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Found 109 with Last Name = 'osawa' and Initial = 't'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3032(CHEMBL1204168 | CHEMBL29197 | N-(3-bromophenyl)-6,...)
Affinity DataIC50:  4nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184863(CHEMBL202919 | N-(2-Chlorobenzoyl)-N'-{4-[(6,7-dim...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184860(CHEMBL380703 | Phenyl N-{4-[(6,7-Dimethoxy-4-quino...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184858(CHEMBL425935 | N-(2-Cyclohexyl)ethyl-N'-{4-[(6,7-d...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184864(CHEMBL203279 | N-{4-[(6,7-Dimethoxy-4-quinazolinyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cell by transactivation enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184868(CHEMBL378489 | N-Benzoyl-N'-{4-[(6,7-dimethoxy-4-q...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184856(CHEMBL204225 | N-(2-Cyclohexyl)ethyl-N'-{4-[(6,7-d...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184870(CHEMBL205953 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184859(CHEMBL204120 | N-Cyclohexylcarbonyl-N'-{4-[(6,7-di...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184867(2-Cyclohexylethyl N-{4-[(6,7-Dimethoxy-4-quinolyl)...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184860(CHEMBL380703 | Phenyl N-{4-[(6,7-Dimethoxy-4-quino...)
Affinity DataIC50:  19nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184870(CHEMBL205953 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  22nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141817(CHEMBL171509 | [1-(2-{4-[4-(4-tert-Butyl-phenylami...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  27nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184869(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)
Affinity DataIC50:  28nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290834(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Platelet-derived growth factor receptor beta (PDGF beta-R)More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184866(CHEMBL382399 | N-Cyclohexylmethyl-N'-{4-[(6,7-dime...)
Affinity DataIC50:  37nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184865(1-cyclohexyl-3-(4-(6,7-dimethoxyquinolin-4-yloxy)p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141829((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184862(CHEMBL204409 | N-Benzyl-N'-{4-[(6,7-dimethoxy-4-qu...)
Affinity DataIC50:  46nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141822((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  54nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141819((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  63nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184865(1-cyclohexyl-3-(4-(6,7-dimethoxyquinolin-4-yloxy)p...)
Affinity DataIC50:  69nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141812(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-2-fluoro-phe...)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mus musculus (mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50290834(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Affinity DataIC50:  70nMAssay Description:Inhibition of platelet-derived growth factor receptor (PDGF-R) in human aortic smooth muscle cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290838(4-(3-Bromo-phenoxy)-6,7-dimethoxy-quinazoline | CH...)
Affinity DataIC50:  70nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141823(2-[(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-...)
Affinity DataIC50:  71nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141813(1-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-meth...)
Affinity DataIC50:  71nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184867(2-Cyclohexylethyl N-{4-[(6,7-Dimethoxy-4-quinolyl)...)
Affinity DataIC50:  80nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50:  83nMAssay Description:Inhibition of vascular endothelial growth factor receptor 2 autophosphorylation in intact cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50:  88nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  96nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141810((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141809(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-m...)
Affinity DataIC50:  100nMAssay Description:Inhibition of c-Kit autophosphorylation in intact cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM50290834(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Affinity DataIC50:  130nMAssay Description:Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141832((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290834(4-(3,4-Dimethoxy-phenoxy)-6,7-dimethoxy-quinoline ...)
Affinity DataIC50:  150nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R) in A431 cells.More data for this Ligand-Target Pair
In DepthDetails Article
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184866(CHEMBL382399 | N-Cyclohexylmethyl-N'-{4-[(6,7-dime...)
Affinity DataIC50:  153nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141821((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  190nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141824((4-tert-Butyl-phenyl)-{4-[6-methoxy-7-(2-morpholin...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141816(1-{4-[4-(4-tert-Butyl-phenylamino)-phenoxy]-6-meth...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141814(CHEMBL276125 | [4-(6,7-Dimethoxy-quinolin-4-yloxy)...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184869(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)
Affinity DataIC50:  202nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM13530(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Affinity DataIC50:  219nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184859(CHEMBL204120 | N-Cyclohexylcarbonyl-N'-{4-[(6,7-di...)
Affinity DataIC50:  233nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)
Affinity DataIC50:  234nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cell by transactivation enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141811(2-(2-{4-[4-(4-tert-Butyl-phenylamino)-3-fluoro-phe...)
Affinity DataIC50:  260nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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