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Target
Thioredoxin reductase
Ligand
BDBM34233
Substrate
n/a
Meas. Tech.
Inhibition Assay
Ki
3.0e+2±n/a nM
IC50
6e+3±n/a nM
Citation
 Holmgren, A; Lu, J; Vlamis-Gardikas, A; Zhao, R; Kandasamy, K; Engman, L; Engstrand, L; Hoffner, S Bacterial thioredoxin reductase inhibitors and methods for use thereof US Patent  US8592468 Publication Date 11/26/2013 
Target
Name:
Thioredoxin reductase
Synonyms:
TRXB_ECOLI | Thioredoxin reductase (TrxR) | trxB
Type:
Protein
Mol. Mass.:
34615.59
Organism:
Escherichia coli (strain K12)
Description:
P0A9P4
Residue:
321
Sequence:
MGTTKHSKLLILGSGPAGYTAAVYAARANLQPVLITGMEKGGQLTTTTEVENWPGDPNDLTGPLLMERMHEHATKFETEIIFDHINKVDLQNRPFRLNGDNGEYTCDALIIATGASARYLGLPSEEAFKGRGVSACATCDGFFYRNQKVAVIGGGNTAVEEALYLSNIASEVHLIHRRDGFRAEKILIKRLMDKVENGNIILHTNRTLEEVTGDQMGVTGVRLRDTQNSDNIESLDVAGLFVAIGHSPNTAIFEGQLELENGYIKVQSGIHGNATQTSIPGVFAAGDVMDHIYRQAITSAGTGCMAALDAERYLDGLADAK
  
Inhibitor
Name:
BDBM34233
Synonyms:
2-Phenyl-benzo[d]isoselenazol-3-one | 2-Phenyl-benzo[d]isoselenazol-3-one(Ebselen) | 2-phenyl-1,2-benzisoselazol-3(2H)-one | 2-phenyl-1,2-benzoselenazol-3-one | 2-phenylbenzo[d][1,2]selenazol-3(2H)-one | CHEMBL51085 | EBSELEN | Ebselen (C5) | MLS000028488 | SMR000058445 | cid_3194 | med.21724, Compound 153
Type:
Small organic molecule
Emp. Form.:
C13H9NOSe
Mol. Mass.:
274.18
SMILES:
O=c1n([se]c2ccccc12)-c1ccccc1
Structure:
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