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Found 42 with Last Name = 'hoffner' and Initial = 's'
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385299(CHEMBL2035464 | US8592468, EbSe16)
Affinity DataKi:  10nM IC50:  2.25E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385302(CHEMBL2035461 | US8592468, EbSe15)
Affinity DataKi:  40nM IC50:  2.10E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM50385303(CHEMBL2035460 | US8592468, EbSe14)
Affinity DataKi:  50nM IC50:  2.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106948(US8592468, EbSe12)
Affinity DataKi:  250nM IC50:  3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106941(US8592468, EbSe8)
Affinity DataKi:  250nM IC50:  6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM34233(2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-ben...)
Affinity DataKi:  300nM IC50:  6.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106940(US8592468, EbSe7)
Affinity DataKi:  550nM IC50:  7.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106944(US8592468, EbSe2)
Affinity DataKi:  1.00E+3nM IC50:  1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106942(US8592468, EbSe9)
Affinity DataKi:  1.20E+3nM IC50:  7.50E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106949(US8592468, EbSe13)
Affinity DataKi:  1.50E+3nM IC50:  3.00E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106943(US8592468, EbSe10 | acs.jmedchem.1c00409_ST.159)
Affinity DataIC50:  1.50E+3nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018442(CHEMBL3286436)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018290(CHEMBL3290338)
Affinity DataIC50:  5.30E+3nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018440(CHEMBL3290342)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018444(CHEMBL3290345)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018447(CHEMBL3290347)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106945(US8592468, EbSe3)
Affinity DataIC50:  1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106946(US8592468, EbSe4)
Affinity DataIC50:  1.50E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018288(CHEMBL3290336)
Affinity DataIC50:  2.10E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018407(CHEMBL3290339)
Affinity DataIC50:  2.60E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018441(CHEMBL3290343)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase(Escherichia coli (strain K12))
Thioredoxin Systems

US Patent
LigandPNGBDBM106947(US8592468, EbSe11)
Affinity DataIC50: >4.00E+4nMAssay Description:All the benzisoselenazol-3(2H)-one and bisbenzisoselenazol-3(2H)-one derivatives were tested as potential E. coli TrxR inhibitors by standard DTNB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395400(CHEMBL2165062)
Affinity DataIC50:  4.40E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018439(CHEMBL3290341)
Affinity DataIC50:  5.06E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018422(CHEMBL3290340)
Affinity DataIC50:  6.90E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018446(CHEMBL3290346)
Affinity DataIC50:  6.90E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018443(CHEMBL3290344)
Affinity DataIC50:  7.40E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018483(CHEMBL3290351)
Affinity DataIC50:  9.00E+4nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018407(CHEMBL3290339)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase-B ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018290(CHEMBL3290338)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase-B ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018289(CHEMBL3290337)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase-B ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018288(CHEMBL3290336)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase-B ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit B(Mycobacterium smegmatis)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50395400(CHEMBL2165062)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Mycobacterium smegmatis DNA gyrase-B ATPase activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018489(CHEMBL3290357)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018488(CHEMBL3290356)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018487(CHEMBL3290355)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018486(CHEMBL3290354)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018485(CHEMBL3290353)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018448(CHEMBL3290348)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018481(CHEMBL3290349)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018482(CHEMBL3290350)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50018484(CHEMBL3290352)
Affinity DataIC50:  1.51E+5nMAssay Description:Inhibition of human ERG by patch clamp electrophysiological analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed