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Found 999 with Last Name = 'ouyang' and Initial = 'l'
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.0450nMAssay Description:Inhibition of p53 protein binding to MDM2 in human SJSA1 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.0900nMAssay Description:Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.130nMAssay Description:Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 6(Homo sapiens (Human))TBA
LigandPNGBDBM370121(6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcy...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity against CCK2 receptor estimated from single shifts of pentagastrin concentration-effect curves in the isolated rat stomachMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513204(CHEMBL4537250)
Affinity DataKi:  0.440nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513202(CHEMBL4463050)
Affinity DataKi:  0.600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513209(CHEMBL4440151)
Affinity DataKi:  0.880nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))TBA
LigandPNGBDBM50088301((E)-N,N-dimethyl-N-(4-(2-p-tolyl-6,7-dihydro-5H-be...)
Affinity DataKi:  1.10nMAssay Description:Antagonist at CCR5 (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM24466(1-(2-hydroxy-2-methylpropyl)-N-{5-[(7-methoxyquino...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513206(CHEMBL4546186)
Affinity DataKi:  1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513205(CHEMBL4437666)
Affinity DataKi:  1.20nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50593636(CHEMBL5192732)
Affinity DataKi:  1.30nMAssay Description:Binding affinity to BRD4-BD2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50502237(CHEMBL4470451)
Affinity DataKi:  1.60nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  1.60nMAssay Description:pA2 for NK2 receptor of rabbit pulmonary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50609374(CHEMBL5274383)
Affinity DataKi:  2.40nMAssay Description:Inhibition of mushroom tyrosinase using L-dopa as substrate assessed as inhibition constant incubated for 30 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))TBA
LigandPNGBDBM209932(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-...)
Affinity DataKi:  2.90nMAssay Description:Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50446130(AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucap...)
Affinity DataKi:  2.90nMAssay Description:Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM190196(EPZ008277 | US9175331, 25)
Affinity DataKi:  3nMAssay Description:Binding affinity to EZH2 mutant (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM190196(EPZ008277 | US9175331, 25)
Affinity DataKi:  3nMAssay Description:Binding affinity to wild-type EZH2 (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50306682((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Affinity DataKi:  4nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610781(CHEMBL5277261)
Affinity DataKi:  4nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as a substrate assessed as inhibition constant incubated for 5 mins by microplate reader analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataKi:  4.40nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant preincubated for 15 mins followed by substrate addition m...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))TBA
LigandPNGBDBM209932(2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-...)
Affinity DataKi:  5.20nMAssay Description:Antagonist potency against histamine H3 receptor in an electrically stimulated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  8.5nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50300119((2'R,3S,4'R,5'R)-6-chloro-4'-(3-chlorophenyl)-N-((...)
Affinity DataKi:  13nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610790(CHEMBL5287587)
Affinity DataKi:  76nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as inhibition constant preincubated with compound for 15 mins by microplate read...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50593636(CHEMBL5192732)
Affinity DataKi:  79nMAssay Description:Binding affinity to BRD4-BD1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50420273(CHEMBL2089208)
Affinity DataKi:  89nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50420268(CHEMBL2089203)
Affinity DataKi:  91nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50339398((+)-R-3-(4-Chlorophenyl)-3-(1-hydroxymethylcyclopr...)
Affinity DataKi:  170nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146168(ARQ-197 | Tivantinib)
Affinity DataKi:  355nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513207(CHEMBL4566706)
Affinity DataKi:  400nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM439497(US10633379, Example 35 | US10633379, Example 82)
Affinity DataKi:  520nMAssay Description:pA2 for NK2 receptor of rabbit pulmonary arteryMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50513201(CHEMBL4447592)
Affinity DataKi:  600nMAssay Description:Inhibition of p53 protein binding to MDM2 (unknown origin) by western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50148573((E,E)-1-piperoylpiperidine | 1-[(2E,4E)-5-(1,3-ben...)
Affinity DataKi:  710nMAssay Description:Binding affinity to N-terminal 6His-tagged recombinant human DHODH expressed in Escherichia coli strain BL21 (DE3) by isothermal titration calorimetr...More data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Sichuan University

Curated by ChEMBL
LigandPNGBDBM31196(spiro-oxindole, 1)
Affinity DataKi:  8.50E+3nMAssay Description:Inhibition of wild type p53 protein binding to MDM2 in human HCT116 cells by immunoblot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM110191(3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)propenone...)
Affinity DataIC50:  0.0130nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as diphenolase activity incubated for 20 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50021574(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Affinity DataIC50:  0.0350nMAssay Description:Inhibition of human VEGFR-2 using poly(Glu, Tyr) as substrate by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM110192(3-(2,4-Dihydroxyphenyl)-1-(furan-2-yl)propenone (1...)
Affinity DataIC50:  0.0433nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate assessed as diphenolase activityMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50356191(CHEMBL193804)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of mushroom tyrosinase using L-tyrosine as substrate assessed as monophenolase activity preincubated for 20 mins followed by substrate add...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610779(CHEMBL4475728)
Affinity DataIC50:  0.0680nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as a substrate by UV-2450 spectrophotometeric assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))TBA
LigandPNGBDBM36609(Rapamycin C-7, analog 4 | SIROLIMUS | US11603377, ...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of human mTORMore data for this Ligand-Target Pair
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50276368(CHEMBL4128371)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610793(CHEMBL5286240)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610794(CHEMBL5286802)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610795(CHEMBL5289108)
Affinity DataIC50: <0.100nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50146167(Capmatinib | INC-280 | INCB-28060 | NVP-INC280 | U...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of c-Met (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))TBA
LigandPNGBDBM50610775(CHEMBL5277673)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 20 mins by microti...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
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