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Target
Voltage-dependent calcium channel alpha-2 delta subunit
Ligand
BDBM50168502
Substrate
n/a
Meas. Tech.
ChEMBL_348644 (CHEMBL866258)
IC50
2357±n/a nM
Citation
 Burgos-Lepley, CE; Thompson, LR; Kneen, CO; Osborne, SA; Bryans, JS; Capiris, T; Suman-Chauhan, N; Dooley, DJ; Donovan, CM; Field, MJ; Vartanian, MG; Kinsora, JJ; Lotarski, SM; El-Kattan, A; Walters, K; Cherukury, M; Taylor, CP; Wustrow, DJ; Schwarz, JB Carboxylate bioisosteres of gabapentin. Bioorg Med Chem Lett 16:2333-6 (2006) [PubMed]  Article 
Target
Name:
Voltage-dependent calcium channel alpha-2 delta subunit
Synonyms:
Voltage-dependent calcium channel alpha2delta subunit
Type:
PROTEIN
Mol. Mass.:
123127.66
Organism:
Sus scrofa
Description:
ChEMBL_605546
Residue:
1091
Sequence:
MAAGCLLALTLTLFQSLLIGPSSQEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASNEVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIMLFTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIRINTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSLALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSIADILHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIFGIQCVLLWLLSGSRHYQL
  
Inhibitor
Name:
BDBM50168502
Synonyms:
(1-((1H-tetrazol-5-yl)methyl)cyclooctyl)methanamine | CHEMBL204580
Type:
Small organic molecule
Emp. Form.:
C11H21N5
Mol. Mass.:
223.3179
SMILES:
NCC1(Cc2nnn[nH]2)CCCCCCC1
Structure:
Search PDB for entries with ligand similarity: