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Found 205 with Last Name = 'dudley' and Initial = 'dt'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50000558(CHEMBL437472 | ET-1 | Endothelin -1 | Endothelin 1...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of ET-1 binding to Endothelin B receptor in cultured rat cerebellar membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25077(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)
Affinity DataIC50:  1.92nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25073(4-[2-(4-bromophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Affinity DataIC50:  2.34nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25061(4-[(4-tert-butylphenyl)methyl]-6-{[(5Z)-4-oxo-2-su...)
Affinity DataIC50:  2.42nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25066(4-[(3,4-dimethylphenyl)methyl]-6-{[(5Z)-4-oxo-2-su...)
Affinity DataIC50:  2.59nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25068(4-[2-(3,5-dimethylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Affinity DataIC50:  2.65nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25080(4-[2-(3-methoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulf...)
Affinity DataIC50:  2.66nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25069(4-[2-(3,5-dimethoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-...)
Affinity DataIC50:  2.79nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25074(4-[2-(3-chlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Affinity DataIC50:  4.27nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25078(4-[2-(2,4-dichlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Affinity DataIC50:  4.28nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25075(4-[2-(3,4-dichlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Affinity DataIC50:  4.36nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25070(4-[2-(4-chlorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Affinity DataIC50:  4.76nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25081(4-[2-(3,4-difluorophenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Affinity DataIC50:  4.84nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25079(4-[2-(3-methylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Affinity DataIC50:  4.96nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25071(4-[2-(4-methoxyphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulf...)
Affinity DataIC50:  6.57nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25062(4-[(4-chlorophenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Affinity DataIC50:  7.16nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335377(CHEMBL1651534 | N-Pyridazin-3-yl-4-(3-{[5-(trifluo...)
Affinity DataIC50:  7.20nMAssay Description:Inhibition of His-tagged human FAAH N-terminal transmembrane-deleted truncated form expressed in Escherichia coli preincubated for 60 mins before ole...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50335377(CHEMBL1651534 | N-Pyridazin-3-yl-4-(3-{[5-(trifluo...)
Affinity DataIC50:  7.40nMAssay Description:Irreversible inhibition of His-tagged rat FAAH N-terminal transmembrane-deleted truncated form expressed in Escherichia coli preincubated for 60 mins...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25072(4-[2-(4-methylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-sulfa...)
Affinity DataIC50:  8.83nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032172((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  15nMAssay Description:Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM15234((1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-...)
Affinity DataIC50:  19nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
LigandPNGBDBM25059(4-benzyl-6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazo...)
Affinity DataIC50:  23nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25067(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)
Affinity DataIC50:  24.5nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B/1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045239(Ac-D-Dip-Leu-Asp-Ile-Ile-Trp | Ac-D-Dip-Leu-Asp-Il...)
Affinity DataIC50:  25nMAssay Description:Binding affinity against Endothelin receptor from rat heart ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25064(6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiazolidin-5-y...)
Affinity DataIC50:  27.5nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25060(4-[(4-methylphenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Affinity DataIC50:  29.5nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25076(4-[2-(4-tert-butylphenyl)ethyl]-6-{[(5Z)-4-oxo-2-s...)
Affinity DataIC50:  33.2nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045240((S)-2-[(S)-2-((2S,5S)-2-{(S)-2-[(S)-2-((R)-2-Acety...)
Affinity DataIC50:  36nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25063(4-[(3-oxo-6-{[(5Z)-4-oxo-2-sulfanylidene-1,3-thiaz...)
Affinity DataIC50:  36.1nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B/1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368647(CHEMBL1788127)
Affinity DataIC50:  40nMAssay Description:Binding affinity against Endothelin receptor from rat heart ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50008064((S)-3-Ethyl-4-(3-methyl-3H-imidazol-4-ylmethyl)-ox...)
Affinity DataIC50:  43nMAssay Description:Compound was evaluated for its ability to displace muscarinic agonist [3H]quinuclidinyl benzilate in rat cortical tissue (RCMD binding assay), at 0.1...More data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM25065(4-[(3-methylphenyl)methyl]-6-{[(5Z)-4-oxo-2-sulfan...)
Affinity DataIC50:  43.7nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244((S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  60nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244((S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  60nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50284007(CHEMBL412460 | Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Ser-Se...)
Affinity DataIC50:  60nMAssay Description:Binding affinity against Endothelin B receptor in rat cerebellar membrane (ET-B) from adult blue laurie ratMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368647(CHEMBL1788127)
Affinity DataIC50:  60nMAssay Description:Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045239(Ac-D-Dip-Leu-Asp-Ile-Ile-Trp | Ac-D-Dip-Leu-Asp-Il...)
Affinity DataIC50:  70nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50368647(CHEMBL1788127)
Affinity DataIC50:  70nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM25058((5Z)-5-[(3-hydroxy-5-methoxyphenyl)methylidene]-2-...)
Affinity DataIC50:  77.7nMpH: 7.4 T: 2°CAssay Description:PI3Kgamma activity was assessed by incubation of baculoviral co-expressed regulatory and catalytic subunits (p101 and p110) with lipid micelles prepa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B/1 receptor(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045230(Ac-D-Trp-Leu-Asp-Ile-Ile-Trp | CHEMBL313382)
Affinity DataIC50:  130nMAssay Description:Binding affinity against Endothelin receptor from rat heart ventricleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001220(3-{2-[2-Acetylamino-3-(1H-indol-3-yl)-propionylami...)
Affinity DataIC50:  130nMAssay Description:Inhibition of ET-1 binding to Endothelin A receptor in cultured rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001220(3-{2-[2-Acetylamino-3-(1H-indol-3-yl)-propionylami...)
Affinity DataIC50:  130nMAssay Description:Inhibition of ET-1 binding to Endothelin B receptor in cultured rat cerebellar membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045239(Ac-D-Dip-Leu-Asp-Ile-Ile-Trp | Ac-D-Dip-Leu-Asp-Il...)
Affinity DataIC50:  140nMAssay Description:Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50032172((S)-3-[(S)-2-((S)-2-Acetylamino-3,3-diphenyl-propi...)
Affinity DataIC50:  150nMAssay Description:Inhibition of ET-1 binding to Endothelin B receptor in cultured rat cerebellar membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045257(Ac-D-Phe-Leu-Asp-Ile-Ile-Tyr | CHEMBL89736)
Affinity DataIC50:  150nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244((S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  200nMAssay Description:Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50045244((S)-3-[(S)-2-((R)-2-Acetylamino-3-phenyl-propionyl...)
Affinity DataIC50:  200nMAssay Description:Binding affinity against ET A receptor from rabbit renal artery vascular smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50284006(CHEMBL438380 | Trp-Ile-Ile-Asp-Leu-Hisc(Cys-Ser-Ao...)
Affinity DataIC50:  240nMAssay Description:Binding affinity against Endothelin B receptor in rat cerebellar membrane (ET-B) from adult blue laurie ratMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEndothelin receptor type B(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50001219(3-{2-[2-Acetylamino-3-(4-hydroxy-phenyl)-propionyl...)
Affinity DataIC50:  250nMAssay Description:Effective concentration against Endothelin B receptor from rat cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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