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Found 2722 with Last Name = 'du' and Initial = 'f'
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399614(CHEMBL2181170)
Affinity DataKi:  0.0398nMAssay Description:Displacement of radioligand from human 5HT4R by Cerep protocol based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399614(CHEMBL2181170)
Affinity DataKi:  0.0400nMAssay Description:Displacement of radioligand from human 5HT4R by Cerep protocol based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485941(CHEMBL2181004)
Affinity DataKi:  0.0460nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485945(CHEMBL2181003)
Affinity DataKi:  0.0585nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485942(CHEMBL2181002)
Affinity DataKi:  0.0637nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598740(CHEMBL5175227)
Affinity DataKi:  0.120nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485950(CHEMBL2181009)
Affinity DataKi:  0.122nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485944(CHEMBL2181006)
Affinity DataKi:  0.127nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598738(CHEMBL5204065)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598739(CHEMBL5188215)
Affinity DataKi:  0.130nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485943(CHEMBL2181001)
Affinity DataKi:  0.131nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485946(CHEMBL2181000)
Affinity DataKi:  0.143nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598724(CHEMBL5170592)
Affinity DataKi:  0.170nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485947(CHEMBL2181008)
Affinity DataKi:  0.183nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485949(CHEMBL2180999)
Affinity DataKi:  0.198nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598737(CHEMBL5205631)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598741(CHEMBL5204894)
Affinity DataKi:  0.220nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399621(CHEMBL2181166)
Affinity DataKi:  0.230nMAssay Description:Displacement of radioligand from human 5HT4R by Cerep protocol based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598725(CHEMBL5185397)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598743(CHEMBL5178223)
Affinity DataKi:  0.260nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399622(CHEMBL2181168)
Affinity DataKi:  0.260nMAssay Description:Displacement of radioligand from human 5HT4R by Cerep protocol based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485948(CHEMBL2181007)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598745(CHEMBL5198823)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598734(CHEMBL5197480)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50485940(CHEMBL2181005)
Affinity DataKi:  0.367nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598736(CHEMBL5208095)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598744(CHEMBL5190323)
Affinity DataKi:  0.420nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598732(CHEMBL5192284)
Affinity DataKi:  0.700nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331549(CHEMBL567286 | [11C]-3-(2-oxo-3-(2-(4-(trifluorome...)
Affinity DataKi:  0.794nMAssay Description:Binding affinity to human dopamine D3 receptor by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Rattus norvegicus (Rat))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331549(CHEMBL567286 | [11C]-3-(2-oxo-3-(2-(4-(trifluorome...)
Affinity DataKi:  0.794nMAssay Description:Binding affinity to dopamine D3 receptor in rat native tissue by filtration binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50432574(CHEMBL2347169)
Affinity DataKi:  0.900nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells coexpressing macrophage scavenger receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414436(CHEMBL560574)
Affinity DataKi:  1nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50331549(CHEMBL567286 | [11C]-3-(2-oxo-3-(2-(4-(trifluorome...)
Affinity DataKi:  1nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598742(CHEMBL5182855)
Affinity DataKi:  1.10nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50399623(CHEMBL2181169)
Affinity DataKi:  1.20nMAssay Description:Displacement of radioligand from human 5HT4R by Cerep protocol based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414406(CHEMBL561512)
Affinity DataKi:  1.26nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414435(CHEMBL569846)
Affinity DataKi:  1.26nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50027366(Ketazocine | US10081602, Example Ketazocine | US10...)
Affinity DataKi:  1.30nM ΔG°:  -50.7kJ/mole IC50:  5.60nMpH: 7.5 T: 2°CAssay Description:Competition binding experiments were conducted by incubating membrane protein to equilibrium in triplicate in the presence of a fixed concentration o...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50027366(Ketazocine | US10081602, Example Ketazocine | US10...)
Affinity DataKi:  1.30nMpH: 7.5Assay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598729(CHEMBL5195600)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetKappa-type opioid receptor(Homo sapiens (Human))
Nektar Therapeutics

US Patent
LigandPNGBDBM50027366(Ketazocine | US10081602, Example Ketazocine | US10...)
Affinity DataKi:  1.30nMAssay Description:The binding affinities of certain compounds of the present invention were evaluated using radioligand binding assays in membranes prepared from CHO-K...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598727(CHEMBL5198338)
Affinity DataKi:  1.5nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414413(CHEMBL556272)
Affinity DataKi:  1.58nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414437(CHEMBL562624)
Affinity DataKi:  1.58nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50414409(CHEMBL565017)
Affinity DataKi:  1.58nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in CHO cells by [35S]GTP-gamma-S-based scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM50598735(CHEMBL5193267)
Affinity DataKi:  1.60nMAssay Description:Inhibition of human coagulation factor XIa assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTubulin beta chain(Sus scrofa)
University Of Bradford

Curated by ChEMBL
LigandPNGBDBM50014846((S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to pig brain tubulinMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50448473(CHEMBL3126399)
Affinity DataKi:  1.90nMAssay Description:Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Université

Curated by ChEMBL
LigandPNGBDBM50042235(2-butyl-3-{[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4...)
Affinity DataKi:  2nMAssay Description:In vitro binding affinity towards Angiotensin II receptor, type 1 of human hepatoma cell line PLC-PRF-5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
Universit£

Curated by ChEMBL
LigandPNGBDBM50399614(CHEMBL2181170)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]GR113808 from 5HT4R in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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