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Found 81 with Last Name = 'loughney' and Initial = 'da'
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50368147((+)-(3R,5S)-fluvastatin | (3R,5S)-fluvastatin | (3...)
Affinity DataIC50:  2.5nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0040More data for this Ligand-Target Pair
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042682(CHEMBL122674 | Sodium; 7-[7-biphenyl-4-ylmethyl-2-...)
Affinity DataIC50:  3nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0015-0.0049More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22302(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50:  6nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22304(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Affinity DataIC50:  8nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042665(CHEMBL332812 | Sodium; 7-[2-(4-fluoro-phenyl)-7-na...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0050-0.016More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042675(CHEMBL421436 | Sodium;2-{2-[2,6-dimethyl-8-(2-meth...)
Affinity DataIC50:  9.20nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0073-0.017More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22308(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50:  10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22303(N-{3-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]propyl}-...)
Affinity DataIC50:  10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22305(N-[2-(2-dibenzo[b,d]furan-2-yl-1H-indol-3-yl)ethyl...)
Affinity DataIC50:  10nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22299(4-pentyl-N-{2-[2-(4-propanoylphenyl)-1H-indol-3-yl...)
Affinity DataIC50:  11nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22300(4-pentyl-N-(2-{2-[4-(trifluoromethyl)phenyl]-1H-in...)
Affinity DataIC50:  11nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22312(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Affinity DataIC50:  11nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22314(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Affinity DataIC50:  12nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22306(4-pentyl-N-{2-[2-(quinolin-3-yl)-1H-indol-3-yl]eth...)
Affinity DataIC50:  13nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042681(CHEMBL123826 | Sodium; 7-[7-(4-tert-butyl-benzyl)-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0040-0.053More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22311(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Affinity DataIC50:  15nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22297(N-{2-[2-(3-methylphenyl)-1H-indol-3-yl]ethyl}-4-pe...)
Affinity DataIC50:  25nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22295(N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl}-4-p...)
Affinity DataIC50:  27nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042678(CHEMBL331900 | Sodium; 7-[2-(4-fluoro-phenyl)-7-na...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.021-0.036More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042673(CHEMBL124354 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(4...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.021-0.036More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042670(CHEMBL421080 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(4...)
Affinity DataIC50:  28nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.015-0.51More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22301(N-{2-[2-(2,5-dimethoxyphenyl)-1H-indol-3-yl]ethyl}...)
Affinity DataIC50:  28nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22309(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50:  30nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22298(N-{2-[2-(4-chlorophenyl)-1H-indol-3-yl]ethyl}-4-pe...)
Affinity DataIC50:  32nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042672(CHEMBL122815 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(3...)
Affinity DataIC50:  35nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.027-0.046More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22293(N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl}-4-p...)
Affinity DataIC50:  37nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042684(CHEMBL122605 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(4...)
Affinity DataIC50:  40nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.0040-0.053More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22313(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Affinity DataIC50:  42nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22286(N-[3-(1H-indol-3-yl)propyl]-4-pentylbenzene-1-sulf...)
Affinity DataIC50:  47nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22310(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50:  47nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22296(4-pentyl-N-[2-(2-phenyl-1H-indol-3-yl)ethyl]benzen...)
Affinity DataIC50:  62nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042674(CHEMBL331770 | Sodium; 7-[7-benzyl-2-(4-fluoro-phe...)
Affinity DataIC50:  68nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.047-0.098More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22317(4-({2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}s...)
Affinity DataIC50:  76nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042677(CHEMBL124769 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(3...)
Affinity DataIC50:  82nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.038-0.18More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22315(N-{2-[2-(1-benzofuran-2-yl)-1H-indol-3-yl]ethyl}-4...)
Affinity DataIC50:  89nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042671(CHEMBL332353 | Sodium; 7-[7-(2-chloro-benzyl)-2-(4...)
Affinity DataIC50:  95nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.026-0.34More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22292(4-butyl-N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]et...)
Affinity DataIC50:  110nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22291(N-{2-[2-(4-methoxyphenyl)-1H-indol-3-yl]ethyl}-4-m...)
Affinity DataIC50:  110nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22287(N-[4-(1H-indol-3-yl)butyl]-4-pentylbenzene-1-sulfo...)
Affinity DataIC50:  110nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042667(CHEMBL120102 | Sodium; 7-[7-(4-chloro-benzyl)-2-(4...)
Affinity DataIC50:  140nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.07-0.27More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22307(N-methyl indole sulfonamide, 39 | N-{2-[2-(1-benzo...)
Affinity DataIC50:  143nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042664(CHEMBL121014 | Sodium; 7-[2-(4-fluoro-phenyl)-7-(3...)
Affinity DataIC50:  160nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.12-0.21More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042676(CHEMBL122607 | Sodium; 7-[7-(4-fluoro-benzyl)-2-(4...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.16-0.24More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22288(methyl 3-{2-[(4-pentylbenzene)sulfonamido]ethyl}-1...)
Affinity DataIC50:  236nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22276(4-(4-ethylphenyl)-N-[2-(1H-indol-3-yl)ethyl]benzen...)
Affinity DataIC50:  260nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22280(4-(4-tert-butylphenyl)-N-[2-(1H-indol-3-yl)ethyl]b...)
Affinity DataIC50:  270nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22277(N-[2-(1H-indol-3-yl)ethyl]-4-[4-(propan-2-yl)pheny...)
Affinity DataIC50:  280nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50042683(CHEMBL332548 | Sodium; 7-[7-(3,4-dimethoxy-benzyl)...)
Affinity DataIC50:  320nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.17-0.61More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
R. W. Johnson Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM34168(LOVASTATIN | MLS000069585 | SMR000058779 | US91151...)
Affinity DataIC50:  400nMAssay Description:Inhibitory activity against partially purified rat liver HMG-CoA reductase in vitro; 0.23-0.71More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Oryctolagus cuniculus (rabbit))
Bristol-Myers Squibb

LigandPNGBDBM22272(N-[2-(1H-indol-3-yl)ethyl]-4-pentylbenzene-1-sulfo...)
Affinity DataIC50:  420nMAssay Description:The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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