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Found 477 with Last Name = 'penvose-yi' and Initial = 'j'
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072528((6S,8aS)-2-[3-(3,4-Dichloro-phenyl)-propionyl]-4-o...)
Affinity DataKi:  0.106nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072536((6S,8aS)-2-(3-Naphthalen-1-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.350nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072524((6S,8aS)-4-Oxo-2-[3-(2-trifluoromethyl-phenyl)-pro...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072527((6S,8aS)-4-Oxo-2-(3-p-tolyl-propionyl)-octahydro-p...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072534((6S,8aS)-2-(3-Naphthalen-2-yl-propionyl)-4-oxo-oct...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072537((6S,8aS)-2-[3-(4-Methoxy-phenyl)-propionyl]-4-oxo-...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072532((6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-py...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072520((6S,8aS)-2-[3-(2-Fluoro-phenyl)-propionyl]-4-oxo-o...)
Affinity DataKi:  0.920nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072533((6S,8aS)-4-Oxo-2-(4-phenyl-butyryl)-octahydro-pyrr...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080924(CHEMBL83260 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  1.20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072530((6S,8aS)-4-Oxo-2-phenylacetyl-octahydro-pyrrolo[1,...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072541((6S,8aS)-4-Oxo-2-(3-pyridin-2-yl-propionyl)-octahy...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072519((6S,8aS)-2-[(S)-2-Amino-3-(4-fluoro-phenyl)-propio...)
Affinity DataKi:  3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080911(2-((S)-4-Benzyl-2-naphthalen-2-ylmethyl-3,6-dioxo-...)
Affinity DataKi:  3.5nMAssay Description:Inhibitory concentration of the compound required against thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072529((6S,8aS)-2-((S)-2-Hydroxy-3-phenyl-propionyl)-4-ox...)
Affinity DataKi:  4.40nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072535((6S,8aS)-4-Oxo-2-(3-phenoxy-propionyl)-octahydro-p...)
Affinity DataKi:  5nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080920(CHEMBL313769 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  8nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072521((6S,8aS)-4-Oxo-2-(2-phenoxy-acetyl)-octahydro-pyrr...)
Affinity DataKi:  16nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072538((6S,8aS)-4-Oxo-2-(3-phenyl-propyl)-octahydro-pyrro...)
Affinity DataKi:  17nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072526((6S,8aS)-2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propi...)
Affinity DataKi:  18nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080916(CHEMBL84084 | N-[(S)-1-(1-Carbamimidoyl-piperidin-...)
Affinity DataKi:  20nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072539((6S,8aS)-2-(3-Cyclohexyl-propionyl)-4-oxo-octahydr...)
Affinity DataKi:  24nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072540((6S,8aS)-2-Benzoyl-4-oxo-octahydro-pyrrolo[1,2-a]p...)
Affinity DataKi:  25nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072525((6S,8aS)-4-Oxo-2-(1,2,3,4-tetrahydro-isoquinoline-...)
Affinity DataKi:  32nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080915(2-((R)-2-Benzyl-4-butyl-3,6-dioxo-piperazin-1-yl)-...)
Affinity DataKi:  32nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072518((6S,8aS)-6-[4-Guanidino-1-(thiazole-2-carbonyl)-bu...)
Affinity DataKi:  50nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080918(CHEMBL408553 | N-[(S)-1-(1-Carbamimidoyl-piperidin...)
Affinity DataKi:  55nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080930(2-[(R)-2-Benzyl-3,6-dioxo-4-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  55nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080913((S)-2-{2-[(R)-2-Benzyl-3,6-dioxo-4-(3-phenyl-propy...)
Affinity DataKi:  55nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072523((6S,8aS)-4-Oxo-hexahydro-pyrrolo[1,2-a]pyrazine-2,...)
Affinity DataKi:  58nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072531((6S,8aS)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propiony...)
Affinity DataKi:  75nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072531((6S,8aS)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propiony...)
Affinity DataKi:  75.3nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080917(CHEMBL83001 | N-[(S)-2-Benzothiazol-2-yl-1-(1-carb...)
Affinity DataKi:  80nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072522((6S,8aS)-2-((S)-2-Hydroxy-2-phenyl-acetyl)-4-oxo-o...)
Affinity DataKi:  84nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50072522((6S,8aS)-2-((S)-2-Hydroxy-2-phenyl-acetyl)-4-oxo-o...)
Affinity DataKi:  84nMAssay Description:Binding affinity of the compound against thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080914(2-[(R)-2-Benzyl-3,6-dioxo-4-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  130nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Biochem Therapeutic

Curated by ChEMBL
LigandPNGBDBM50080912(2-[(R)-2-Benzyl-3,6-dioxo-4-(3-phenyl-propyl)-pipe...)
Affinity DataKi:  825nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataIC50:  0.400nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataIC50:  1.10nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m3 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462((R)-Trihexyphenidyl | (S)-Trihexyphenidyl | Benzhe...)
Affinity DataIC50:  1.30nMAssay Description:Evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]NMS binding using membranes in transfected chinese hamster ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataIC50:  1.80nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m1 by displacement of [3H]-NMS radioligand using membranes in transfecte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataIC50:  2.30nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]-NMS radioligand using membranes from tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataIC50:  2.30nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS radioligand using membranes from trans...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataIC50:  3.80nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataIC50:  4.30nMAssay Description:Compound was evaluated for its binding affinity at human muscarinic receptor m2 by displacement of [3H]NMS radioligand using membranes from transfect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462((R)-Trihexyphenidyl | (S)-Trihexyphenidyl | Benzhe...)
Affinity DataIC50:  6.70nMAssay Description:Evaluated for its binding affinity at human muscarinic receptor m4 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50073501(1-Ethyl-4-phenyl-1,2,5,6-tetrahydro-pyridine-3-car...)
Affinity DataIC50:  8.80nMAssay Description:Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M1 using membranes from transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM50073492(1-Ethyl-4-phenyl-1,2,5,6-tetrahydro-pyridine-3-car...)
Affinity DataIC50:  9.60nMAssay Description:Displacement of [3H]NMS binding to human Muscarinic acetylcholine receptor M1 using membranes from transfected CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M5(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

Curated by ChEMBL
LigandPNGBDBM81462((R)-Trihexyphenidyl | (S)-Trihexyphenidyl | Benzhe...)
Affinity DataIC50:  10nMAssay Description:Evaluated for its binding affinity at human muscarinic receptor m5 by the displacement of [3H]NMS binding using membranes from transfected chinese ha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

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