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Found 791 with Last Name = 'muraglia' and Initial = 'e'
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110121(3-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110117(4-(2-Acetylamino-3-carboxy-propionylamino)-4-(1-{3...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Irbm, Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50110125(2-[2-(2-{2-[2-(2-Acetylamino-3-carboxy-propionylam...)
Affinity DataKi:  40nMAssay Description:Inhibitory activity against hepatitis C virus (HCV) NS3/NS4A serine proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309361(2-(4-(5-((6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309375(6,7-dichloro-4-(4-fluoro-3-(4-pivaloylpiperazine-1...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309393(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-7-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309350(4-(3-(4-(azetidin-1-yl)piperidine-1-carbonyl)-4-fl...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309357(6,7-dichloro-4-(4-fluoro-3-(4-(quinazolin-2-yl)pip...)
Affinity DataIC50:  1nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309241((R)-6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbon...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309356(6,7-dichloro-4-(4-fluoro-3-(4-(quinazolin-4-yl)pip...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.40nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Irbm (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  1.60nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309391(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-7,...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309394(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-7-...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309358(6,7-dichloro-4-(4-fluoro-3-(4-(isoquinolin-3-yl)pi...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309249(6-(3-(4-(2-allylpyrrolidine-2-carbonyl)piperazine-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309395(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pyr...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309229(6-(3-(4-(2-(dimethylamino)-2-methylpropanoyl)piper...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM25330(2-[4-(dimethylamino)oxan-4-yl]-N-[(4-fluorophenyl)...)
Affinity DataIC50:  2nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309368(2-(4-(5-((6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309376(6,7-dichloro-4-(4-fluoro-3-(4-isobutyrylpiperazine...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309222(6,7-dichloro-4-(4-fluoro-3-(4-(2-methyl-2-(methyla...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309387(6,7-dichloro-4-(4-fluoro-3-(piperazine-1-carbonyl)...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309354(6,7-dichloro-4-(4-fluoro-3-(4-(methylamino)piperid...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309234(6-(3-(4-(1-(cyclopropylmethylamino)cyclopentanecar...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309373(6,7-dichloro-4-(4-fluoro-3-(4-picolinoylpiperazine...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309369(4-(5-((6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309367(6,7-dichloro-4-(3-(4-(2-(dimethylamino)acetyl)pipe...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309221(6,7-dichloro-4-(4-fluoro-3-(1,8-diazaspiro[4.5]dec...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309253((R)-6-(4-fluoro-3-(4-(2-(4-fluorobenzyl)pyrrolidin...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309221(6,7-dichloro-4-(4-fluoro-3-(1,8-diazaspiro[4.5]dec...)
Affinity DataIC50:  2.5nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309392(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)-6,...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309223(6-(4-fluoro-3-(1,8-diazaspiro[4.5]decane-8-carbony...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309353(6,7-dichloro-4-(3-(4-(dimethylamino)piperidine-1-c...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309235(6-(4-fluoro-3-(4-(1-(pyrrolidin-1-yl)cyclopentanec...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309232(6-(4-fluoro-3-(4-(1-(methylamino)cyclopentanecarbo...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309243((R)-6-(4-fluoro-3-(4-(pyrrolidine-2-carbonyl)piper...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309244(6-(4-fluoro-3-(4-(2-methyltetrahydrofuran-2-carbon...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309364(6,7-dichloro-4-(4-fluoro-3-(4-(pyridin-2-yl)pipera...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PARP1 by topcount microplate scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309239(6-(4-fluoro-3-(4-(2-methylpyrrolidine-2-carbonyl)p...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM25329(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-[2...)
Affinity DataIC50:  3nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183190(2-(1-(2-bromo-4-methylphenyl)-1H-tetrazol-5-ylthio...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183217(CHEMBL206522 | N-(2-chloro-4-sulfamoyl-phenyl)-2-[...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183200(3-chloro-4-(2-(1-mesityl-1H-tetrazol-5-ylthio)acet...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183199(2-(1-(3-chloro-2-methylphenyl)-1H-tetrazol-5-ylthi...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus 1)
Mrl Rome

Curated by ChEMBL
LigandPNGBDBM50183196(2-(1-mesityl-1H-tetrazol-5-ylthio)-N-(2-nitropheny...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HIV1 wild type Reverse TranscriptaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
Merck Research Laboratories

LigandPNGBDBM22682(Bicyclic pyrimidinone, 15b | N-[(4-fluorophenyl)me...)
Affinity DataIC50:  3nMpH: 7.8 T: 2°CAssay Description:The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309242((S)-6-(4-fluoro-3-(4-(pyrrolidine-2-carbonyl)piper...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50309247((R)-6-(4-fluoro-3-(4-(2-methylazetidine-2-carbonyl...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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