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Found 400 with Last Name = 'huggett' and Initial = 'm'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333952(CHEMBL1644470 | exo-(1R,5S)-3-(6-phenylpyridin-2-y...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417843(CHEMBL1667967)
Affinity DataKi:  2.51nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  25.1nMAssay Description:Inhibition of ROCK-1More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14031(5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...)
Affinity DataKi:  31.6nMAssay Description:Inhibition of ROCK-1More data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417844(CHEMBL1667963)
Affinity DataKi:  34.7nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417668(CHEMBL1643368)
Affinity DataKi:  37.1nMAssay Description:Binding affinity to ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417674(CHEMBL1643361)
Affinity DataKi:  63.1nMAssay Description:Inhibition of ROCK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataKi:  100nMAssay Description:Inhibition of ROCK-1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333972(CHEMBL1644605 | exo-2-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataKi:  119nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417667(CHEMBL1643574)
Affinity DataKi:  794nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333954(CHEMBL1644611 | exo-3-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataKi:  1.62E+3nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417674(CHEMBL1643361)
Affinity DataKi:  3.16E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333953(2-(3-((1R,5S)-8-azabicyclo[3.2.1]octan-3-yloxy)-5-...)
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333976(CHEMBL1644609 | exo-2-(6-((1R,5S)-8-azabicyclo[3.2...)
Affinity DataKi:  7.08E+3nMAssay Description:Inhibition of human ERG by dofetilide binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14031(5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinoli...)
Affinity DataKi:  7.94E+3nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417668(CHEMBL1643368)
Affinity DataKi:  2.00E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14027(5-(1,4-diazepan-1-ylsulfonyl)isoquinoline | 5-(1,4...)
Affinity DataKi:  2.51E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM14029((R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXA...)
Affinity DataKi:  7.94E+4nMAssay Description:Displacement of [3H]dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50417843(CHEMBL1667967)
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599123(CHEMBL5170226)
Affinity DataIC50:  4.70nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599123(CHEMBL5170226)
Affinity DataIC50:  4.70nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599096(CHEMBL5186088)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599096(CHEMBL5186088)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333975(CHEMBL1644608 | exo-3'-((1R,5S)-8-azabicyclo[3.2.1...)
Affinity DataIC50:  5nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599101(CHEMBL5180818)
Affinity DataIC50:  5.20nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599101(CHEMBL5180818)
Affinity DataIC50:  5.20nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599063(CHEMBL5171669)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599063(CHEMBL5171669)
Affinity DataIC50:  7.20nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599077(CHEMBL5207823)
Affinity DataIC50:  8.5nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599077(CHEMBL5207823)
Affinity DataIC50:  8.5nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599097(CHEMBL5172567)
Affinity DataIC50:  8.70nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599097(CHEMBL5172567)
Affinity DataIC50:  8.70nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333976(CHEMBL1644609 | exo-2-(6-((1R,5S)-8-azabicyclo[3.2...)
Affinity DataIC50:  9nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599141(CHEMBL5172502)
Affinity DataIC50:  9.80nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599141(CHEMBL5172502)
Affinity DataIC50:  9.80nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599105(CHEMBL5181240)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599105(CHEMBL5181240)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333960(CHEMBL1644477 | exo-(1R,5S)-3-(3-iodophenoxy)-8-az...)
Affinity DataIC50:  12nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599062(CHEMBL5180892)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599062(CHEMBL5180892)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333977(CHEMBL1644610 | exo-2-((1R,5S)-8-azabicyclo[3.2.1]...)
Affinity DataIC50:  13nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333959(CHEMBL1644476 | exo-(1R,5S)-3-(3-bromophenoxy)-8-a...)
Affinity DataIC50:  13nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599064(CHEMBL5204521)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599064(CHEMBL5204521)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599099(CHEMBL5191540)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599099(CHEMBL5191540)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599076(CHEMBL5186601)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599076(CHEMBL5186601)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Glasgow

Curated by ChEMBL
LigandPNGBDBM50599065(CHEMBL5191278)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at human Galphai2-fused GPR84 stably expressed in Flp-In-T-REx-293 cell membranes assessed as inhibition of PSB-16671-induced [35...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Msd

Curated by ChEMBL
LigandPNGBDBM50333957(CHEMBL1644474 | exo-(1R,5S)-3-(3-chlorophenoxy)-8-...)
Affinity DataIC50:  19nMAssay Description:Inhibition of [3H]noradrenalin reuptake at NET expressed in MDCK cells scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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