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Found 102 with Last Name = 'nakao' and Initial = 'y'
TargetProthrombin(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50269601(CHEMBL507449 | cyclotheonamide E)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50259920(CHEMBL448342 | Cyclotheonamide E3)
Affinity DataIC50:  9.5nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50259922(CHEMBL505589 | Cyclotheonamide E2)
Affinity DataIC50:  13nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50157741(CHEMBL374508 | E-64 | E64)
Affinity DataIC50:  13.7nMAssay Description:Inhibitory activity against Cathepsin B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50213272(CHEBI:6426 | Leupeptin)
Affinity DataIC50:  21.6nMAssay Description:Inhibitory activity against Cathepsin B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50118723(CHEMBL342672 | CYCLOTHEONAMIDE A | N-[14-Benzyl-18...)
Affinity DataIC50:  23nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  36.6nMAssay Description:Inhibition of human HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50217331(TOKARAMIDE A)
Affinity DataIC50:  60.9nMAssay Description:Inhibitory activity against Cathepsin B was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  62.9nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  83.3nMAssay Description:Inhibition of human HDAC6 expressed in 293T cellsMore data for this Ligand-Target Pair
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50478556(CORTICATIC ACID A)
Affinity DataIC50:  344nMAssay Description:Inhibition of alpha-glucosidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSialidase(Clostridium perfringens)
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50478507(Nobiloside)
Affinity DataIC50:  488nMAssay Description:Inhibition of Clostridium perfringens neuraminidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50478555(Callyspongynic Acid)
Affinity DataIC50:  531nMAssay Description:Inhibition of alpha-glucosidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  560nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  924nMAssay Description:Inhibition of MMP12More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  1.09E+3nMAssay Description:Inhibition of MMP8More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50377384(AZUMAMIDE C)
Affinity DataIC50:  1.17E+3nMAssay Description:Inhibition of human HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50372469(AZUMAMIDE E)
Affinity DataIC50:  1.22E+3nMAssay Description:Inhibition of human HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  1.31E+3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50377383(AZUMAMIDE B)
Affinity DataIC50:  1.83E+3nMAssay Description:Inhibition of human HDAC1 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  2.21E+3nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50372469(AZUMAMIDE E)
Affinity DataIC50:  2.28E+3nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393111(CHEMBL2153261)
Affinity DataIC50:  2.63E+3nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50377384(AZUMAMIDE C)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  3.36E+3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Waseda University

Curated by ChEMBL
LigandPNGBDBM50377383(AZUMAMIDE B)
Affinity DataIC50:  3.66E+3nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  4.76E+3nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  5.60E+3nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50484453(Shishicrellastatin A)
Affinity DataIC50:  6.79E+3nMAssay Description:Inhibition of bovine cathepsin B after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin B(Bos taurus (bovine))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50484452(Shishicrellastatin B)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibition of bovine cathepsin B after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50393108(CHEMBL2153266)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215927(4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amin...)
Affinity DataIC50:  8.03E+3nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal alpha-glucosidase(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50478557(Petrosynol)
Affinity DataIC50:  8.82E+3nMAssay Description:Inhibition of alpha-glucosidaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human recombinant PIM1 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Sus scrofa)
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393109(CHEMBL2153264)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of porcine brain CK1 using RRKHAAIGpSAYSITA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393113(CHEMBL2153265)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50393112(CHEMBL2153263)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393112(CHEMBL2153263)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393115(CHEMBL575945)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393111(CHEMBL2153261)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of human recombinant MMP2 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393110(CHEMBL2153260)
Affinity DataIC50:  1.59E+4nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50003299(CHEMBL469919)
Affinity DataIC50:  1.96E+4nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50478551(CHEMBL462863 | Sodium 1-(12-Hydroxy)Octadecanyl Su...)
Affinity DataIC50:  2.31E+4nMAssay Description:Inhibition of recombinant MMP2More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50478536(Halistanol Sulfate)
Affinity DataIC50:  2.51E+4nMAssay Description:Inhibition of truncated recombinant MT1-MMP expressed in Escherichia coli JM109 after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393112(CHEMBL2153263)
Affinity DataIC50:  2.95E+4nMAssay Description:Inhibition of MMP14 using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg- NH2 as substrate preincubated for 10 mins measured after 3 hrs by fluorescence ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50215926(4-(4,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]py...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of rat recombinant GST-fused DYRK1A expressed in Escherichia coli using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50478535(CALLYSPONGINOL SULFATE A | CHEBI:65567)
Affinity DataIC50:  3.12E+4nMAssay Description:Inhibition of truncated recombinant MT1-MMP expressed in Escherichia coli JM109 after 1 hr by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Macquarie University

Curated by ChEMBL
LigandPNGBDBM50393110(CHEMBL2153260)
Affinity DataIC50:  3.40E+4nMAssay Description:Inhibition of human recombinant CDK5/p25 using [gamma-32P] ATP after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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