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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50012486
Substrate
n/a
Meas. Tech.
ChEMBL_1351394 (CHEMBL3266970)
Ki
20±n/a nM
Citation
 Sutton, J; Clark, DE; Higgs, C; de Groot, MJ; Harris, NV; Taylor, A; Lockey, PM; Maubach, K; Woodrooffe, A; Davis, RJ; Coleman, RA; Clark, KL From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg Med Chem Lett 24:2212-21 (2014) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50012486
Synonyms:
CHEMBL3260443
Type:
Small organic molecule
Emp. Form.:
C20H16F2O5
Mol. Mass.:
374.3348
SMILES:
Cc1oc(cc1COc1ccc(cc1)-c1ccc(OC(F)F)cc1)C(O)=O
Structure:
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