Affinity DataKi: <0.0500nMAssay Description:Inhibition of Escherichia coli DNA gyrase BMore data for this Ligand-Target Pair
Affinity DataKi: 0.129nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.138nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)p...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.182nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.195nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Dainippon Pharmaceutical
Curated by ChEMBL
Dainippon Pharmaceutical
Curated by ChEMBL
Affinity DataKi: 0.200nMAssay Description:Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 0.240nMAssay Description:Binding affinity to human neurotensin receptor 1More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.257nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 0.257nMAssay Description:Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.269nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 0.275nMAssay Description:Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.355nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)p...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 0.363nMAssay Description:Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by ...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nM ΔG°: -55.8kJ/mole EC50: 4.5nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.447nMAssay Description:Displacement of [3H]-NMS from human muscarinic M4 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.510nMAssay Description:Binding affinity to human neurotensin receptor 1More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.525nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.525nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 0.575nMAssay Description:Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.589nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.589nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-1-(6-((3,5-Bis((2-(3-(1-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)piperidin-4...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.631nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nM ΔG°: -54.4kJ/mole EC50: 0.290nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 0.741nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation co...More data for this Ligand-Target Pair
Affinity DataKi: 0.759nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.794nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Dainippon Pharmaceutical
Curated by ChEMBL
Dainippon Pharmaceutical
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Dainippon Pharmaceutical
Curated by ChEMBL
Dainippon Pharmaceutical
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Inhibition of [3H]GR-65630 binding to rat cortical membrane serotonin 5-hydroxytryptamine 3 receptorMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.912nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor expressed in CHO-K9 cells measured after 60 mins by Hoechst H33342 dye based confocal plat...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 0.933nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.955nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation co...More data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -53.4kJ/mole EC50: 0.400nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
Affinity DataKi: 1nM ΔG°: -53.4kJ/mole EC50: 53.3nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...More data for this Ligand-Target Pair
TargetNeuropeptide Y receptor type 1(Homo sapiens (Human))
Monash University (Parkville Campus)
Curated by ChEMBL
Monash University (Parkville Campus)
Curated by ChEMBL
Affinity DataKi: 1nMAssay Description:Displacement of (sCy5)-[Lys2 Arg4]-BVD15 from GFP-tagged Y1R in human HEK293T cells assessed as inhibitory constant incubated for 5 mins followed by ...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 1.10nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 2 in HEK293 cells homogenate incubated in dark after 30 mins by liquid scintillation co...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT6 receptor expressed in HEK293 cells after 60 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Displacement of 4-(2-((1E,3E)-5-((E)-3,3-Dimethyl-1-(6-oxo-6-((2-(4-(4-(1-(2-oxo-2-(11-oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-5-yl)ethyl)pipe...More data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of human recombinant MMP12 using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Binding affinity to human neurotensin receptor 1More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 1 stably expressed in CHO cells incubated in dark after 30 mins by liquid scintillation...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H] UR-MK300 from human neurotensin receptor 1 expressed in HT-29 cells incubated in dark after 30 mins by liquid scintillation coun...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of Regensburg
Curated by ChEMBL
University Of Regensburg
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Displacement of [3H]-NMS from human muscarinic M2 receptor stably expressed in CHO-K9 cells by radioligand competitive binding assayMore data for this Ligand-Target Pair