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Found 330 with Last Name = 'pazhanisamy' and Initial = 's'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM9235((2S)-N-(cyclopentylmethyl)-3-[(3S,5R)-3,5-dibenzyl...)
Affinity DataKi:  0.5nMAssay Description:Compound was assayed for inhibition against HIV protease activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.600nMAssay Description:Compound was assayed for inhibition against HIV protease activityMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073365((S)-2-(3-{(R)-3-[Cyclopentylmethyl-(4-methoxy-phen...)
Affinity DataKi:  7nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378535(CHEMBL1204012)
Affinity DataKi:  7nMAssay Description:Inhibition of JAK2 by radiometric assayMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073364(CHEMBL122542 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  15nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073368(CHEMBL119490 | N-Cyclopentylmethyl-N-[(S)-3-((S)-3...)
Affinity DataKi:  15nMAssay Description:Compound was assayed for inhibition against HIV protease activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073369(CHEMBL433187 | N-[(S)-3-((S)-3-Benzyl-5-oxo-1,4-di...)
Affinity DataKi:  17nMAssay Description:Compound was assayed for inhibition against HIV protease activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073353(CHEMBL332611 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  17nMAssay Description:Compound was assayed for inhibition against HIV protease activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073353(CHEMBL332611 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  17nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073346(CHEMBL119998 | N-{(S)-3-[Cyclopentylmethyl-(4-meth...)
Affinity DataKi:  20nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073350(CHEMBL121146 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  20nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073360(CHEMBL333312 | N-[(S)-3-(3-Benzyl-1-phenethyl-urei...)
Affinity DataKi:  22nMAssay Description:Binding affinity of the compound against HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073356(1N-[3-cyclopentylmethyl(4-methoxyphenyl)sulfonamid...)
Affinity DataKi:  27nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073359(1N-[3-cyclopentylmethyl(4-methoxyphenyl)sulfonamid...)
Affinity DataKi:  29nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297454(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  30nMAssay Description:Inhibition of p38alpha by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073347(CHEMBL331105 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  38nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073340(CHEMBL120843 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  38nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073366(CHEMBL122936 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  40nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073362(CHEMBL264550 | N-Cyclopentylmethyl-N-{(S)-2-hydrox...)
Affinity DataKi:  43nMAssay Description:Binding affinity of the compound against HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073354(CHEMBL331879 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  50nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099331(4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidaz...)
Affinity DataKi:  60nMAssay Description:Inhibition of p38alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073357(CHEMBL332564 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  65nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073363(CHEMBL121254 | N-{(S)-3-[Cyclopentylmethyl-(4-meth...)
Affinity DataKi:  66nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  70nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073341(1N-[3-cyclopentylmethyl(4-methoxyphenyl)sulfonamid...)
Affinity DataKi:  76nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  90nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297456(6-bromo-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)m...)
Affinity DataKi:  100nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073348(CHEMBL124161 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  104nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073339(CHEMBL331429 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  125nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297457(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  140nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297458((Z)-methyl 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-y...)
Affinity DataKi:  160nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50303076((R)-3-(6-(1-(4-fluorophenyl)-2-methylpropylamino)p...)
Affinity DataKi:  160nMAssay Description:Inhibition of FLT3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073355(CHEMBL123186 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  173nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297459(4-bromo-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)m...)
Affinity DataKi:  185nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297460(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  200nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073351(CHEMBL333037 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  200nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073352(1N-[3-cyclopentylmethyl(4-methoxyphenyl)sulfonamid...)
Affinity DataKi:  220nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)
Affinity DataKi:  220nMAssay Description:Inhibition of p38beta using KRELVEPLTPSGEAPNQALLR as substrate for 10 mins by lactate dehydrogenase-coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297461((3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-...)
Affinity DataKi:  230nMAssay Description:Inhibition of p38alpha by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297462(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  240nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50073338(CHEMBL121023 | {(S)-3-[Cyclopentylmethyl-(4-methox...)
Affinity DataKi:  300nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297463(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  300nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297464(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  330nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378535(CHEMBL1204012)
Affinity DataKi:  400nMAssay Description:Inhibition of JAK3 by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297465(6-amino-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)m...)
Affinity DataKi:  400nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297466((3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl...)
Affinity DataKi:  440nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  450nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297467(CHEMBL564616 | N-(1-((6-fluoro-4H-benzo[d][1,3]dio...)
Affinity DataKi:  460nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297468(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  510nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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