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Found 178 with Last Name = 'ohashi' and Initial = 'n'
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105033(CHEMBL112531 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataKi:  0.00420nMAssay Description:Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369953(CHEMBL1627022)
Affinity DataKi:  0.0150nMAssay Description:Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369953(CHEMBL1627022)
Affinity DataKi:  41nMAssay Description:Ability to inhibit [125I]-ET-1 binding to human cloned ETB receptors expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105000(CHEMBL175616 | sodium salt of 4-tert-Butyl-N-[6-(2...)
Affinity DataKi:  81nMAssay Description:Ability to inhibit [125I]ET1 binding to human cloned endothelin A receptor expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105033(CHEMBL112531 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataKi:  130nMAssay Description:Ability to inhibit [125I]-ET-1 binding to human cloned ETB receptors expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105000(CHEMBL175616 | sodium salt of 4-tert-Butyl-N-[6-(2...)
Affinity DataKi:  140nMAssay Description:Ability to inhibit [125I]-ET-1 binding to human cloned ETB receptors expressed on CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105055(4-tert-Butyl-N-{6-[2-(5-hydroxymethyl-pyrimidin-2-...)
Affinity DataIC50:  0.00260nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105051(CHEMBL112624 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.00620nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369954(CHEMBL1627023)
Affinity DataIC50:  0.0340nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105033(CHEMBL112531 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0390nMAssay Description:Ability to inhibit specific binding of [125I]- -ET-1 to rat A 10 cells which express endothelin A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105054(4-tert-Butyl-N-{5-(4-hydroxymethyl-phenyl)-6-[2-(5...)
Affinity DataIC50:  0.0400nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105057(CHEMBL324184 | N-[6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  0.0400nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(RAT)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369953(CHEMBL1627022)
Affinity DataIC50:  0.330nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105059(2-(4-{6-[2-(5-Bromo-pyrimidin-2-yloxy)-ethoxy]-5-p...)
Affinity DataIC50:  1.40nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataIC50:  3.5nMAssay Description:Binding affinity to HIV1 cYTA48P envelope glycoprotein gp120 infected in human TZM-b1 cells assessed as induction of conformational changes measured ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175766(1-(1-butyl-4-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1...)
Affinity DataIC50:  5.40nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105000(CHEMBL175616 | sodium salt of 4-tert-Butyl-N-[6-(2...)
Affinity DataIC50:  7.5nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369953(CHEMBL1627022)
Affinity DataIC50:  8.30nMAssay Description:Ability to inhibit specific binding of [125I]- -ET-1 to human GH cells which express endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175771(1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Affinity DataIC50:  8.30nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482699(CHEMBL1241174)
Affinity DataIC50:  10nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105052(2-{2-[6-(4-tert-Butyl-benzenesulfonylamino)-5-p-to...)
Affinity DataIC50: >10nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin-1 receptor(Sus scrofa)
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105053(4-{4-(4-tert-Butyl-benzenesulfonylamino)-6-[2-(5-m...)
Affinity DataIC50: >10nMAssay Description:Ability to inhibit [125I]ET1 binding to endothelin A receptor in porcine aortic membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175772(1-(1-butyl-4-(3-methoxyphenyl)-2-oxo-1,2-dihydro-1...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175767(1-(3-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50568672(CHEMBL4863234)
Affinity DataIC50:  17nMAssay Description:Inhibition of HIV1 KP-5mvcR gp120 interaction with CD4 in human TZM-bl cells assessed as decrease in viral entry by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175765(1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Affinity DataIC50:  21nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50369954(CHEMBL1627023)
Affinity DataIC50:  31nMAssay Description:Ability to inhibit specific binding of [125I]- -ET-1 to human GH cells which express endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482700(CHEMBL1241178)
Affinity DataIC50:  31nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Tanabe Seiyaku

Curated by ChEMBL
LigandPNGBDBM50105033(CHEMBL112531 | N-{6-[2-(5-Bromo-pyrimidin-2-yloxy)...)
Affinity DataIC50:  38nMAssay Description:Ability to inhibit specific binding of [125I]- -ET-1 to human GH cells which express endothelin B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482700(CHEMBL1241178)
Affinity DataIC50:  40nMAssay Description:Inhibition of HIV1 integrase 3'-processing activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482160(CHEMBL1082257)
Affinity DataIC50:  40nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelin-converting enzyme 1(Rattus norvegicus (Rat))
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50112397(CHEMBL22323 | Sodium;4-chloro-N-{[(4-cyano-3-methy...)
Affinity DataIC50:  42nMAssay Description:Tested in vitro for inhibition of Endothelin-converting enzyme (ECE) of rat lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175775(1-(3-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Affinity DataIC50:  43nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEnvelope glycoprotein gp160(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50568670(CHEMBL4849790)
Affinity DataIC50:  46nMAssay Description:Inhibition of HIV1 KP-5mvcR gp120 interaction with CD4 in human TZM-bl cells assessed as decrease in viral entry by MTT assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482714(CHEMBL1241175)
Affinity DataIC50:  47nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482699(CHEMBL1241174)
Affinity DataIC50:  50nMAssay Description:Inhibition of HIV1 integrase 3'-processing activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482698(CHEMBL1241173)
Affinity DataIC50:  50nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482710(CHEMBL1241189)
Affinity DataIC50:  50nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482701(CHEMBL1241179)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482704(CHEMBL1241184)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482161(CHEMBL1082256)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482720(CHEMBL1241183)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482709(CHEMBL1241187)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482703(CHEMBL1241182)
Affinity DataIC50:  60nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSterol O-acyltransferase 1(Rattus norvegicus)
Sumitomo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50175773(1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)
Affinity DataIC50:  61nMAssay Description:Inhibitory activity against ACAT in rat macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482719(CHEMBL1241176)
Affinity DataIC50:  65nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482713(CHEMBL1241172)
Affinity DataIC50:  70nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482712(CHEMBL1241169)
Affinity DataIC50:  70nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482716(CHEMBL1240540)
Affinity DataIC50:  70nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Tokyo Medical And Dental University

Curated by ChEMBL
LigandPNGBDBM50482717(CHEMBL1241180)
Affinity DataIC50:  80nMAssay Description:Inhibition of HIV1 integrase strand transfer activity expressed in Escherichia coli after 60 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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