Compile Data Set for Download or QSAR
maximum 50k data
Found 45 with Last Name = 'gee' and Initial = 'cl'
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  1.55nMAssay Description:Binding affinity to human wild type his-tagged PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13014(7,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline; hydr...)
Affinity DataKi:  3.10nM ΔG°:  -50.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50077537((+)-(7-nitro-1,2,3,4-tetrahydroisoquinolin-3-yl)me...)
Affinity DataKi:  17nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13027(3-(hydroxymethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4...)
Affinity DataKi:  23nM ΔG°:  -45.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13028(3-(fluoromethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4...)
Affinity DataKi:  35nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13025(7-sulfonamide-THIQ 15 | CHEMBL176112 | N-(4-chloro...)
Affinity DataKi:  39nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM14060(7-Iodo-1,2,3,4-tetrahydroisoquinoline | CHEMBL2682...)
Affinity DataKi:  40nMAssay Description:Binding affinity to human wild type his-tagged PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13024(7-sulfonamide-THIQ 14 | CHEMBL290890 | N-(4-chloro...)
Affinity DataKi:  46nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13023(3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7...)
Affinity DataKi:  52nM ΔG°:  -43.2kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13025(7-sulfonamide-THIQ 15 | CHEMBL176112 | N-(4-chloro...)
Affinity DataKi:  63nM ΔG°:  -42.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human wild type his-tagged PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13026(3-(fluoromethyl)-N-(2,2,2-trifluoroethyl)-1,2,3,4-...)
Affinity DataKi:  130nM ΔG°:  -40.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13022(3-(fluoromethyl)-1,2,3,4-tetrahydroisoquinoline-7-...)
Affinity DataKi:  150nM ΔG°:  -40.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50061310(1,2,3,4-Tetrahydro-isoquinoline-7-sulfonic acid (4...)
Affinity DataKi:  210nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13028(3-(fluoromethyl)-N-(3,3,3-trifluoropropyl)-1,2,3,4...)
Affinity DataKi:  220nM ΔG°:  -39.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13024(7-sulfonamide-THIQ 14 | CHEMBL290890 | N-(4-chloro...)
Affinity DataKi:  270nM ΔG°:  -39.0kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  280nM ΔG°:  -38.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50151343((+)-3-(fluoromethyl)-7-(thiomorpholinosulfonyl)-1,...)
Affinity DataKi:  315nMAssay Description:Inhibition of wild type human PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13018(7-methanesulfonyl-1,2,3,4-tetrahydroisoquinoline |...)
Affinity DataKi:  790nM ΔG°:  -36.2kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13041(3-(fluoromethyl)-7-methanesulfonyl-1,2,3,4-tetrahy...)
Affinity DataKi:  1.10E+3nM ΔG°:  -35.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13034(((+/-)-3-Fluoromethyl-7-(3,3,3-trifluoropropylsulf...)
Affinity DataKi:  1.30E+3nM ΔG°:  -34.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50100952(1-(2,3-Dichloro-phenyl)-ethylamine | 2,3-dichloro-...)
Affinity DataKi:  1.33E+3nMAssay Description:Binding affinity to human free PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13030(7-sulfonamide-THIQ 20 | CHEMBL177861 | N-ethyl-3-(...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13040(3-(fluoromethyl)-7-[(2,2,2-trifluoroethane)sulfony...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13031(3-(fluoromethyl)-N-propyl-1,2,3,4-tetrahydroisoqui...)
Affinity DataKi:  1.70E+3nM ΔG°:  -34.3kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50072991(7-Nitro-1,2,3,4-tetrahydro-isoquinoline | 7-nitro-...)
Affinity DataKi:  2.36E+3nMAssay Description:Binding affinity to human free PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13037(3-(fluoromethyl)-7-(propane-1-sulfonyl)-1,2,3,4-te...)
Affinity DataKi:  2.40E+3nM ΔG°:  -33.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13017(1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | CHE...)
Affinity DataKi:  2.84E+3nMAssay Description:Binding affinity to human free PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13029(3-(fluoromethyl)-N-methyl-1,2,3,4-tetrahydroisoqui...)
Affinity DataKi:  3.70E+3nM ΔG°:  -32.3kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM14061(8,9-Dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine |...)
Affinity DataKi:  4.40E+3nMAssay Description:Binding affinity to human wild type his-tagged PNMTMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13032(3-(fluoromethyl)-N-(2-methoxyethyl)-1,2,3,4-tetrah...)
Affinity DataKi:  5.10E+3nM ΔG°:  -31.4kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13016(1,2,3,4-tetrahydroisoquinoline | CHEMBL14346 | THI...)
Affinity DataKi:  5.80E+3nM ΔG°:  -31.1kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13021(7-(trichloromethane)sulfonyl-1,2,3,4-tetrahydroiso...)
Affinity DataKi:  6.30E+3nM ΔG°:  -30.9kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13020(7-(prop-2-ene-1-sulfonyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataKi:  9.00E+3nM ΔG°:  -30.0kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13036(((+/-)-7-Ethylsulfonyl-3-fluoromethyl-1,2,3,4-tetr...)
Affinity DataKi:  1.40E+4nM ΔG°:  -28.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50176890(2-(3,4-Dichloro-phenyl)-1-methyl-ethylamine | 3,4-...)
Affinity DataKi:  1.48E+4nMAssay Description:Binding affinity to human free PNMTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13038(7-(butane-1-sulfonyl)-3-(fluoromethyl)-1,2,3,4-tet...)
Affinity DataKi:  1.80E+4nM ΔG°:  -28.2kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13019(7-(benzenesulfonyl)-1,2,3,4-tetrahydroisoquinoline...)
Affinity DataKi:  2.30E+4nM ΔG°:  -27.5kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13033(((+/-)-3-Fluoromethyl-7-(4-chlorobenzylsulfonyl)-1...)
Affinity DataKi:  3.20E+4nM ΔG°:  -26.7kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13035(((+/-)-3-Fluoromethyl-7-(4,4,4-trifluorobutylsulfo...)
Affinity DataKi:  6.70E+4nM ΔG°:  -24.8kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM13039(3-(fluoromethyl)-7-[(3-methoxypropane)sulfonyl]-1,...)
Affinity DataKi:  7.20E+4nM ΔG°:  -24.6kJ/molepH: 8.0 T: 2°CAssay Description:Enzyme activity is determined by measuring the amount of 3H incorporated into the substrate during the reaction. AdoMet/[methyl-3H]AdoMet serves as a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50176887(CHEMBL224526 | phenylethanolamine)
Affinity DataKd:  1.80E+5nMAssay Description:Activity of human wild type PNMT assessed as phenylethanolamine methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50176889(6-Trifluoromethyl-1,2,3,4-tetrahydro-1,4-methano-n...)
Affinity DataKd:  4.40E+3nMAssay Description:Activity of human wild type PNMT assessed as phenylethanolamine methylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM28422((2S)-2-amino-4-({[(2S,3S,4R,5R)-5-(6-amino-9H-puri...)
Affinity DataKd:  4.80E+3nMAssay Description:Activity of human wild type PNMT assessed as phenylethanolamine methylationMore data for this Ligand-Target Pair
TargetPhenylethanolamine N-methyltransferase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM50176888(3-trifluoromethylphenylethanolamine | CHEMBL224618)
Affinity DataKd:  2.40E+3nMAssay Description:Activity of human wild type PNMT assessed as phenylethanolamine methylationMore data for this Ligand-Target Pair