BindingDB PrimarySearch_ki

Found 503 with Last Name = 'hixon' and Initial = 'ms'

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Ki: 0.0210nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50327046(1-(2-fluoro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)

Ki: 0.0240nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by activity based 100 fold dilution assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50327046(1-(2-fluoro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)

Ki: 0.0440nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by ligand displacement based enzyme-inhibitor dilution assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Ki: 0.120nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 60 mins by ligand displacement based enzyme-inhibitor dilution assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Catechol O-methyltransferase(Homo sapiens (Human))
Takeda California

Curated by ChEMBL

PNG

BDBM50019329(CHEMBL1089318)

Ki: 1nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB Similars

Details Article PubMed

Catechol O-methyltransferase(Rattus norvegicus (Rat))
Takeda California

Curated by ChEMBL

PNG

BDBM50019329(CHEMBL1089318)

Ki: 1.5nMAssay Description:Inhibition of catalytic activity of rat COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid scint...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Catechol O-methyltransferase(Mus musculus)
Takeda California

Curated by ChEMBL

PNG

BDBM50019329(CHEMBL1089318)

Ki: 1.5nMAssay Description:Inhibition of catalytic activity of mouse COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liquid sci...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)

Ki: 1.70nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 10 mins by Global fit analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL KEGG PC cid PC sid Patents Similars

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM4814(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)

Ki: 2.90nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 10 mins by Global fit analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50327046(1-(2-fluoro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)

Ki: 4.60nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 10 mins by Global fit analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)

Ki: 22nMAssay Description:Inhibition of human N-terminal His-tagged non-phosphorylated VEGFR2 after 10 mins by Global fit analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase ChEBI
CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed DrugBank
PDB

3D Structure (crystal)

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50327046(1-(2-fluoro-4-(5-methyl-5H-pyrrolo[3,2-d]pyrimidin...)

Ki: 23nMAssay Description:Inhibition of human N-terminal His-tagged phosphorylated VEGFR2 in presence of ATP measured without preincubation by AlphaScreen analysisMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Patents Similars

Details Article PubMed PDB

3D Structure (crystal)

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM23274((2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamid...)

Ki: 300nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

DrugBank MMDB PC cid PC sid PDB Similars

Details Article PubMed MMDB
PDB

3D Structure (crystal)

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM23274((2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamid...)

Ki: 300nMAssay Description:Competitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

DrugBank MMDB PC cid PC sid PDB Similars

Details Article PubMed MMDB
PDB

3D Structure (crystal)

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50048521(CHEMBL3309329)

Ki: 460nMAssay Description:Competitive inhibition of Clostridium botulinum neurotoxin serotype A light chainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50076267((2S,3S)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acry...)

Ki: 1.40E+3nMAssay Description:Competitive inhibition of Clostridium botulinum full length BoNT/A light chain (1-448) using truncated SNAP 25 (141-206) peptide as substrate by LC/M...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50076267((2S,3S)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acry...)

Ki: 1.60E+3nMAssay Description:Uncompetitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/M...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Carboxylic ester hydrolase(Equus caballus (Horse))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359284(CHEMBL1928379)

Ki: 1.60E+3nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as a substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50582282(CHEMBL5077928)

Ki: 2.47E+3nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50582281(CHEMBL5084806)

Ki: 2.84E+3nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Acetylcholinesterase(Electrophorus electricus (Electric eel))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359293(CHEMBL1928397)

Ki: 3.20E+3nMAssay Description:Inhibition of Electrophorus electricus Type V-S acetylcholinesterase using acetylcholine iodide as substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid

Details Article PubMed

Acetylcholinesterase(Electrophorus electricus (Electric eel))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359287(CHEMBL1928382)

Ki: 3.90E+3nMAssay Description:Inhibition of Electrophorus electricus Type V-S acetylcholinesterase using acetylcholine iodide as substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50076267((2S,3S)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acry...)

Ki: 3.90E+3nMAssay Description:Uncompetitive inhibition of Clostridium botulinum full length BoNT/A light chain (1-448) using truncated SNAP 25 (141-206) peptide as substrate by LC...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50582280(CHEMBL5093260)

Ki: 4.66E+3nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Bcl-2-like protein 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50036201(CHEMBL3358688)

Ki: 4.70E+3nMAssay Description:Displacement of F-bid from human recombinant N-terminal His-tagged Bcl-xL (1 to 209) expressed in Escherichia coli BL21(DE3) after 2 hrs by fluoresce...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM23274((2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamid...)

