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Found 2167 with Last Name = 'edwards' and Initial = 'l'
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073585(CHEMBL3408945 | US10358436, Example A102 | US99078...)
Affinity DataKi:  0.100nMAssay Description:Competitive binding to PLK4 (unknown origin) by double reciprocal plot analysis in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50090516(5-tert-Butyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl...)
Affinity DataKi:  0.25nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataKi:  0.260nMAssay Description:Competitive binding to PLK4 (unknown origin) by double reciprocal plot analysis in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50090517(5-Isopropyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)...)
Affinity DataKi:  0.290nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133454(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133462(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133466(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.380nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50090519(CHEMBL300519 | [2-(5-Isopropyl-1H-indol-3-yl)-ethy...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133457(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.420nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133465(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133468(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50090523(2-(5-tert-Butyl-1-methyl-1H-indol-3-yl)-ethylamine...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133453(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133451(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.560nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133458(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.680nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM50081537(CHEMBL3422092)
Affinity DataKi:  0.700nMAssay Description:Competitive inhibition of amino terminal GST-fused full length human TTK using His6-SUMO-TTK-N as substrate by Lineweaver-Burk plot analysis in prese...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133459(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50073586(CHEMBL3408946 | US10358436, Example A198 | US99078...)
Affinity DataKi:  0.730nMAssay Description:Competitive binding to PLK4 (unknown origin) by double reciprocal plot analysis in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133452(5-[1-(4-Methoxy-benzenesulfonyl)-1,2,3,6-tetrahydr...)
Affinity DataKi:  0.760nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133464(3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-5-[1-(tolue...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133455(3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-5-[1-(napht...)
Affinity DataKi:  0.880nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50060429((R)-2-(4-Fluoro-phenyl)-2-{1-[3-(5-[1,2,4]triazol-...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50090522(5-Ethyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H-...)
Affinity DataKi:  0.970nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50110941(1-(2,4-Dichloro-phenyl)-4-methyl-5-(4-pentyl-pheny...)
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]-CP-55,940 binding to cannabinoid receptor 1 in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of [3H]-CP-55,940 binding to cannabinoid receptor 1 in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50136466(CHEMBL343492 | Dimethyl-[2-(6-pyridin-3-yl-indol-1...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133462(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133451(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133467(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50136469(4-[1-(2-Dimethylamino-ethyl)-1H-indol-6-yl]-tetrah...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133453(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50090521(5-tert-Butyl-3-(2-pyrrolidin-1-yl-ethyl)-1H-indole...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133454(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50110940(5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-meth...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-CP-55,940 binding to cannabinoid receptor 1 in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133456(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
University Of South Carolina

Curated by ChEMBL
LigandPNGBDBM50110942(5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-meth...)
Affinity DataKi:  3nMAssay Description:Inhibition of [3H]-CP-55,940 binding to cannabinoid receptor 1 in rat brain membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133459(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  3.20nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50136462(4-[1-(2-Dimethylamino-ethyl)-1H-indol-6-yl]-tetrah...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity of the compound was evaluated at the cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.40nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50090515(5-Methyl-3-((R)-1-methyl-pyrrolidin-2-ylmethyl)-1H...)
Affinity DataKi:  3.5nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50136465(CHEMBL343105 | Dimethyl-{2-[6-(tetrahydro-pyran-4-...)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133466(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133468(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50133463(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  4nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1D receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of PLK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Nps Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133457(4-[3-((R)-1-Methyl-pyrrolidin-2-ylmethyl)-1H-indol...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Nps Allelix

Curated by ChEMBL
LigandPNGBDBM50136471((S)-1-{2-[4-(4-Carbamoyl-phenyl)-piperazin-1-yl]-e...)
Affinity DataKi:  4.60nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1D receptor expressed in Chinese hamster ovary cells (CHO cells)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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