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Found 525 with Last Name = 'egan' and Initial = 'da'
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022633(CHEMBL3142281 | [1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.200nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022635(CHEMBL3142255 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.25nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014078(A-62198 | CHEMBL291591 | N-{(S)-1-[(S)-1-((1S,2R,3...)
Affinity DataIC50:  0.290nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022597(CHEMBL3142268 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022619(CHEMBL3348544 | N-[1-(1-Cyclohexylmethyl-2,3-dihyd...)
Affinity DataIC50:  0.300nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014084((R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmeth...)
Affinity DataIC50:  0.330nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014084((R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmeth...)
Affinity DataIC50:  0.370nMpH: 6.5Assay Description:Inhibitory activity against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017780(CHEMBL284451 | {1-[1-(4-Azido-1-cyclohexylmethyl-2...)
Affinity DataIC50:  0.400nMpH: 6.0Assay Description:Inhibitory activity against purified human renal renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017780(CHEMBL284451 | {1-[1-(4-Azido-1-cyclohexylmethyl-2...)
Affinity DataIC50:  0.400nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014081((R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmeth...)
Affinity DataIC50:  0.490nMpH: 6.5Assay Description:Inhibitory activity against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022603(CHEMBL3348551 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022599(CHEMBL3142262 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022628(CHEMBL3142261 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.5nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017783(CHEMBL440779 | N-{1-[1-(4-Azido-1-cyclohexylmethyl...)
Affinity DataIC50:  0.550nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017783(CHEMBL440779 | N-{1-[1-(4-Azido-1-cyclohexylmethyl...)
Affinity DataIC50:  0.550nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014084((R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmeth...)
Affinity DataIC50:  0.570nMpH: 7.4Assay Description:Inhibitory activity against human plasma renin at pH 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014073((R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmeth...)
Affinity DataIC50:  0.590nMpH: 6.5Assay Description:Inhibitory activity against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022595(CHEMBL3348552 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50011231(2-Benzyl-N-{1-[1-cyclohexylmethyl-2-(3-ethyl-2-oxo...)
Affinity DataIC50:  0.600nMpH: 6.5Assay Description:Compound was evaluated for the inhibitory concentration against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022598(CHEMBL3348548 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  0.600nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50017782(CHEMBL280744 | Tetrahydro-pyran-4-carboxylic acid ...)
Affinity DataIC50:  0.700nMpH: 6.0Assay Description:Inhibitory activity against purified human plasma renin at pH 6.0More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022630(CHEMBL3348531 | Cyclohexanecarboxylic acid {1-[1-(...)
Affinity DataIC50:  0.700nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022637(2-(2-Acetylamino-3-phenyl-propionylamino)-N-(1-cyc...)
Affinity DataIC50:  0.75nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014079((R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmeth...)
Affinity DataIC50:  0.850nMpH: 6.5Assay Description:Inhibitory activity against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006157(5-{2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)...)
Affinity DataIC50:  0.900nMpH: 6.0Assay Description:In vitro potency against plasma renin at a pH of 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006189((4-{2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl...)
Affinity DataIC50:  0.900nMpH: 6.0Assay Description:In vitro activity against human renin (pH 6.0)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006147(2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-...)
Affinity DataIC50:  0.900nMpH: 7.4Assay Description:In vitro potency against purified renin at a pH of 6.0.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50011228((R)-2-Benzyl-N-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-...)
Affinity DataIC50:  0.990nMpH: 6.5Assay Description:Compound was evaluated for the inhibitory concentration against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50011228((R)-2-Benzyl-N-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-...)
Affinity DataIC50:  0.990nMpH: 6.5Assay Description:Inhibitory activity against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006206(5-{2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)...)
Affinity DataIC50:  1nMpH: 6.0Assay Description:In vitro activity against human renin (pH 6.0)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006152(2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-...)
Affinity DataIC50:  1nMpH: 6.0Assay Description:In vitro potency against plasma renin at a pH of 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006185(5-{2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)...)
Affinity DataIC50:  1nMpH: 6.0Assay Description:In vitro potency against human plasma renin at a pH of 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022638(CHEMBL3348542 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022615(CHEMBL3348546 | N-{1-[1-(1-Cyclohexylmethyl-2,3-di...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006152(2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-...)
Affinity DataIC50:  1nMpH: 6.0Assay Description:In vitro potency against human plasma renin at a pH of 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022620(CHEMBL3348532 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022607(CHEMBL3348540 | [1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506946(CHEMBL4472858)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human recombinant ROCK2 (11 to 552 residues) expressed in Spodoptera frugiperda insect cells using STK S2 peptide substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK1 (unknown origin) incubated for 2 hrs by AbbVie kinase panel assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506950(CHEMBL4434688)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-fused human recombinant ROCK2 (11 to 552 residues) expressed in Spodoptera frugiperda insect cells using STK S2 peptide substrate a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50:  1nMAssay Description:Inhibition of ROCK2 (unknown origin) incubated for 2 hrs by AbbVie kinase panel assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
Abbvie Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50506948(CHEMBL4448806)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKG1A (unknown origin) incubated for 2 hrs by AbbVie kinase panel assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022593(CHEMBL3142304 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50406090(CHEMBL2112610)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against human renal renin using radioimmuno assay for angiotensin I productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022611(CHEMBL3142260 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006161(2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-...)
Affinity DataIC50:  1.10nMpH: 6.0Assay Description:In vitro activity against human renin (pH 6.0)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50022636(CHEMBL3142269 | {1-[1-(1-Cyclohexylmethyl-2,3-dihy...)
Affinity DataIC50:  1.10nMAssay Description:In vitro inhibitory activity was tested against purified human renal reninMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50014081((R)-2-Benzyl-N*1*-[(S)-1-[(1S,2R)-1-cyclohexylmeth...)
Affinity DataIC50:  1.10nMpH: 7.4Assay Description:Inhibitory activity against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50011229(2-Benzyl-N-[1-[1-cyclohexylmethyl-2-(3-ethyl-2-oxo...)
Affinity DataIC50:  1.10nMpH: 6.5Assay Description:Compound was evaluated for the inhibitory concentration against purified human renal renin at pH 6.5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50006161(2-[1-Benzyl-2-(4-methoxymethoxy-piperidin-1-yl)-2-...)
Affinity DataIC50:  1.10nMpH: 6.0Assay Description:In vitro potency against purified renin at a pH of 7.4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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