Ki: 5.60E+3nMAssay Description:Competitive inhibition of Clostridium botulinum full length BoNT/A light chain (1-448) using truncated SNAP 25 (141-206) peptide as substrate by LC/M...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

DrugBank MMDB PC cid PC sid PDB Similars

Details Article PubMed MMDB
PDB

3D Structure (crystal)

Acetylcholinesterase(Electrophorus electricus (Electric eel))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359285(CHEMBL1928380)

Ki: 5.70E+3nMAssay Description:Inhibition of Electrophorus electricus Type V-S acetylcholinesterase using acetylcholine iodide as substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Catechol O-methyltransferase(Homo sapiens (Human))
Takeda California

Curated by ChEMBL

PNG

BDBM50019331(CHEMBL3289430)

Ki: 6.30E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50582279(CHEMBL5082512)

Ki: 6.31E+3nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM43865(6-formyl-4,7-dihydroxy-9-keto-5H-phenazine-1-carbo...)

Ki: 6.70E+3nMAssay Description:Competitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50076267((2S,3S)-2,3-Bis-[(E)-3-(3,4-dihydroxy-phenyl)-acry...)

Ki: 6.70E+3nMAssay Description:Competitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/MS ...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM43865(6-formyl-4,7-dihydroxy-9-keto-5H-phenazine-1-carbo...)

Ki: 6.70E+3nMAssay Description:Non-competitive inhibition of Clostridium botulinum neurotoxin serotype A light chain using 66-mer peptide by LC/MS assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM43865(6-formyl-4,7-dihydroxy-9-keto-5H-phenazine-1-carbo...)

Ki: 6.70E+3nMAssay Description:Uncompetitive inhibition of Clostridium botulinum truncated BoNT/A light chain (1-425) using truncated SNAP 25 (141-206) peptide as substrate by LC/M...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

PC cid PC sid Similars

Details Article PubMed

Acetylcholinesterase(Electrophorus electricus (Electric eel))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359289(CHEMBL1928384)

Ki: 6.80E+3nMAssay Description:Inhibition of Electrophorus electricus Type V-S acetylcholinesterase using acetylcholine iodide as substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50048539(CHEMBL3309328)

Ki: 7.70E+3nMAssay Description:Inhibition of Clostridium botulinum neurotoxin serotype A light chainMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase CHEMBL PC cid PC sid

Details Article PubMed

Catechol O-methyltransferase(Homo sapiens (Human))
Takeda California

Curated by ChEMBL

PNG

BDBM50019333(CHEMBL3289432)

Ki: 7.90E+3nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Patents Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50582278(CHEMBL5076439)

Ki: >8.00E+3nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Bcl-2-like protein 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50036202(CHEMBL3358689)

Ki: 9.00E+3nMAssay Description:Reversible inhibition of human recombinant N-terminal His-tagged Bcl-xL (1 to 209) expressed in Escherichia coli BL21(DE3) after 30 to 120 mins by TR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Acetylcholinesterase(Electrophorus electricus (Electric eel))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359284(CHEMBL1928379)

Ki: 1.09E+4nMAssay Description:Inhibition of Electrophorus electricus Type V-S acetylcholinesterase using acetylcholine iodide as substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Induced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50036201(CHEMBL3358688)

Ki: 1.20E+4nMAssay Description:Displacement of F-bid from human recombinant N-terminal His-tagged Mcl-1 (1 to 319) expressed in Escherichia coli BL21(DE3) after 120 mins by TR-FRET...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Details Article PubMed

Bcl-2-like protein 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50036201(CHEMBL3358688)

Ki: 1.20E+4nMAssay Description:Displacement of F-bid from human recombinant N-terminal His-tagged Bcl-xL (1 to 209) expressed in Escherichia coli BL21(DE3) after 120 mins by TR-FRE...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Details Article PubMed

Acetylcholinesterase(Electrophorus electricus (Electric eel))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359286(CHEMBL1928381)

Ki: 1.21E+4nMAssay Description:Inhibition of Electrophorus electricus Type V-S acetylcholinesterase using acetylcholine iodide as substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

UniProtKB/SwissProt
GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Bcl-2-like protein 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50036201(CHEMBL3358688)

Ki: 1.30E+4nMAssay Description:Reversible inhibition of human recombinant N-terminal His-tagged Bcl-xL (1 to 209) expressed in Escherichia coli BL21(DE3) after 30 to 120 mins by TR...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Details Article PubMed

Induced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50036201(CHEMBL3358688)

Ki: 1.40E+4nMAssay Description:Displacement of F-bid from human recombinant N-terminal His-tagged Mcl-1 (1 to 319) expressed in Escherichia coli BL21(DE3) after 2 hrs by fluorescen...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Details Article PubMed

