC50:  72nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16603(6-[(2,5-dichlorobenzene)sulfonyl]-2,3-dihydropyrid...)
Affinity DataIC50:  73nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302115(CHEMBL569818 | N-(4-chloro-3-(2H-indazol-2-yl)phen...)
Affinity DataIC50:  80nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16631(6-[(5,7-dichloro-1-benzofuran-2-)sulfonyl]-2,3-dih...)
Affinity DataIC50:  87nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16637(6-{[5-chloro-3-(propan-2-yl)-1-benzofuran-2-]sulfo...)
Affinity DataIC50:  92nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302134(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)benzam...)
Affinity DataIC50:  110nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16612(6-{[(2-chlorophenyl)methane]sulfonyl}-2,3-dihydrop...)
Affinity DataIC50:  118nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302137(CHEMBL570711 | N-(4-chloro-3-(pyridin-2-yl)phenyl)...)
Affinity DataIC50:  120nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302129(CHEMBL570044 | N-(4-chloro-3-(pyridin-2-yl)phenyl)...)
Affinity DataIC50:  130nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16451(6-[(4-bromo-2-fluorobenzene)sulfonyl]-2,3-dihydrop...)
Affinity DataIC50:  140nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302118(CHEMBL571352 | N-(4-chloro-3-(phenylcarbamoyl)phen...)
Affinity DataIC50:  140nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16629(6-(3-Methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-o...)
Affinity DataIC50:  140nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16451(6-[(4-bromo-2-fluorobenzene)sulfonyl]-2,3-dihydrop...)
Affinity DataIC50:  140nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16312((4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-i...)
Affinity DataIC50:  140nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16456(6-(1-benzofuran-2-sulfonyl)-2,3-dihydropyridazin-3...)
Affinity DataIC50:  150nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16455(6-(1-benzothiophene-2-sulfonyl)-2,3-dihydropyridaz...)
Affinity DataIC50:  150nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16456(6-(1-benzofuran-2-sulfonyl)-2,3-dihydropyridazin-3...)
Affinity DataIC50:  150nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302112(CHEMBL583479 | N-(4-chloro-3-(1-methyl-4,5,6,7-tet...)
Affinity DataIC50:  150nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16609(6-(alpha-Naphthylmethylbenzenesulfonyl)-2H-pyridaz...)
Affinity DataIC50:  150nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16641(6-[(5-methyl-1-benzothiophene-2-)sulfonyl]-2,3-dih...)
Affinity DataIC50:  160nMAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM16444(6-[(2-chlorobenzene)sulfonyl]-2,3-dihydropyridazin...)
Affinity DataIC50:  170nMpH: 7.0 T: 2°CAssay Description:The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSonic hedgehog protein(Mus musculus (Mouse))
Genentech

Curated by ChEMBL
LigandPNGBDBM50302114(CHEMBL569817 | N-(4-chloro-3-(pyrazolo[1,5-a]pyrid...)
Affinity DataIC50:  170nMAssay Description:Inhibition of SHH in mouse C3H10T1/2 cells by Gli-luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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