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Found 1862 with Last Name = 'dyck' and Initial = 'b'
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188823(3-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-y...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168622((S)-3-{[5-(4-Ethyl-phenyl)-thiophene-2-carbonyl]-m...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168624((S)-3-{[5-(2-Chloro-4-methyl-phenyl)-thiophene-2-c...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50206687((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50171332(1-(2-Bromo-4-isopropyl-phenyl)-7-methyl-5-(1-propy...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189587((S)-6-(4-chlorophenyl)-2-(6-(3-(dimethylamino)pyrr...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189584((R)-6-(4-chlorophenyl)-2-(6-(3-(dimethylamino)pyrr...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189581((S)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189592((R)-2-(4-methoxyphenyl)-6-(6-(3-(methylamino)pyrro...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188825((S)-7-(4-chlorophenyl)-3-(6-(3-(dimethylamino)pyrr...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189589((R)-6-(4-chlorophenyl)-2-(6-(3-(methylamino)pyrrol...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188826((R)-7-(4-chlorophenyl)-3-(6-(3-(dimethylamino)pyrr...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189582((S)-6-(4-chlorophenyl)-2-(6-(3-(pyrrolidin-1-ylami...)
Affinity DataKi:  1.60nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50160730(3-{(S)-Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189579((S)-6-(4-chlorophenyl)-2-(6-(3-(ethylamino)pyrroli...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189578((R)-2-(4-chlorophenyl)-6-(6-(3-(methylamino)pyrrol...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189593((S)-2-(4-fluorophenyl)-6-(6-(3-(methylamino)pyrrol...)
Affinity DataKi:  2nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168616((S)-3-{[5-(2-Chloro-4-ethoxy-phenyl)-thiophene-2-c...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188817(3-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-y...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50171318(1-(4-Methoxy-phenyl)-7-methyl-5-(1-propyl-butyl)-4...)
Affinity DataKi:  2nMAssay Description:Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50206675((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168611((S)-3-{Methyl-[5-(4-trifluoromethyl-phenyl)-thioph...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168615((S)-3-[(4'-Chloro-biphenyl-4-carbonyl)-methyl-amin...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168618((S)-3-{[5-(4-Chloro-phenyl)-thiophene-2-carbonyl]-...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188834(7-(4-chlorophenyl)-3-(6-(3-(dimethylamino)pyrrolid...)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189594((R)-2-(4-fluorophenyl)-6-(6-(3-(methylamino)pyrrol...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189591((R)-2-(4-ethylphenyl)-6-(6-(3-(methylamino)pyrroli...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168462(2-(2,4-Dichloro-phenyl)-4-methyl-6-(1-propyl-butyl...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168623((S)-3-{[5-(2,4-Dichloro-phenyl)-thiophene-2-carbon...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168633((S)-3-[Methyl-(5-p-tolyl-thiophene-2-carbonyl)-ami...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168630((S)-3-{[5-(2,4-Dimethyl-phenyl)-thiophene-2-carbon...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168635((S)-3-{[5-(4-Methoxy-2-methyl-phenyl)-thiophene-2-...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168605((S)-3-{[5-(4-Chloro-2-methyl-phenyl)-thiophene-2-c...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50206679((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50206666((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188835(7-(4-bromophenyl)-3-(6-(3-(dimethylamino)pyrrolidi...)
Affinity DataKi:  3nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50074501(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity for corticotropin-releasing factor-1 expressed in leukocyte tyrosine kinase cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50074501(Butyl-ethyl-[2,5,6-trimethyl-7-(2,4,6-trimethyl-ph...)
Affinity DataKi:  3.10nMAssay Description:Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189586((S)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188832(3-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-y...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(RAT)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50189576((R)-6-(6-(3-(methylamino)pyrrolidin-1-yl)pyridin-3...)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to chimeric rat/human MCH1R stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168475(1-(2-Chloro-4-methyl-phenyl)-7-methyl-5-(1-propyl-...)
Affinity DataKi:  3.5nMAssay Description:Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168631((S)-3-{Methyl-[5-(4-trifluoromethoxy-phenyl)-thiop...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168628((S)-3-{[5-(4-Methoxy-phenyl)-thiophene-2-carbonyl]...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards the human MCH-R1 receptor by displacing [125I]-Tyr13]-MCH radioligand in HEK293 cells, Data is average of 3 or more independ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50206681((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50206690((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50206677((S)-3-(6-(4-chlorophenyl)-4-oxothieno[3,2-d]pyrimi...)
Affinity DataKi:  4nMAssay Description:Binding affinity to human MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50190268(4'-methylsulfanyl-biphenyl-4-carboxylic acid methy...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I-Tyr13]MCH from human MCHR1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50188820(3-(6-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-3-y...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity to human MCH1RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50168466(1-(2,4-Dichloro-phenyl)-7-methyl-5-(1-propyl-butyl...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of [125I]sauvagine binding to corticotropin releasing factor receptor 1 expressed in LtK- cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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