Carboxylic ester hydrolase(Equus caballus (Horse))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359286(CHEMBL1928381)

Ki: 1.44E+4nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as a substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50582277(CHEMBL5082531)

Ki: >1.60E+4nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Botulinum neurotoxin type A(Clostridium botulinum)
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50582283(CHEMBL4776429)

Ki: 1.72E+4nMAssay Description:Inhibition of Clostridium botulinum BoNT/A light chain assessed as inhibition constant at 10 nM using SNAPtide flp6 as substrate measured after 30 mi...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD GoogleScholar

Details Article PubMed

Induced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL

PNG

BDBM50036202(CHEMBL3358689)

Ki: 2.00E+4nMAssay Description:Displacement of F-bid from human recombinant N-terminal His-tagged Mcl-1 (1 to 319) expressed in Escherichia coli BL21(DE3) after 120 mins by TR-FRET...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Catechol O-methyltransferase(Homo sapiens (Human))
Takeda California

Curated by ChEMBL

PNG

BDBM50019332(CHEMBL3289431)

Ki: 2.50E+4nMAssay Description:Inhibition of catalytic activity of human cloned COMT expressed in Escherichia coli using [3H]-S-adenosylmethionine as substrate after 20 mins by liq...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid Similars

Details Article PubMed

Carboxylic ester hydrolase(Equus caballus (Horse))
The Scripps Research Institute

Curated by ChEMBL

PNG

BDBM50359285(CHEMBL1928380)

Ki: 2.50E+4nMAssay Description:Inhibition of equine serum BChE using butyrylthiocholine iodide as a substrate by spectrophotometric Ellman's assayMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/TrEMBL
B.MOAD GoogleScholar

CHEMBL PC cid PC sid Similars

Details Article PubMed

Displayed 1 to 50 (of 503 total ) | Next | Last >>

Filter my 503 hits

Targets 21▿
- TGF-beta receptor type-1 169
- Botulinum neurotoxin type A 51
- Cytochrome P450 3A4 42
- Cytochrome P450 1A2 36
- Vascular endothelial growth factor receptor 2 33
- Carboxylic ester hydrolase 30
- Acetylcholinesterase 29
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 28
- Myc proto-oncogene protein 20
- Catechol O-methyltransferase 13
- Cytochrome P450 2C8 13
- Dual specificity mitogen-activated protein kinase kinase 3 7
- Botulinum neurotoxin type A2 [1-425] 7
- Acyl-CoA (8-3)-desaturase 7
- Bcl-2-like protein 1 6
- Induced myeloid leukemia cell differentiation protein Mcl-1 3
- Mitogen-activated protein kinase kinase kinase 2 2
- Acyl-CoA desaturase 1 2
- Mitogen-activated protein kinase 14 2
- Acyl-CoA 6-desaturase 2
- Dual specificity mitogen-activated protein kinase kinase 6 1
- ...
Publications 17▿
- Bioorg Med Chem Lett 26: 4334-9 (2016) 152
- Bioorg Med Chem Lett 27: 1955-1961 (2017) 110
- Bioorg Med Chem 19: 6203-9 (2011) 59
- J Med Chem 60: 5209-5215 (2017) 28
- Bioorg Med Chem 19: 5342-51 (2011) 26
- Bioorg Med Chem 22: 3971-81 (2014) 22
- Bioorg Med Chem 26: 4234-4239 (2018) 20
- J Med Chem 57: 5459-63 (2014) 13
- ACS Med Chem Lett 7: 868-72 (2016) 11
- ACS Med Chem Lett 13: 742-747 (2022) 11
- Bioorg Med Chem Lett 26: 1086-9 (2016) 10
- ACS Med Chem Lett 4: 283-287 (2013) 9
- Bioorg Med Chem Lett 24: 5836-9 (2014) 9
- Proc Natl Acad Sci U S A 104: 2602-7 (2007) 7
- ACS Med Chem Lett 3: 342-346 (2012) 7
- Bioorg Med Chem Lett 20: 206-8 (2010) 7
- ACS Med Chem Lett 1: 268-272 (2010) 2
Institutions 4▿
- Takeda California 313
- The Scripps Research Institute 135
- Takeda Pharmaceutical 46
- TBA 9
Affinity: 0.021 to 1.3E+6 nM▿
- Ki 70
- IC50 335
- Kd 11
- EC50 87
- Affinity ≤ nM
Xtal structures: 9
Docked structures: 0
Catalog Cmpds: 50