Compile Data Set for Download or QSAR
maximum 50k data
Found 641 with Last Name = 'khlebnikov' and Initial = 'ai'
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23698(4-chloro-1-[(4-fluorophenyl)carbonyl]-1H-pyrazole ...)
Affinity DataKi:  6nM ΔG°:  -46.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23700(N-Benzoylpyrazole deriv., 2 | methyl 1-[(4-chlorop...)
Affinity DataKi:  15nM ΔG°:  -44.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM50466430(CHEMBL4283747)
Affinity DataKi:  16nMAssay Description:Competitive inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate by Dixon plot analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23709(3-methyl-1-[(3,4,5-trimethoxyphenyl)carbonyl]-1H-p...)
Affinity DataKi:  21nM ΔG°:  -43.8kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23702(3-[(2,4-dimethylphenyl)carbonyl]-1-[(4-fluoropheny...)
Affinity DataKi:  24nM ΔG°:  -43.5kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23701(4-chloro-1-[(3-nitrophenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  24nM ΔG°:  -43.5kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23710(1-[(4-methylphenyl)carbonyl]-3-nitro-1H-pyrazole |...)
Affinity DataKi:  28nM ΔG°:  -43.1kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23703(1-benzoyl-4-nitro-1H-pyrazole | N-Benzoylpyrazole ...)
Affinity DataKi:  34nM ΔG°:  -42.6kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23704(1-benzoyl-N-phenyl-1H-pyrazole-3-carboxamide | N-B...)
Affinity DataKi:  39nM ΔG°:  -42.3kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23705(4-bromo-1-[(4-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  45nM ΔG°:  -41.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23711(1-benzoyl-3-nitro-1H-pyrazole | N-Benzoylpyrazole ...)
Affinity DataKi:  46nM ΔG°:  -41.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM50466438(CHEMBL4289821)
Affinity DataKi:  51nMAssay Description:Competitive inhibition of human neutrophil elastase using N-methylsuccinyl-Ala-Ala-Pro-Val-7-amino-4-methylcoumarin as substrate by Dixon plot analys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23712(1-[(2-methylphenyl)carbonyl]-4-nitro-1H-pyrazole |...)
Affinity DataKi:  65nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23706(1-[(3,4-dichlorophenyl)carbonyl]-1H-pyrazole | N-B...)
Affinity DataKi:  104nM ΔG°:  -39.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23707(1-[(2-fluorophenyl)carbonyl]-5-methyl-3-nitro-1H-p...)
Affinity DataKi:  107nM ΔG°:  -39.8kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23726(1,1-dimethylprop-2-yn-1-yl 4-methoxybenzoate, 10 |...)
Affinity DataKi:  110nM ΔG°:  -39.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23713(4-chloro-1-[(2-methylphenyl)carbonyl]-1H-pyrazole ...)
Affinity DataKi:  230nM ΔG°:  -37.9kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23714(4-bromo-1-[(3-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  250nM ΔG°:  -37.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23727(N,N-bis(cyanomethyl)-3,4-dimethoxybenzamide | N,N-...)
Affinity DataKi:  290nM ΔG°:  -37.3kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23716(N-Benzoylpyrazole deriv., 24 | N-{4-[(3-methyl-1H-...)
Affinity DataKi:  300nM ΔG°:  -37.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23715(4-bromo-1-[(2-methylphenyl)carbonyl]-1H-pyrazole |...)
Affinity DataKi:  300nM ΔG°:  -37.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11976(5-chloro-2-(5-{[(4E)-3,8-dioxo-5,16-dithia-2,7-dia...)
Affinity DataKi:  800nM ΔG°:  -35.0kJ/mole IC50:  1.10E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23728(2-(2-methoxyphenoxy)-N'-(thiophen-2-ylcarbonyl)ace...)
Affinity DataKi:  820nM ΔG°:  -34.7kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11983(3-(4-chlorophenyl)-1-{4-[(5-ethyl-1,3,4-thiadiazol...)
Affinity DataKi:  900nM ΔG°:  -34.7kJ/mole IC50:  4.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11996(2-[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]acetic ac...)
Affinity DataKi:  900nM ΔG°:  -34.7kJ/mole IC50:  7.60E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, the concentrations of inhibitor that caused 50% inhibition of enzymati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11989(2-chloro-5-[(4Z)-3-methyl-5-oxo-4-{[4-(propan-2-yl...)
Affinity DataKi:  900nM ΔG°:  -34.7kJ/mole IC50:  8.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23717(4-chloro-1-[(2-chlorophenyl)carbonyl]-1H-pyrazole ...)
Affinity DataKi:  1.00E+3nM ΔG°:  -34.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11980((5Z)-5-[(2,4-dihydroxyphenyl)methylidene]-2-sulfan...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.2kJ/mole IC50:  3.70E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23708(4-bromo-1-[(2,6-difluorophenyl)carbonyl]-1H-pyrazo...)
