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Found 591 with Last Name = 'mattson' and Initial = 'mv'
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50000066((2-Azepan-1-yl-ethyl)-[2-(3,4-dichloro-phenyl)-eth...)
Affinity DataKi:  0.170nMAssay Description:Inhibition of [3H]-NANM binding to sigma receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041240((6S,11R)-3-Allyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  0.300nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50000069(CHEMBL20377 | [2-(3,4-Dichloro-phenyl)-ethyl]-meth...)
Affinity DataKi:  0.340nMAssay Description:Tested for its binding affinity towards sigma-1 site in rat brain, using [3H](+)-3-PPP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095694(3-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2...)
Affinity DataKi:  0.400nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095706(4-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2...)
Affinity DataKi:  0.400nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037492(CHEMBL113995 | [(S)-2-(2-{(S)-2-[(S)-2-Amino-3-(4-...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity against opioid receptor by displacing radioligand [3H]DAMGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095705(3-But-2-ynyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  0.5nMAssay Description:Ki value determined against Opioid receptor mu 1 using [3H]-DAMGO at the Kd concentration 0.57 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041240((6S,11R)-3-Allyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  0.900nMAssay Description:Ki value determined against Opioid receptor mu 1 using [3H]-DAMGO at the Kd concentration 0.57 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  1nMAssay Description:Binding affinity towards muscarinic m2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50095699(3-Hex-5-enyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  1.10nMAssay Description:Ki value determined against Sigma opioid receptor type 1 using [(+)-[3H]pentazocaine at the Kd concentration 2nM .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50381677(CHEMBL1256748 | U-69593)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against opioid receptor by displacing radioligand [3HlU69,593More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095703(3-But-3-enyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  1.30nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095707(3-But-3-ynyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  1.40nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037478((6S,11R)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Affinity DataKi:  1.5nMAssay Description:Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029792(5-(3-Hydroxy-phenyl)-8-[1-(3-iodo-phenyl)-meth-(E)...)
Affinity DataKi:  1.62nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029787(5-(3-Hydroxy-phenyl)-8-[1-(4-iodo-phenyl)-meth-(E)...)
Affinity DataKi:  1.71nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029786(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Affinity DataKi:  1.90nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50037489((6S,11S)-3-Heptyl-6,11-dimethyl-1,2,3,4,5,6-hexahy...)
Affinity DataKi:  1.90nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50039200((4-Phenyl-butyl)-(5-phenyl-pentyl)-amine | CHEMBL2...)
Affinity DataKi:  2nMAssay Description:Tested for its binding affinity towards sigma-1 site in rat brain, using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  2nMAssay Description:Binding affinity towards muscarinic m1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037478((6S,11R)-6,11-Dimethyl-3-propyl-1,2,3,4,5,6-hexahy...)
Affinity DataKi:  2nMAssay Description:Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50367061(NALORPHINE | NALORPHINE HYDROCHLORIDE)
Affinity DataKi:  2nMAssay Description:Compound administered subcutaneously was evaluated for inhibition constant measured as the displacement of [3H]DAGO from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095703(3-But-3-enyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  2.10nMAssay Description:Ki value determined against Opioid receptor mu 1 using [3H]-DAMGO at the Kd concentration 0.57 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
University Of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50095711(6,11-Dimethyl-3-pent-4-enyl-1,2,3,4,5,6-hexahydro-...)
Affinity DataKi:  2.10nMAssay Description:Ki value determined against Sigma opioid receptor type 1 using [(+)-[3H]pentazocaine at the Kd concentration 2nM .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029789(5-(3-Hydroxy-phenyl)-2-methyl-8-[1-naphthalen-2-yl...)
Affinity DataKi:  2.20nMAssay Description:Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50037476((6R,11S)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  2.30nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50037484((6S,11S)-6,11-Dimethyl-3-octyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  2.80nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50001683(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Affinity DataKi:  3nMAssay Description:Binding affinity against opioid receptor by displacing radioligand [3H]DPDPEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50029791(8-[1-(3-Chloro-phenyl)-meth-(E)-ylidene]-5-(3-hydr...)
Affinity DataKi:  3.10nMAssay Description:Ability to inhibit [3H]-(+)-pentazocine binding to guinea pig brain Sigma receptor type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037482((6S,11R)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  3.40nMAssay Description:Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50037480((6R,11S)-6,11-Dimethyl-3-pentyl-1,2,3,4,5,6-hexahy...)
Affinity DataKi:  3.80nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50001028((+)-PENTAZOCINE | (-)-pentazocine | (2R,6R,11R)-6,...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of [3H](+)-pentazocine binding to sigma receptor of guinea pig brain homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029786(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Affinity DataKi:  3.90nMAssay Description:Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029786(5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-...)
Affinity DataKi:  3.90nMAssay Description:Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095705(3-But-2-ynyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  3.90nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037469((6S,11R)-3,6,11-Trimethyl-1,2,3,4,5,6-hexahydro-2,...)
Affinity DataKi:  4.20nMAssay Description:Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095694(3-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2...)
Affinity DataKi:  4.20nMAssay Description:Ki value determined against Opioid receptor mu 1 using [3H]-DAMGO at the Kd concentration 0.57 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity against sigma receptor was determinedMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50407214(CHEMBL2008608)
Affinity DataKi:  4.5nMAssay Description:Inhibition of radioligand [3H]-DAMGO binding to rat brain mu receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095707(3-But-3-ynyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  4.60nMAssay Description:Ki value determined against Opioid receptor mu 1 using [3H]-DAMGO at the Kd concentration 0.57 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50037475((6S,11R)-3-Hexyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  4.70nMAssay Description:Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037482((6S,11R)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  4.90nMAssay Description:Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041240((6S,11R)-3-Allyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  5.5nMAssay Description:Ki value determined against Opioid receptor delta 1 using [3H]-DPDPE at the Kd concentration 2.1 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095706(4-(8-Hydroxy-6,11-dimethyl-1,2,5,6-tetrahydro-4H-2...)
Affinity DataKi:  5.80nMAssay Description:Ki value determined against Opioid receptor mu 1 using [3H]-DAMGO at the Kd concentration 0.57 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095708(3-Hex-5-enyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2...)
Affinity DataKi:  5.80nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50095712(6,11-Dimethyl-3-pent-4-enyl-1,2,3,4,5,6-hexahydro-...)
Affinity DataKi:  5.90nMAssay Description:Ki value determined against Opioid receptor kappa 1 using [3H]U69, 593 at the Kd concentration 0.95 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50037472((6R,11S)-3-Butyl-6,11-dimethyl-1,2,3,4,5,6-hexahyd...)
Affinity DataKi:  6nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2C(Rattus norvegicus (Rat))
National Institute Of Diabetes

Curated by ChEMBL
LigandPNGBDBM50015743(Acetic acid 3-[1-(3,6-dihydro-2H-pyridin-1-yl)-cyc...)
Affinity DataKi:  6nMAssay Description:Ability to displace [3H]- TCP from PCP receptor in tissue homogenate preparation of fresh whole rat brain minus cerebellum.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029788(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Affinity DataKi:  6.10nMAssay Description:Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50029788(8-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-5-(3-...)
Affinity DataKi:  6.10nMAssay Description:Ability to inhibit [3H]-DAMGO binding to rat brain Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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