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Target
Plasmepsin IX
Ligand
BDBM50595797
Substrate
n/a
Meas. Tech.
ChEMBL_2218028 (CHEMBL5131160)
IC50
1.4±n/a nM
Citation
 de Lera Ruiz, M; Favuzza, P; Guo, Z; Zhao, L; Hu, B; Lei, Z; Zhan, D; Murgolo, N; Boyce, CW; Vavrek, M; Thompson, J; Ngo, A; Jarman, KE; Robbins, J; Boddey, J; Sleebs, BE; Lowes, KN; Cowman, AF; Olsen, DB; McCauley, JA The Invention of WM382, a Highly Potent PMIX/X Dual Inhibitor toward the Treatment of Malaria. ACS Med Chem Lett 13:1745-1754 (2022) [PubMed] 
Target
Name:
Plasmepsin IX
Synonyms:
3.4.23.- | PLM9_PLAF7 | PMIX | PfPMIX | Plasmepsin 9
Type:
PROTEIN
Mol. Mass.:
74220.96
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_120775
Residue:
627
Sequence:
MFFINFKKIKKKQFPIYLTQHRIITVFLIFIYFINLKDCFHINNSRILSDVDKHRGLYYNIPKCNVCHKCSICTHENGEAQNVIPMVAIPSKRKHIQDINKEREENKYPLHIFEEKDIYNNKDNVVKKEDIYKLRKKKKQKKNCLNFLEKDTMFLSPSHDKETFHINHMNKIKDEKYKQEYEEEKEIYDNTNTSQEKNETNNEQNLNINLINNDKVTLPLQQLEDSQYVGYIQIGTPPQTIRPIFDTGSTNIWIVSTKCKDETCLKVHRYNHKLSSSFKYYEPHTNLDIMFGTGIIQGVIGVETFKIGPFEIKNQSFGLVKREKASDNKSNVFERINFEGIVGLAFPEMLSTGKSTLYENLMSSYKLQHNEFSIYIGKDSKYSALIFGGVDKNFFEGDIYMFPVVKEYYWEIHFDGLYIDHQKFCCGVNSIVYDLKKKDQENNKLFFTRKYFRKNKFKTHLRKYLLKKIKHQKKQKHSNHKKKKLNKKKNYLIFDSGTSFNSVPKDEIEYFFRVVPSKKCDDSNIDQVVSSYPNLTYVINKMPFTLTPSQYLVRKNDMCKPAFMEIEVSSEYGHAYILGNATFMRYYYTVYRRGNNNNSSYVGIAKAVHTEENEKYLSSLHNKINNL
  
Inhibitor
Name:
BDBM50595797
Synonyms:
CHEMBL5171401
Type:
Small organic molecule
Emp. Form.:
C29H36N4O4
Mol. Mass.:
504.6205
SMILES:
CCC1(CC)CC(=O)N([C@@H]2CCOc3ccc(cc23)C(=O)N[C@H]2CC(C)(C)Oc3ccccc23)C(=N)N1 |r|
Structure:
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