Compile Data Set for Download or QSAR
maximum 50k data
Found 2642 with Last Name = 'hoffman' and Initial = 'd'
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170654((+-)-cis-4-(3-(4-tert-butylphenyl)-2-methylpropyl)...)
Affinity DataKi:  0.0100nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230127(CHEMBL407606)
Affinity DataKi:  0.0245nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170652((2R,6S)-2,6-Dimethyl-4-tridecyl-morpholine | CHEMB...)
Affinity DataKi:  0.0400nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230129(CHEMBL407123)
Affinity DataKi:  0.0427nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170654((+-)-cis-4-(3-(4-tert-butylphenyl)-2-methylpropyl)...)
Affinity DataKi:  0.0500nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230120(CHEMBL405737)
Affinity DataKi:  0.0776nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170652((2R,6S)-2,6-Dimethyl-4-tridecyl-morpholine | CHEMB...)
Affinity DataKi:  0.0900nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230123(CHEMBL385042)
Affinity DataKi:  0.0933nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50047016(1-(4-Fluoro-phenyl)-4-[4-hydroxy-4-(3-trifluoromet...)
Affinity DataKi:  0.150nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230122(CHEMBL415571)
Affinity DataKi:  0.155nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230126(CHEMBL385468)
Affinity DataKi:  0.186nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170651((3S,8R,9S,10R,13S,14S)-3-(2-Diethylamino-ethoxy)-1...)
Affinity DataKi:  0.200nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170636(2-[4-(3-Dibenzo[b,f]azepin-5-yl-propyl)-piperazin-...)
Affinity DataKi:  0.200nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50272695(3-(4-chloro-2-morpholinothiazol-5-yl)-2,6-dimethyl...)
Affinity DataKi:  0.200nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.200nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230124(CHEMBL429240)
Affinity DataKi:  0.209nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
German National Research Center For Information Technology

Curated by ChEMBL
LigandPNGBDBM50082040((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.270nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230128(CHEMBL437798)
Affinity DataKi:  0.380nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50003027((4aS,5S,6S,8aS)-5,8a-Dimethyl-2-(1,5,9-trimethyl-d...)
Affinity DataKi:  0.400nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.5nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170650((2-{4-[(2-Chloro-benzylamino)-methyl]-cyclohexyl}-...)
Affinity DataKi:  0.5nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50003027((4aS,5S,6S,8aS)-5,8a-Dimethyl-2-(1,5,9-trimethyl-d...)
Affinity DataKi:  0.5nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50003027((4aS,5S,6S,8aS)-5,8a-Dimethyl-2-(1,5,9-trimethyl-d...)
Affinity DataKi:  0.600nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170657(1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-p...)
Affinity DataKi:  0.600nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170656(CHEMBL190631 | [2-(4-{(E)-2-[4-(2-Diethylamino-eth...)
Affinity DataKi:  0.700nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50047016(1-(4-Fluoro-phenyl)-4-[4-hydroxy-4-(3-trifluoromet...)
Affinity DataKi:  0.830nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50065941(1-{2-[4-(6-Methoxy-2-phenyl-3,4-dihydro-naphthalen...)
Affinity DataKi:  0.900nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50132951(8-(2,4-dichlorophenyl)-2-methyl-N,N-dipropylquinol...)
Affinity DataKi:  0.900nMAssay Description:Antagonist activity at human CRF-1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50132951(8-(2,4-dichlorophenyl)-2-methyl-N,N-dipropylquinol...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170651((3S,8R,9S,10R,13S,14S)-3-(2-Diethylamino-ethoxy)-1...)
Affinity DataKi:  1nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM55354(CLOMIPHENE | CLOMIPHENE CITRATE | MLS000069760 | S...)
Affinity DataKi:  1nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50080017((+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-...)
Affinity DataKi:  1nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170657(1''-butyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-p...)
Affinity DataKi:  1nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170652((2R,6S)-2,6-Dimethyl-4-tridecyl-morpholine | CHEMB...)
Affinity DataKi:  1nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM19441(2-(4-hydroxyphenyl)-3-({4-[2-(piperidin-1-yl)ethox...)
Affinity DataKi:  1nMAssay Description:Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170659(2-[3-(Methyl-phenethyl-amino)-propyl]-2-phenyl-tet...)
Affinity DataKi:  1nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataKi:  1nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM18957((2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-di...)
Affinity DataKi:  1nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170648((R)-2-Isopropyl-5-(methyl-phenethyl-amino)-2-pheny...)
Affinity DataKi:  1nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50348782(CHEMBL1807053)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1nMAssay Description:Binding affinity towards Dopamine type 2 receptor was determined by displacement assays using [3H]-YM 09151 as the competitive ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50348778(CHEMBL1807058)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50170639(Benzothiazol-2-yl-methyl-[1-(4-phenoxy-butyl)-pyrr...)
Affinity DataKi:  1.30nMAssay Description:Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50348829(CHEMBL1807054)
Affinity DataKi:  1.30nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLutropin-choriogonadotropic hormone receptor(Rattus norvegicus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50230130(CHEMBL266205)
Affinity DataKi:  1.40nMAssay Description:Negative logarithm of equilibrium dissociation constant in the rat pituitary luteinizing releasing hormone receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50348783(CHEMBL1807052)
Affinity DataKi:  1.40nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCorticotropin-releasing factor receptor 1(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50348786(CHEMBL1807049)
Affinity DataKi:  1.90nMAssay Description:Displacement of [125I]-sauvagine from human CRF-1 receptor expressed in human IMR-32 cells after 2 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Neurogen

Curated by ChEMBL
LigandPNGBDBM50119970(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-((R)-2-me...)
Affinity DataKi:  2nMAssay Description:Binding affinity towards Dopamine receptor D4 was determined via standard competitive displacement assays using [3H]-YM 09151 as the competitive liga...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-8 sterol isomerase ERG2(Saccharomyces cerevisiae)
University Of Innsbruck

Curated by ChEMBL
LigandPNGBDBM71545(2-[4-[(Z)-2-chloranyl-1,2-diphenyl-ethenyl]phenoxy...)
Affinity DataKi:  2nMAssay Description:Affinity for ERG2 of Sacchromyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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