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Found 1837 with Last Name = 'lee' and Initial = 'i'
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50329410(CHEMBL1270323 | N-(2-(4-(benzo[d]isoxazol-3-yl)pip...)
Affinity DataKi:  0.340nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50329412(CHEMBL1270423 | N-[2-[4-(3-Cyanopyridin-2-yl)piper...)
Affinity DataKi:  0.930nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137400(((R)-2-Phenyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137398(((R)-2-(4-Hydroxy-phenyl)-1-{3-phenyl-1-[(4-piperi...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137394(((R)-2-(3H-Indol-3-yl)-1-{3-phenyl-1-[(4-piperidin...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137388(((R)-2-Methyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  1nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Sungkyunkwan University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50173647((E)-4-(4-(methylamino)styryl)phenol | 4-(4-(methyl...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease brain sectionsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137392(CHEMBL99195 | [(S)-1-((S)-1-Formyl-3-methylsulfany...)
Affinity DataKi:  1.30nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50329407(CHEMBL1270121 | N-[2-[4-(3-Cyanopyridin-2-yl)piper...)
Affinity DataKi:  1.52nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50329408(CHEMBL1270227 | N-[2-[4-(4-Chlorophenyl)piperazin-...)
Affinity DataKi:  1.76nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50329405(CHEMBL1270013 | N-(2-(4-(benzo[d]isoxazol-3-yl)pip...)
Affinity DataKi:  1.93nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137389(((R)-3-Methyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137393(CHEMBL353725 | {(S)-1-[(S)-1-Benzyl-2-(4-piperidin...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137395(CHEMBL170242 | {(S)-1-[(S)-1-Benzyl-2-(4-morpholin...)
Affinity DataKi:  2nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Sungkyunkwan University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50485236(BAY-949172 | CHEBI:79033 | FLORBETABEN F18 | Florb...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease brain sectionsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50329409(CHEMBL1270322 | N-[2-[4-(4-Methylphenyl)piperazin-...)
Affinity DataKi:  2.64nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Sungkyunkwan University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50484946((18F)AV-45 | 18F-AV-45 | AV-45 F-18 | Amyvid | CHE...)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to amyloid beta (1-42) aggregates in human Alzheimer's disease brain sectionsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50329413(CHEMBL1270516 | N-[2-[4-(5-Chloropyridin-2-yl)pipe...)
Affinity DataKi:  2.92nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137400(((R)-2-Phenyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137390(((R)-3-Methylsulfanyl-1-{3-phenyl-1-[(4-piperidin-...)
Affinity DataKi:  3nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173162(CHEMBL362954 | N'-(4,5-Dihydro-1H-imidazol-2-yl)-N...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137388(((R)-2-Methyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  4.10nMAssay Description:Binding affinity towards alpha-1A adrenergic receptor expressed in human embryonic kidney (HEK293) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173165(CHEMBL194323 | N'-(4,5-Dihydro-oxazol-2-yl)-N-(3-m...)
Affinity DataKi:  4.20nMAssay Description:Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173163(3-[N'-(4,5-Dihydro-oxazol-2-yl)-N-p-tolyl-hydrazin...)
Affinity DataKi:  4.70nMAssay Description:Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50068366(CHEMBL93403 | N-{2-[4-(4-Chloro-phenyl)-piperazin-...)
Affinity DataKi:  4.97nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137389(((R)-3-Methyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  5nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173163(3-[N'-(4,5-Dihydro-oxazol-2-yl)-N-p-tolyl-hydrazin...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity towards alpha-1A adrenergic receptor expressed in human embryonic kidney (HEK293) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173165(CHEMBL194323 | N'-(4,5-Dihydro-oxazol-2-yl)-N-(3-m...)
Affinity DataKi:  5.30nMAssay Description:Binding affinity towards alpha-1A adrenergic receptor expressed in human embryonic kidney (HEK293) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173162(CHEMBL362954 | N'-(4,5-Dihydro-1H-imidazol-2-yl)-N...)
Affinity DataKi:  6.30nMAssay Description:Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137388(((R)-2-Methyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  7nMAssay Description:Inhibitory activity against recombinant human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173162(CHEMBL362954 | N'-(4,5-Dihydro-1H-imidazol-2-yl)-N...)
Affinity DataKi:  7.30nMAssay Description:Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137398(((R)-2-(4-Hydroxy-phenyl)-1-{3-phenyl-1-[(4-piperi...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137387(((R)-3-Phenyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137391(((R)-1-{3-Phenyl-1-[(4-piperidin-1-yl-phenylamino)...)
Affinity DataKi:  9nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50122028(3-Methoxy-N-[2-(4-p-tolyl-piperazin-1-yl)-ethyl]-b...)
Affinity DataKi:  9.21nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137393(CHEMBL353725 | {(S)-1-[(S)-1-Benzyl-2-(4-piperidin...)
Affinity DataKi:  10nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(RAT)
Universita` Degli Studi Di Bari A Moro

Curated by ChEMBL
LigandPNGBDBM50122044(CHEMBL345111 | N-{2-[4-(5-Chloro-pyridin-2-yl)-pip...)
Affinity DataKi:  11.3nMAssay Description:Displacement of [3H]MSP from rat dopamine D4 receptor expressed in HEK293 cells after 90 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137386(2-{(S)-3-Phenyl-1-[(4-piperidin-1-yl-phenylamino)-...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137390(((R)-3-Methylsulfanyl-1-{3-phenyl-1-[(4-piperidin-...)
Affinity DataKi:  12nMAssay Description:Inhibitory activity against recombinant human cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173164(3-[N'-(4,5-Dihydro-1H-imidazol-2-yl)-N-p-tolyl-hyd...)
Affinity DataKi:  13nMAssay Description:Binding affinity towards human alpha-2C adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137387(((R)-3-Phenyl-1-{3-phenyl-1-[(4-piperidin-1-yl-phe...)
Affinity DataKi:  14nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137395(CHEMBL170242 | {(S)-1-[(S)-1-Benzyl-2-(4-morpholin...)
Affinity DataKi:  15nMAssay Description:Inhibitory activity against recombinant human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173164(3-[N'-(4,5-Dihydro-1H-imidazol-2-yl)-N-p-tolyl-hyd...)
Affinity DataKi:  18nMAssay Description:Binding affinity towards human alpha-2B adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173162(CHEMBL362954 | N'-(4,5-Dihydro-1H-imidazol-2-yl)-N...)
Affinity DataKi:  18nMAssay Description:Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1D adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Affinity DataKi:  19nMAssay Description:Binding affinity towards human alpha-1D adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173162(CHEMBL362954 | N'-(4,5-Dihydro-1H-imidazol-2-yl)-N...)
Affinity DataKi:  20nMAssay Description:Binding affinity towards alpha-1A adrenergic receptor expressed in human embryonic kidney (HEK293) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50137397(CHEMBL341014 | [(S)-1-((S)-1-Benzyl-2-oxo-ethylcar...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against recombinant human cathepsin LMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173164(3-[N'-(4,5-Dihydro-1H-imidazol-2-yl)-N-p-tolyl-hyd...)
Affinity DataKi:  24nMAssay Description:Binding affinity towards human alpha-2A adrenergic receptor expressed in Chinese Hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Chungbuk National University

Curated by ChEMBL
LigandPNGBDBM50173164(3-[N'-(4,5-Dihydro-1H-imidazol-2-yl)-N-p-tolyl-hyd...)
Affinity DataKi:  27nMAssay Description:Binding affinity towards alpha-1A adrenergic receptor expressed in human embryonic kidney (HEK293) cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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