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Found 73 with Last Name = 'dumont' and Initial = 'c'
TargetCytosolic purine 5'-nucleotidase(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50500514(CHEMBL3746819)
Affinity DataKi:  4.60E+5nMAssay Description:Non-competitive inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate h...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM68391((2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hy...)
Affinity DataKi:  5.00E+5nMAssay Description:Competitive type of inhibition of human 5'-nucleotidase using IMP as substrate assessed as inhibitor constant for free enzyme by Lineweaver-Burk plot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522285(CHEMBL4549109)
Affinity DataKi:  5.36E+5nMAssay Description:Mixed type inhibition of recombinant cN-II (unknown origin) assessed as inhibitor constant for free enzyme using varying level of IMP as substrate by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522285(CHEMBL4549109)
Affinity DataKi:  5.82E+5nMAssay Description:Competitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytosolic purine 5'-nucleotidase(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50500511(CHEMBL3746624)
Affinity DataKi:  7.90E+5nMAssay Description:Non-competitive inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate h...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522288(CHEMBL4518527)
Affinity DataKi:  8.43E+5nMAssay Description:Competitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50500515(CHEMBL3747390)
Affinity DataKi:  8.93E+5nMAssay Description:Competitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM68391((2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hy...)
Affinity DataKi:  9.00E+5nMAssay Description:Non-competitive type of inhibition of human 5'-nucleotidase using IMP as substrate assessed as inhibitor constant for enzyme substrate complex by Lin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic purine 5'-nucleotidase(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50500515(CHEMBL3747390)
Affinity DataKi:  9.50E+5nMAssay Description:Competitive inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate hydro...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50500515(CHEMBL3747390)
Affinity DataKi:  9.50E+5nMAssay Description:Competitive inhibition of 5'-nucleotidase (unknown origin) using varying level of IMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522288(CHEMBL4518527)
Affinity DataKi:  9.95E+5nMAssay Description:Mixed type inhibition of recombinant cN-II (unknown origin) assessed as inhibitor constant for free enzyme using varying level of IMP as substrate by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522286(CHEMBL3237671)
Affinity DataKi:  1.00E+6nMAssay Description:Competitive inhibition of 5'-nucleotidase (unknown origin) using varying level of IMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522285(CHEMBL4549109)
Affinity DataKi:  1.35E+6nMAssay Description:Uncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50500515(CHEMBL3747390)
Affinity DataKi:  1.48E+6nMAssay Description:Mixed type inhibition of recombinant cN-II (unknown origin) assessed as inhibitor constant for free enzyme using varying level of IMP as substrate by...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytosolic purine 5'-nucleotidase(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50500513(CHEMBL3746419)
Affinity DataKi:  1.65E+6nMAssay Description:Non-competitive inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate h...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522288(CHEMBL4518527)
Affinity DataKi:  1.65E+6nMAssay Description:Uncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522285(CHEMBL4549109)
Affinity DataKi:  2.00E+6nMAssay Description:Noncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50500510(CHEMBL3746211)
Affinity DataKi:  2.00E+6nMAssay Description:Competitive inhibition of 5'-nucleotidase (unknown origin) using varying level of IMP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic purine 5'-nucleotidase(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50500510(CHEMBL3746211)
Affinity DataKi:  2.00E+6nMAssay Description:Inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate hydrolysis by rap...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522287(CHEMBL4438573)
Affinity DataKi:  2.43E+6nMAssay Description:Competitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522287(CHEMBL4438573)
Affinity DataKi:  2.43E+6nMAssay Description:Mixed type inhibition of recombinant cN-II (unknown origin) assessed as inhibitor constant for free enzyme using varying level of IMP as substrate by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50500515(CHEMBL3747390)
Affinity DataKi:  2.44E+6nMAssay Description:Uncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522288(CHEMBL4518527)
Affinity DataKi:  2.52E+6nMAssay Description:Noncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytosolic purine 5'-nucleotidase(Homo sapiens)
Universit£

Curated by ChEMBL
LigandPNGBDBM50500512(CHEMBL3746515)
Affinity DataKi:  2.78E+6nMAssay Description:Competitive inhibition of recombinant N-terminal truncated human cytosolic 5'-nucleotidase-2 assessed as inhibition of inosine 5'-monophosphate hydro...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50500515(CHEMBL3747390)
Affinity DataKi:  3.36E+6nMAssay Description:Noncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot ana...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522287(CHEMBL4438573)
Affinity DataKi:  4.98E+6nMAssay Description:Uncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot anal...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50500515(CHEMBL3747390)
Affinity DataKi:  6.27E+6nMAssay Description:Mixed type inhibition of recombinant cN-II (unknown origin) assessed as inhibitor constant for enzyme substrate complex using varying level of IMP as...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522287(CHEMBL4438573)
Affinity DataKi:  6.97E+6nMAssay Description:Noncompetitive inhibition of recombinant cN-II (unknown origin) using varying level of IMP as substrate by HPLC method based Lineweaver-Burk plot ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50522288(CHEMBL4518527)
Affinity DataKi:  1.13E+7nMAssay Description:Mixed type inhibition of recombinant cN-II (unknown origin) assessed as inhibitor constant for enzyme substrate complex using varying level of IMP as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Inserm 1052/Cnrs 5286/University Of Lyon

