Affinity DataKi: 3nMAssay Description:Compound was evaluated for its binding affinity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3 protease.More data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataKi: 600nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataKi: 1.40E+4nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of human liver Cathepsin BMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: <60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Activity against serine protease porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Activity against serine protease porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Boehringer Ingelheim (Canada)
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Activity against serine protease porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Activity against serine protease porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Micro molar potency of the compound to inhibit human cytomegalovirus (HCMV) proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Activity against serine protease porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
Affinity DataIC50: 350nMAssay Description:Inhibition of HIV1 integrase by LTR cleavage assayMore data for this Ligand-Target Pair
Affinity DataIC50: 390nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of human liver CYP3A4More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Concentration required for inhibiting hepatitis C virus NS5B RNA polymerase activity.More data for this Ligand-Target Pair