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Found 245 with Last Name = 'natarajan' and Initial = 'a'
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM81441(CDK Inhibitor, 14)
Affinity DataKi:  0.400nMAssay Description:Inhibition of recombinant human His-tagged CDK9/cyclin T1 expressed in baculovirus infected sf9 cells using (biotinyl-Ahx-(Tyr-Ser-ProThr-Ser-Pro-Ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4 (4 to 303 residues)/cyclin D1 (4 to 295 residues) expressed in sf9 cells using C-terminal ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM81441(CDK Inhibitor, 14)
Affinity DataKi:  2.30nMAssay Description:Inhibition of CDK7 (unknown origin) using (biotinyl-Ahx-(Tyr-Ser-ProThr-Ser-Pro-Ser)4-NH2 as substrate after 45 mins by [gamma-32P]ATP based microbet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  4nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin) using (biotinyl-Ahx-(Tyr-Ser-ProThr-Ser-Pro-Ser)4-NH2 as substrate after 45 mins by [gamma-32P]ATP base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataKi:  10nMAssay Description:Inhibition of recombinant full length human N-terminal GST-tagged CDK6 (1 to 326 residues)/cyclin D1 (4 to 295 residues) expressed in sf9 cells using...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193090(CHEMBL3895785)
Affinity DataKi:  17nMAssay Description:Inhibition of human CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi:  18nMAssay Description:Inhibition of recombinant human full length N-terminal His6-tagged CDK5/N-terminal GST-tagged p25 expressed in baculovirus infected Sf21 insect cells...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380359(CHEMBL2017822)
Affinity DataKi:  40nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi:  44nMAssay Description:Inhibition of human full length C-terminal His6-tagged CDK2/N-terminal GST-tagged cyclin A expressed in baculovirus infected Sf21 insect cells using ...More data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataKi:  57nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi:  67nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged CDK4/cyclin D1 expressed in baculovirus infected sf cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380358(CHEMBL2017821)
Affinity DataKi:  80nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380353(CHEMBL2017816)
Affinity DataKi:  100nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi: <100nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK9/cyclin T1 expressed in baculovirus infected Sf21 insect cells using PDKtide a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380352(CHEMBL2017815)
Affinity DataKi:  130nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM81441(CDK Inhibitor, 14)
Affinity DataKi:  149nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi:  190nMAssay Description:Inhibition of human full length C-terminal His6-tagged CDK1/N-terminal GST-tagged cyclin B expressed in baculovirus infected Sf21 insect cells using ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345641((S)-2-((S)-2-((S)-1-((S)-2-acetamido-3-(phosphonoo...)
Affinity DataKi:  200nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345640((S)-2-((2S,3R)-2-((S)-1-((S)-2-acetamido-3-(phosph...)
Affinity DataKi:  270nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380354(CHEMBL2017817)
Affinity DataKi:  500nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataKi:  504nMAssay Description:Inhibition of human CDK2/cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi:  510nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK2/N-terminal GST-tagged cyclin E expressed in baculovirus infected Sf21 insect ...More data for this Ligand-Target Pair
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380351(CHEMBL2017814)
Affinity DataKi:  540nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193090(CHEMBL3895785)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity to full length human CDK2 (1 to 298 residues) expressed in bacterial expression system by KINOMEscan competition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 3(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193090(CHEMBL3895785)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of CDK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193090(CHEMBL3895785)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of CDK5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193090(CHEMBL3895785)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193090(CHEMBL3895785)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380349(CHEMBL2017812)
Affinity DataKi:  1.24E+3nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataKi:  1.63E+3nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345623((S)-2-acetamido-3-((S)-2-((2S,3R)-1-((S)-1-amino-1...)
Affinity DataKi:  1.85E+3nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50345629((S)-2-acetamido-3-((S)-2-((S)-1-((S)-1-amino-1-oxo...)
Affinity DataKi:  1.96E+3nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50113281(AT-7519)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus infected Sf21 in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50110183(Abemaciclib | LY-2835219 | US10626107, Example LY2...)
Affinity DataKi:  3.91E+3nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged CDK7/cyclin H/N-terminal GST-tagged MAT1 expressed in baculovirus infected Sf21 in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380357(CHEMBL2017820)
Affinity DataKi:  4.04E+3nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM8037(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 8 | 4-...)
Affinity DataKi:  6.50E+3nMAssay Description:Inhibition of recombinant human His6-tagged CDK2/cyclin E expressed in baculovirus infected sf9 cells using histone H1 susbtrate in presence of [gamm...More data for this Ligand-Target Pair
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380355(CHEMBL2017818)
Affinity DataKi:  1.21E+4nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380356(CHEMBL2017819)
Affinity DataKi:  1.57E+4nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50380350(CHEMBL2017813)
Affinity DataKi:  1.94E+4nMAssay Description:Inhibition of BRCT domain of His-tagged BRCA1 after 1 min by competitive fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50221433(1-(9,10,10-trioxo-9,10-dihydro-10lambda*6*-thioxan...)
Affinity DataKi:  3.00E+4nMAssay Description:Inhibition of BRCA1 assessed as BRCT-BACH1 interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50221434(3-(4-benzyl-piperidin-1-yl)-10,10-dioxo-10H-10lamb...)
Affinity DataKi:  3.80E+4nMAssay Description:Inhibition of BRCA1 assessed as BRCT-BACH1 interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreast cancer type 1 susceptibility protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50221432(3-(4-methyl-piperidin-1-yl)-10,10-dioxo-10H-10lamb...)
Affinity DataKi:  3.90E+4nMAssay Description:Inhibition of BRCA1 assessed as BRCT-BACH1 interactionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Eppley Institute For Research In Cancer And Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193087(CHEMBL3897452)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK4/cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK9/cyclin T1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193103(CHEMBL3957795)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant full length His-tagged CDK9/cyclin T1 expressed in insect cells using biotin-Ttds-YISPLKSPYKISEG as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50193087(CHEMBL3897452)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK1/cyclin B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50139171(Dinaciclib | MK-7965 | SCH-727965 | US11643396, Ex...)
Affinity DataIC50:  1nMAssay Description:Inhibition of recombinant CDK2/cyclin A (unknown origin) expressed in baculovirus infected Sf9 insect cells using biotinylated histone H1 as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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