Affinity DataKi:  1.10E+3nM ΔG°:  -34.0kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11985(4-(2,5-dimethyl-1H-pyrrol-1-yl)-2-hydroxybenzoic a...)
Affinity DataKi:  1.50E+3nM ΔG°:  -33.5kJ/mole IC50:  3.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11977(5-bromo-2-(5-{[(4Z)-1-(3-carboxyphenyl)-5-oxo-3-(t...)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.3kJ/mole IC50:  1.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11994(2-{[4-(2,5-dimethyl-1H-pyrrol-1-yl)phenyl]sulfanyl...)
Affinity DataKi:  1.60E+3nM ΔG°:  -33.3kJ/mole IC50:  2.90E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, the concentrations of inhibitor that caused 50% inhibition of enzymati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23730(1,2,4-triazole-5-carboxylate, 14 | methyl 3-[2-(1,...)
Affinity DataKi:  1.60E+3nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11991(8-{N-[4-(2,3-dihydro-1,3-thiazol-2-ylsulfamoyl)phe...)
Affinity DataKi:  1.80E+3nM ΔG°:  -33.0kJ/mole IC50:  8.70E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11993(2-chloro-5-[(4Z)-4-{[5-(4-chlorophenyl)furan-2-yl]...)
Affinity DataKi:  2.10E+3nM ΔG°:  -32.6kJ/mole IC50:  1.00E+4nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11979(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.3kJ/mole IC50:  2.90E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11984(2-chloro-4-{5-[N-(3-cyano-4,5,6,7-tetrahydro-1-ben...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.3kJ/mole IC50:  5.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11981(2-chloro-5-{[(4Z)-4-{[4-(methylsulfanyl)phenyl]met...)
Affinity DataKi:  2.50E+3nM ΔG°:  -32.2kJ/mole IC50:  3.30E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23731(4-methoxy-N -(phenylacetyl)benzohydrazide | 4-meth...)
Affinity DataKi:  2.50E+3nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11978((1E,6E)-4-(1,3-dithian-2-ylidene)-1,7-bis(furan-2-...)
Affinity DataKi:  2.70E+3nM ΔG°:  -32.0kJ/mole IC50:  3.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11982(2-{[(2-amino-2-carboxyethyl)sulfanyl]methyl}-5-phe...)
Affinity DataKi:  2.90E+3nM ΔG°:  -31.8kJ/mole IC50:  4.10E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11987(2-hydroxy-5-(5-{[(5Z)-2-imino-4-oxo-3-(1,3-thiazol...)
Affinity DataKi:  3.10E+3nM ΔG°:  -31.7kJ/mole IC50:  4.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23732(3-(2-chlorophenyl)-5-methyl-4-(1H-pyrazol-1-ylcarb...)
Affinity DataKi:  3.10E+3nMAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11986(3-[(5E)-5-[(3-bromo-4-methoxyphenyl)methylidene]-4...)
Affinity DataKi:  3.30E+3nM ΔG°:  -31.5kJ/mole IC50:  4.70E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23718(1-[(2-methylphenyl)carbonyl]-1H-pyrazole | N-Benzo...)
Affinity DataKi:  3.40E+3nM ΔG°:  -31.2kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11988((5Z)-5-(1,3-benzothiazol-2-ylimino)-1-(4-sulfophen...)
Affinity DataKi:  4.20E+3nM ΔG°:  -30.9kJ/mole IC50:  9.20E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11990(4-(5-{[(3E)-5-cyano-2-hydroxy-4-methyl-6-oxo-3,6-d...)
Affinity DataKi:  5.40E+3nM ΔG°:  -30.3kJ/mole IC50:  1.08E+4nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11995(2-chloro-5-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic ac...)
Affinity DataKi:  5.60E+3nM ΔG°:  -30.2kJ/mole IC50:  6.80E+3nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, the concentrations of inhibitor that caused 50% inhibition of enzymati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLethal factor(Bacillus anthracis)
Montana State University

LigandPNGBDBM11992(3-(5-{[(4Z)-1-(3-chlorophenyl)-3,5-dioxopyrazolidi...)
Affinity DataKi:  7.20E+3nM ΔG°:  -29.5kJ/mole IC50:  1.39E+4nMpH: 7.2 T: 2°CAssay Description:For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Montana State University

LigandPNGBDBM23719(4-bromo-1-[(2-chloro-4,5-difluorophenyl)carbonyl]-...)
Affinity DataKi:  7.20E+3nM ΔG°:  -29.4kJ/molepH: 7.5 T: 2°CAssay Description:HTS was performed in black flat-bottom 96-well microtiter plates. The reaction was initiated by addition of elastase substrate to the reaction buffer...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 641 total ) | Next | Last >>
Jump to: