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Found 393 with Last Name = 'lockey' and Initial = 'pm'
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012544(CHEMBL3260768)
Affinity DataKi:  0.300nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113780((2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012543(CHEMBL3260767)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  0.820nMAssay Description:Binding affinity to glucocorticoid receptor in SW1353 cells by whole-cell binding assayMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human glucocorticoid receptor in SW1353 cells assessed as inhibition of dexamethasone-induced luciferase expression by MMTV5 r...More data for this Ligand-Target Pair
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012532(CHEMBL3260463)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012502(CHEMBL3260457)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012542(CHEMBL3260766)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221149(8a-(4-(pyridin-4-yl)benzyl)-2-(4-tert-butylphenyls...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012534(CHEMBL3260758)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012545(BGC-201531 | CHEMBL1628698)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012548(CHEMBL3260771)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012533(CHEMBL3260757)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221173((R)-8a-benzyl-2-(4-tert-butylphenylsulfonyl)-1,2,3...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113780((2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a...)
Affinity DataKi:  4nMAssay Description:Antagonist activity at human glucocorticoid receptor in SW1353 cells assessed as inhibition of dexamethasone-induced luciferase expression by MMTV5 r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221153((R)-8a-(4-methoxybenzyl)-2-(4-tert-butylphenylsulf...)
Affinity DataKi:  4nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216485(5-benzyl-6-(4-(3-chlorophenyl)piperidin-1-yl)pyrim...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012501(CHEMBL3260456)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012530(CHEMBL3260461)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221180(8a-(4-fluorobenzyl)-2-(4-tert-butylphenylsulfonyl)...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50113780((2R,4aS,10aR)-4a-benzyl-2-(prop-1-ynyl)-1,2,3,4,4a...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity to glucocorticoid receptor in SW1353 cells by whole-cell binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221170(8a-(4-methoxybenzyl)-2-(4-tert-butylphenylsulfonyl...)
Affinity DataKi:  6nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216493(5-benzyl-6-(3-phenylpiperidin-1-yl)pyrimidine-2,4(...)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012549(CHEMBL3260772)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216480(5-benzyl-6-(4-(2-methoxyphenyl)piperidin-1-yl)pyri...)
Affinity DataKi:  7.10nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216491(5-benzyl-6-(4-phenylpiperidin-1-yl)pyrimidine-2,4(...)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216488(5-(2-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)
Affinity DataKi:  8.70nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221156(8a-(4-(piperidin-1-yl)benzyl)-2-(4-tert-butylpheny...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221188(8a-(4-bromobenzyl)-2-(4-tert-butylphenylsulfonyl)-...)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216474(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216479(5-benzyl-6-(4-(3-methoxyphenyl)piperidin-1-yl)pyri...)
Affinity DataKi:  9.20nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221164(8a-(4-morpholinobenzyl)-2-(4-tert-butylphenylsulfo...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012531(CHEMBL3260462)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221157(CHEMBL247815 | N-(4-((2-(4-tert-butylphenylsulfony...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221175(2-[(4-tert-butylbenzene)sulfonyl]-8a-({4-[(dimethy...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012546(CHEMBL3260769)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012541(CHEMBL3260765)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216494(5-(3-bromobenzyl)-6-(4-phenylpiperidin-1-yl)pyrimi...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221158(8a-benzyl-2-(4-tert-butylphenylsulfonyl)-1,2,3,4,8...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50221177(8a-(4-(dimethylamino)benzyl)-2-(4-tert-butylphenyl...)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]dexamethasone from human glucocorticoid receptor expressed in recombinant baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012539(CHEMBL3260763)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216476(5-(3-chlorobenzyl)-6-(4-benzylpiperidin-1-yl)-3-me...)
Affinity DataKi:  16nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216482(5-benzyl-6-(4-benzylpiperidin-1-yl)pyrimidine-2,4(...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315314(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012511(CHEMBL3260459)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012486(CHEMBL3260443)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Corcept Therapeutics

Curated by ChEMBL
LigandPNGBDBM50216489(5-benzyl-3-methyl-6-(4-phenylpiperidin-1-yl)pyrimi...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]dexamethasone from human recombinant GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012535(CHEMBL3260759)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50012503(CHEMBL3260458)
Affinity DataKi:  22nMAssay Description:Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in cell membranes by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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