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Target
Sorbitol dehydrogenase
Ligand
BDBM50102724
Substrate
n/a
Meas. Tech.
ChEMBL_198036 (CHEMBL800733)
IC50
27±n/a nM
Citation
 Mylari, BL; Oates, PJ; Beebe, DA; Brackett, NS; Coutcher, JB; Dina, MS; Zembrowski, WJ Sorbitol dehydrogenase inhibitors (SDIs): a new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]piperazine-1-sulfonic acid dimethylamide. J Med Chem 44:2695-700 (2001) [PubMed]  Article 
Target
Name:
Sorbitol dehydrogenase
Synonyms:
DHSO_HUMAN | L-iditol 2-dehydrogenase | SORD
Type:
PROTEIN
Mol. Mass.:
38332.20
Organism:
Homo sapiens (Human)
Description:
ChEMBL_223910
Residue:
357
Sequence:
MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
  
Inhibitor
Name:
BDBM50102724
Synonyms:
4-[2-(1-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1-sulfonic acid dimethylamide | CHEMBL90344
Type:
Small organic molecule
Emp. Form.:
C12H21N5O3S
Mol. Mass.:
315.392
SMILES:
C[C@@H](O)c1nccc(n1)N1CCN(CC1)S(=O)(=O)N(C)C
Structure:
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