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Found 74 with Last Name = 'james' and Initial = 'jk'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155694(1-{2-Hydroxy-3-methyl-4-[3-(pyridin-4-ylsulfanylme...)
Affinity DataEC50:  819nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155695(1-{2-Hydroxy-3-methyl-4-[2-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  677nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155696(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  578nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155697(1-[3-Bromo-2-hydroxy-4-(4-phenoxy-butoxy)-phenyl]-...)
Affinity DataEC50:  1.50E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155698(1-{3-Bromo-2-hydroxy-4-[4-(pyridin-4-ylsulfanyl)-b...)
Affinity DataEC50:  676nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155699(1-{3-Bromo-4-[4-(2,3-difluoro-phenoxy)-butoxy]-2-h...)
Affinity DataEC50:  558nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155701(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  340nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155700(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-3-yloxy)-butox...)
Affinity DataEC50:  1.72E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155702(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-2-yloxy)-butox...)
Affinity DataEC50:  3.27E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50130608(2,2,2-Trifluoro-ethanesulfonic acid [4-(2-methoxy-...)
Affinity DataEC50:  1.70E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155703(1-{2-Hydroxy-3-methyl-4-[3-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  890nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153757(1-(2-Hydroxy-3-propyl-4-{4-[4-(1H-tetrazol-5-yl)-p...)
Affinity DataEC50:  348nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155704(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-4-yloxy)-butox...)
Affinity DataEC50:  3.86E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155705(1-[2-Hydroxy-3-methyl-4-(4-phenoxy-butoxy)-phenyl]...)
Affinity DataEC50:  4.55E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155706(1-{4-[4-(2,3-Difluoro-phenoxy)-butoxy]-2-hydroxy-3...)
Affinity DataEC50:  384nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155707(1-{2-Hydroxy-3-methyl-4-[4-(4-[1,2,4]triazol-1-yl-...)
Affinity DataEC50:  4.24E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50153752(1-(2-Hydroxy-3-methyl-4-{4-[4-(1H-tetrazol-5-yl)-p...)
Affinity DataEC50:  229nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155709(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-4-ylsulfanylme...)
Affinity DataEC50:  770nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155712(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-3-ylsulfanyl)-...)
Affinity DataEC50:  1.09E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155708(1-{4-[4-(2-Fluoro-phenoxy)-butoxy]-2-hydroxy-3-met...)
Affinity DataEC50:  1.99E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155711(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-4-ylsulfanyl)-...)
Affinity DataEC50:  1.06E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155713(1-{2-Hydroxy-3-methyl-4-[4-(pyridin-2-ylsulfanyl)-...)
Affinity DataEC50:  1.53E+3nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50155710(1-{3-Bromo-2-hydroxy-4-[4-(pyridin-3-yloxy)-butoxy...)
Affinity DataEC50:  575nMAssay Description:Binding affinity towards human metabotropic glutamate receptor 2 determined by [35S]-GTP gama S binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162556(6,7-Dichloro-2-isopropyl-5-[3-(pyridin-4-ylsulfany...)
Affinity DataEC50:  839nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162558(6,7-Dichloro-2-cyclopentyl-2-methyl-5-{4-[4-(2H-te...)
Affinity DataEC50:  225nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162557((+/-)-4-(6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo...)
Affinity DataEC50:  892nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162559(6,7-Dimethyl-2-propyl-5-[3-(pyridin-4-ylsulfanylme...)
Affinity DataEC50:  291nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162560(CHEMBL369526 | N-[4-(6,7-Dichloro-2-cyclopentyl-2-...)
Affinity DataEC50:  515nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162561(6,7-Dichloro-2-cyclopentyl-2-methyl-5-[3-(2H-tetra...)
Affinity DataEC50:  5.00E+3nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162562(6,7-Dichloro-2-methyl-2-phenyl-5-[4-(2H-tetrazol-5...)
Affinity DataEC50:  629nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162563(6,7-Dichloro-2-cyclopentyl-2-methyl-5-{3-[4-(2H-te...)
Affinity DataEC50:  270nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162564(6,7-Dichloro-2-cyclopentyl-2-methyl-5-[4-(2H-tetra...)
Affinity DataEC50:  589nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162565(6,7-Dichloro-2-propyl-5-[3-(pyridin-4-ylsulfanylme...)
Affinity DataEC50:  186nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162567(6,7-Dichloro-2-cyclopentyl-2-methyl-5-{2-[4-(2H-te...)
Affinity DataEC50:  1.16E+3nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162566(6,7-Dichloro-2-propyl-5-[4-(2H-tetrazol-5-yl)-benz...)
Affinity DataEC50:  282nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162568(6,7-Dichloro-2-cyclopentyl-5-[4-(2H-tetrazol-5-yl)...)
Affinity DataEC50:  122nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162570(2-(6,7-Dichloro-2-cyclopentyl-2-methyl-1-oxo-indan...)
Affinity DataEC50:  600nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162569(6,7-Dichloro-2-cyclopentyl-2-methyl-5-[4-(2H-tetra...)
Affinity DataEC50:  223nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162573(6,7-Dichloro-2-isopropyl-5-[4-(2H-tetrazol-5-yl)-b...)
Affinity DataEC50:  195nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162571(CHEMBL180455 | N-Acetyl-4-(6,7-dichloro-2-cyclopen...)
Affinity DataEC50:  442nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162572(6,7-Dichloro-2-cyclopentyl-5-[3-(pyridin-4-ylsulfa...)
Affinity DataEC50:  165nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162577(6,7-Dichloro-2-cyclopentyl-2-methyl-5-{2-[4-(2H-te...)
Affinity DataEC50:  276nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162575(6,7-Dichloro-2-cyclopentyl-2-methyl-5-[3-(pyridin-...)
Affinity DataEC50:  562nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162576(2-Butyl-6,7-dichloro-2-cyclopentyl-5-[4-(2H-tetraz...)
Affinity DataEC50:  1.09E+3nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162574(6,7-Dichloro-2-cyclopentyl-2-methyl-5-[3-(2H-tetra...)
Affinity DataEC50:  371nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162579(2-Cyclopentyl-6,7-dimethyl-5-[3-(pyridin-4-ylsulfa...)
Affinity DataEC50:  596nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162578(6,7-Dichloro-2,2-dimethyl-5-[4-(2H-tetrazol-5-yl)-...)
Affinity DataEC50:  782nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50162580(6,7-Dichloro-2-cyclopentyl-2-methyl-5-[5-(2H-tetra...)
Affinity DataEC50:  761nMAssay Description:Binding affinity against metabotropic glutamate receptor 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170306(1-(2,2-Dimethyl-propyl)-4-propyl-5-[4'-(1H-tetrazo...)
Affinity DataEC50:  318nMAssay Description:Effective concentration for stimulation of [35S]-GTP-gammaS, binding to human metabotropic glutamate receptor 2 incubated at 30 degree C for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50170307(3-(2,2-Dimethyl-propyl)-7-propyl-6-{4-[4-(1H-tetra...)
Affinity DataEC50:  788nMAssay Description:Effective concentration for stimulation of [35S]-GTP-gammaS, binding to human metabotropic glutamate receptor 2 incubated at 30 degree C for 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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