Curated by ChEMBL
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PI3KCdelta/PIK3R1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Inserm 1052/Cnrs 5286/University Of Lyon

Curated by ChEMBL
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50:  12nMAssay Description:Inhibition of PI3KCgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Inserm 1052/Cnrs 5286/University Of Lyon

Curated by ChEMBL
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50:  17nMAssay Description:Inhibition of PI3KCdelta/PIK3R1 (unknown origin)More data for this Ligand-Target Pair
TargetD(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50224791(CHEMBL333795 | RU-29717)
Affinity DataIC50:  40nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in bovine anterior pituitary membrane using [3H]dihydroergocriptine as the radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Inserm 1052/Cnrs 5286/University Of Lyon

Curated by ChEMBL
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50:  49nMAssay Description:Inhibition of PI3KCbeta/PIK3R1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50028421(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50:  50nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in bovine anterior pituitary membrane using [3H]dihydroergocriptine as the radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50028421(9-Methylsulfanylmethyl-7-propyl-4,6,6a,7,8,9,10,10...)
Affinity DataIC50:  70nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in rat striatal membrane using [3H]spiroperidol as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224791(CHEMBL333795 | RU-29717)
Affinity DataIC50:  70nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in rat striatal membrane using [3H]spiroperidol as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50470564(CHEMBL4287314)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant CD73 (27 to 549 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells assessed as reduction in conv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Umr 5086 Cnrs

Curated by ChEMBL
LigandPNGBDBM50326928((2S,4R)-tert-butyl 4-(benzyloxy)-2-(((S)-6-(benzyl...)
Affinity DataIC50:  220nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH3T3 cells assessed as inhibition of drug efflux by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50470564(CHEMBL4287314)
Affinity DataIC50:  240nMAssay Description:Inhibition of CD73 in human NCI-H292 cells assessed as reduction in conversion of AMP to adenosine incubated for 30 mins by malachite green reagent b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224801(CHEMBL347326)
Affinity DataIC50:  250nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in rat striatal membrane using [3H]spiroperidol as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Inserm 1052/Cnrs 5286/University Of Lyon

Curated by ChEMBL
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50:  250nMAssay Description:Inhibition of PI3KCgamma (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50224798(CHEMBL148600)
Affinity DataIC50:  300nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in bovine anterior pituitary membrane using [3H]dihydroergocriptine as the radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Inserm 1052/Cnrs 5286/University Of Lyon

Curated by ChEMBL
LigandPNGBDBM50193013(Duvelisib | INK-1147 | INK-1197 | IPI-145)
Affinity DataIC50:  400nMAssay Description:Inhibition of PI3KCalpha/PIK3R1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(2) dopamine receptor(BOVINE)
TBA

Curated by ChEMBL
LigandPNGBDBM50224801(CHEMBL347326)
Affinity DataIC50:  500nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in bovine anterior pituitary membrane using [3H]dihydroergocriptine as the radioli...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224798(CHEMBL148600)
Affinity DataIC50:  600nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in rat striatal membrane using [3H]spiroperidol as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Inserm 1052/Cnrs 5286/University Of Lyon

Curated by ChEMBL
LigandPNGBDBM50403068(CHEMBL2216870 | IDELALISIB | US9745321, CAL-101)
Affinity DataIC50:  600nMAssay Description:Inhibition of PI3KCbeta/PIK3R1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Umr 5086 Cnrs

Curated by ChEMBL
LigandPNGBDBM50326930((2S,4R)-tert-butyl 4-(benzyloxy)-2-((S)-6-(benzylo...)
Affinity DataIC50:  730nMAssay Description:Inhibition of human MDR1 expressed in mouse NIH3T3 cells assessed as inhibition of drug efflux by flow cytometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224793(CHEMBL330997)
Affinity DataIC50:  800nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in rat striatal membrane using [3H]spiroperidol as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224799(CHEMBL147244)
Affinity DataIC50:  1.00E+3nMAssay Description:In vitro binding affinity towards dopamine receptor was determined in rat striatal membrane using [3H]spiroperidol as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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