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maximum 50k data
Found 47 with Last Name = 'dooley' and Initial = 'dj'
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  14nMAssay Description:Inhibition of Na+ influx in chinese hamster ovary cells expressing rat brain sodium channel type IIAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080037(Benzoic acid 4-((S)-2-{(S)-2-[(4-tert-butyl-benzyl...)
Affinity DataIC50:  36nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50080153((1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(ami...)
Affinity DataIC50:  70nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
LigandPNGBDBM50168499((1-((1H-tetrazol-5-yl)methyl)cycloheptyl)methanami...)
Affinity DataIC50:  100nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50212317((1-((1H-tetrazol-5-yl)methyl)cyclohexyl)methanamin...)
Affinity DataIC50:  108nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080046(Benzoic acid 4-((S)-2-{(S)-2-[(4-bromo-benzyl)-met...)
Affinity DataIC50:  130nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080035(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  230nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080041(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  280nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080040(Benzoic acid 4-{(S)-2-[(S)-2-(benzyl-methyl-amino)...)
Affinity DataIC50:  360nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50017702(1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...)
Affinity DataIC50:  420nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080036(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  500nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080034(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  560nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50076115(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-2...)
Affinity DataIC50:  680nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080042(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080043(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-2...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50369583(CHEMBL452325)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of N-type calcium channel in IMR32 human neuroblastoma cells using fluorescent [Ca2+] indicator Indo-1 in the presence of 5 uM nitrendipin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168498((S)-2-((1H-tetrazol-5-yl)methyl)-4-methylpentan-1-...)
Affinity DataIC50:  1.59E+3nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080044(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-2...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080039(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-4...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080045(Benzoic acid 4-{(S)-2-tert-butylcarbamoyl-2-[(S)-4...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50080038(Benzoic acid 4-((S)-2-tert-butylcarbamoyl-2-{(S)-4...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of N-type calcium channels in IMR-32 human neuroblastoma cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168502((1-((1H-tetrazol-5-yl)methyl)cyclooctyl)methanamin...)
Affinity DataIC50:  2.36E+3nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM23619(2-{4-[4,4-bis(4-fluorophenyl)butyl]piperazin-1-yl}...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043993(CHEMBL282833 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-...)
Affinity DataIC50:  2.70E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044001(CHEMBL93106 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-p...)
Affinity DataIC50:  3.10E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043984(2,2-Bis-(2-chloro-phenyl)-N-[3-(2,6-dimethyl-piper...)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043992(1-[3-(2,6-Dimethyl-piperidin-1-yl)-propyl]-3,3-dip...)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043990(1-Phenyl-cyclohexanecarboxylic acid [3-(2,6-dimeth...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043998(2,2-Bis-(4-chloro-phenyl)-N-[3-(2,6-dimethyl-piper...)
Affinity DataIC50:  4.50E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044000(2,2-Bis-(4-bromo-phenyl)-N-[3-(2,6-dimethyl-piperi...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50168499((1-((1H-tetrazol-5-yl)methyl)cycloheptyl)methanami...)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of potassium-evoked [3H]norepinephrine release from rat neocortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043995(CHEMBL92071 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-p...)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043994(CHEMBL92918 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-p...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent calcium channel subunit alpha-2/delta-1(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50080153((1-Aminomethyl-cyclohexyl)-acetic acid | 2-(1-(ami...)
Affinity DataIC50:  8.90E+3nMAssay Description:Inhibition of potassium-evoked [3H]norepinephrine release from rat neocortexMore data for this Ligand-Target Pair
LigandPNGBDBM50168500((1-(aminomethyl)cyclohexyl)methanesulfinic acid | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168504((1-((1-methyl-1H-tetrazol-5-yl)methyl)cyclohexyl)m...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50168503((1-(aminomethyl)cyclohexyl)methanesulfonic acid | ...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50370711(CHEMBL553199)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]gabapentin from alpha-2delta calcium channel in pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043991(2-Cyclopentyl-N-[3-(2,6-dimethyl-piperidin-1-yl)-p...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043997(9H-Xanthene-9-carboxylic acid [3-(2,6-dimethyl-pip...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043986(CHEMBL329245 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-...)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043996(9H-Fluorene-9-carboxylic acid [3-(2,6-dimethyl-pip...)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043999(CHEMBL93838 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-p...)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043987(3-(3-Dimethylamino-propyl)-5,5-diphenyl-imidazolid...)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043985(CHEMBL93065 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043989(CHEMBL93271 | N-[3-(2,6-Dimethyl-piperidin-1-yl)-p...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50043988(3-[3-(2,6-Dimethyl-piperidin-1-yl)-propyl]-1,1-dip...)
Affinity DataIC50:  1.06E+5nMAssay Description:Inhibition of veratridine-induced Na+ influx in chinese hamster ovary cells expressing alpha subunit of rat brain type voltage-gated sodium channel t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed