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Target
Mu-type opioid receptor
Ligand
BDBM50029786
Substrate
n/a
Meas. Tech.
ChEMBL_148838 (CHEMBL753956)
Ki
3.90±n/a nM
Citation
 Bertha, CM; Vilner, BJ; Mattson, MV; Bowen, WD; Becketts, K; Xu, H; Rothman, RB; Flippen-Anderson, JL; Rice, KC (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype. J Med Chem 38:4776-85 (1996) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50029786
Synonyms:
5-(3-Hydroxy-phenyl)-8-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-2-methyl-2-aza-bicyclo[3.3.1]nonan-7-one | CHEMBL143800
Type:
Small organic molecule
Emp. Form.:
C23H25NO3
Mol. Mass.:
363.4495
SMILES:
COc1ccc(C=C2C3CC(CCN3C)(CC2=O)c2cccc(O)c2)cc1 |w:6.5|
Structure:
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