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Found 351 with Last Name = 'philpott' and Initial = 'm'
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  4nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505576(CHEMBL4458252)
Affinity DataIC50:  6nMAssay Description:Inhibition of G9a (unknown origin) by scintillation proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-801](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  7nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C [1-765](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  13nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5D [1-775](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  15nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-801](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50:  24nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50210164(CHEMBL2132936)
Affinity DataIC50:  25nMAssay Description:Inhibition of [3H]-Nalpha-methylhistamine binding to H3 receptor in guinea-pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50:  26nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505574(CHEMBL4451634)
Affinity DataIC50:  33nMAssay Description:Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505583(CHEMBL4573889)
Affinity DataIC50:  48nMAssay Description:Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505578(CHEMBL4570122)
Affinity DataIC50:  59nMAssay Description:Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C [1-765](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50:  65nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5D [1-775](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM195612(GSK467)
Affinity DataIC50:  77nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase EHMT2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505582(CHEMBL4465568)
Affinity DataIC50:  120nMAssay Description:Inhibition of G9a (unknown origin) by scintillation proximity AssayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain adjacent to zinc finger domain protein 2A(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50078630(CHEMBL4296718)
Affinity DataIC50:  136nMAssay Description:Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...More data for this Ligand-Target Pair
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505573(CHEMBL4577068)
Affinity DataIC50:  152nMAssay Description:Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495426(CHEMBL3108801)
Affinity DataIC50:  158nMAssay Description:Displacement of H4Ac4 peptide from BRD4 bromodomain-1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495431(CHEMBL3108800)
Affinity DataIC50:  158nMAssay Description:Displacement of H4Ac4 peptide from CECR2 bromodomain (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 6B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM60875(3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(...)
Affinity DataIC50:  160nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
TargetBromodomain adjacent to zinc finger domain protein 2A(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50148289(CHEMBL3770199)
Affinity DataIC50:  160nMAssay Description:Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50078630(CHEMBL4296718)
Affinity DataIC50:  174nMAssay Description:Displacement of H3K14Ac from BAZ2B (unknown origin) preincubated for 30 mins with non-biotinylated peptide followed by addition of biotinylated pepti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50399443(CHEMBL2179385)
Affinity DataIC50:  180nMAssay Description:Inhibition of BRD4 isoform 1 by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50446376(CHEMBL3109630)
Affinity DataIC50:  186nMAssay Description:Binding affinity to recombinant human His-tagged SPIN1 (49 to 262 residues) expressed in Escherichia coli BL21 (DE3) incubated for 30 mins by AlphaLI...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50430826(CHEMBL2335155)
Affinity DataIC50:  199nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50430826(CHEMBL2335155)
Affinity DataIC50:  200nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495426(CHEMBL3108801)
Affinity DataIC50:  200nMAssay Description:Displacement of H2K9(Ac)K13(Ac)K15(Ac) peptide from BRD9 bromodomain (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetCREB-binding protein(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495426(CHEMBL3108801)
Affinity DataIC50:  200nMAssay Description:Displacement of H3K56(Ac) peptide from CREBBP bromodomain (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  210nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50399442(CHEMBL2179386)
Affinity DataIC50:  220nMAssay Description:Inhibition of BRD4 isoform 1 by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50399434(CHEMBL2179387)
Affinity DataIC50:  220nMAssay Description:Inhibition of BRD4 isoform 1 by AlphaScreen assayMore data for this Ligand-Target Pair
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495429(CHEMBL3108781)
Affinity DataIC50:  251nMAssay Description:Displacement of H4Ac4 peptide from CECR2 bromodomain (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495431(CHEMBL3108800)
Affinity DataIC50:  251nMAssay Description:Displacement of H4Ac4 peptide from BRD4 bromodomain-1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50266286(CHEMBL4650213)
Affinity DataIC50:  263nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 3A(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM26106(CHEMBL90852 | N-oxalyl glycine, 1a | NOG | Oxalylg...)
Affinity DataIC50:  290nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495431(CHEMBL3108800)
Affinity DataIC50:  316nMAssay Description:Displacement of H2K9(Ac)K13(Ac)K15(Ac) peptide from BRD9 bromodomain (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCREB-binding protein(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50266292(CHEMBL3906203)
Affinity DataIC50:  324nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505579(CHEMBL4591023)
Affinity DataIC50:  340nMAssay Description:Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505571(CHEMBL4528213)
Affinity DataIC50:  360nMAssay Description:Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50399441(CHEMBL2179388)
Affinity DataIC50:  360nMAssay Description:Inhibition of BRD4 isoform 1 by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50148282(CHEMBL3771216)
Affinity DataIC50:  370nMAssay Description:Inhibition of recombinant His6-TEV fused human BAZ2B expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSpindlin-1(Homo sapiens)
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50505570(CHEMBL4476309)
Affinity DataIC50:  390nMAssay Description:Displacement of trimethylated biotinylated histone H3 peptide from recombinant human His-tagged SPIN1 (26 to 262 residues) expressed in Escherichia c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50399440(CHEMBL2179389)
Affinity DataIC50:  390nMAssay Description:Inhibition of BRD4 isoform 1 by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain adjacent to zinc finger domain protein 2A(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50148270(CHEMBL3739699)
Affinity DataIC50:  400nMAssay Description:Inhibition of recombinant His6-TEV fused human BAZ2A expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...More data for this Ligand-Target Pair
TargetBromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50148283(CHEMBL3770155)
Affinity DataIC50:  410nMAssay Description:Inhibition of recombinant His6-TEV fused human BAZ2B expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscription activator BRG1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50266286(CHEMBL4650213)
Affinity DataIC50:  411nMAssay Description:Inhibition of human BRD4 BD1 (67 to 152 residues) preincubated for 15 mins followed by addition of C-terminal biotinylated synthetic K5,8,12,16 tetra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50148270(CHEMBL3739699)
Affinity DataIC50:  430nMAssay Description:Inhibition of recombinant His6-TEV fused human BAZ2B expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50399439(CHEMBL2179390)
Affinity DataIC50:  470nMAssay Description:Inhibition of BRD4 isoform 1 by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495428(CHEMBL3110357)
Affinity DataIC50:  501nMAssay Description:Displacement of H2K9(Ac)K13(Ac)K15(Ac) peptide from BRD9 bromodomain (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50495428(CHEMBL3110357)
Affinity DataIC50:  501nMAssay Description:Displacement of H4Ac4 peptide from CECR2 bromodomain (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain adjacent to zinc finger domain protein 2B(Homo sapiens (Human))
Cancer Research Uk Cancer Therapeutics Unit

Curated by ChEMBL
LigandPNGBDBM50148284(CHEMBL3770449)
Affinity DataIC50:  540nMAssay Description:Inhibition of recombinant His6-TEV fused human BAZ2B expressed in Escherichia coli incubated for 30 mins in presence of biotinylated peptide by alpha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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