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Found 1390 with Last Name = 'kassiou' and Initial = 'm'
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390197(CHEMBL1917286)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390205(CHEMBL2069863)
Affinity DataKi:  0.100nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390207(CHEMBL2069865)
Affinity DataKi:  0.120nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073602(CHEMBL3408973)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390206(CHEMBL2069864)
Affinity DataKi:  0.152nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50324100(CHEMBL1214830 | N-((Benzofuran-2-yl)methyl)-N'-(4'...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50324097(CHEMBL1214831 | N-(Benzofuran-2-ylmethyl)-N'-(4'-e...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390204(CHEMBL2069862)
Affinity DataKi:  0.194nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50589230(CHEMBL5181634)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]-2MesADP from human P2Y12 in HEK cell membrane assessed as inhibition constant incubated for 1 hr by scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073596(CHEMBL3408967)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50350912(CHEMBL1817978)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM98172(US8492379, 28)
Affinity DataKi:  0.450nMAssay Description:In vitro binding activity of TSPO.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM98171(US8492379, 27)
Affinity DataKi:  0.460nMAssay Description:In vitro binding activity of TSPO.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073597(CHEMBL3408968)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50178936(2-(2-((dimethylamino)methyl)phenoxy)-5-methylbenze...)
Affinity DataKi:  0.530nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50390203(CHEMBL2069861)
Affinity DataKi:  0.540nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334158(1'-benzyl-3-(2-fluoroethyl)-3H-spiro[[2]benzofuran...)
Affinity DataKi:  0.590nMAssay Description:Binding affinity to sigma 1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073600(CHEMBL3408971)
Affinity DataKi:  0.670nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50229594(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of rat TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073598(CHEMBL3408969)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50205990(CHEMBL395429 | OXYTOCIN)
Affinity DataKi:  0.800nMAssay Description:Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50303527((2,2,3,3-Tetramethylcyclopropyl)(1-(4,4,4-trifluor...)
Affinity DataKi:  0.830nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in CHO cell membrane incubated for 1 hr by liquid scintillation spectrophotometric anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073591(CHEMBL3408960)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073588(CHEMBL3408974)
Affinity DataKi:  0.870nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in rat brain homogenateMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50185957(CHEMBL205767 | N-(2-isopropoxybenzyl)-N-(4-chloro-...)
Affinity DataKi:  0.920nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM98173(US8492379, 29)
Affinity DataKi:  0.970nMAssay Description:In vitro binding activity of TSPO.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073595(CHEMBL3408966)
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Affinity DataKi:  1nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor expressed in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataKi:  1.03nMAssay Description:Displacement of [3H](+)-pentazocine from sigma 1 receptor in rat brain homogenateMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50327234(2-[2-(4'-Butoxy1phenyl)-5,7-dimethylpyrazolo[1,5-a...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50350912(CHEMBL1817978)
Affinity DataKi:  1.19nMAssay Description:Displacement of [3H]PK11195 from TSPO in human HEK293 mitochondrial fractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50334458(CHEMBL1643901 | N-(3-Fluorobenzyl)-N-methyl-8-amin...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]WIN-35428 form human DAT expressed in HEK cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50374598(CHEMBL272603 | US9604926, Compound CM-156 | US9724...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenate after 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50327236(2-[5,7-Dimethyl-2-(4'-propoxyphenyl)pyrazolo[1,5-a...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat kidneyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073599(CHEMBL3408970)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50068454(1-[2-(3-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity to sigma1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073603(CHEMBL3408963)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50008984(4-(4-Chloro-benzyl)-2-(1-methyl-azepan-4-yl)-2H-ph...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor measured after 2 hrs by competitive binding assayMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073592(CHEMBL3408961)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM98176(US8492379, 53)
Affinity DataKi:  1.55nMAssay Description:In vitro binding activity of TSPO.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073601(CHEMBL3408972)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50324086(CHEMBL1214893 | N-(Benzofuran-2-ylmethyl)-N'-(4'-(...)
Affinity DataKi:  1.61nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in guinea pig brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.65nMAssay Description:Displacement of [3H]paroxetine from SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]PK11195 from TSPO in rat heart membrane homogenateMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073604(CHEMBL3408964)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2B(Rattus norvegicus (Rat))
The University Of Sydney

Curated by ChEMBL
LigandPNGBDBM50124908(CHEMBL159560 | N-(2-Methoxy-benzyl)-4-trifluoromet...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]ifenprodil from Wistar rat GluN2B receptor after 2 hrs by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073589(CHEMBL3408958)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073590(CHEMBL3408959)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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