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Found 583 with Last Name = 'ramsden' and Initial = 'n'
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315314(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM22914(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM22566(5-chloro-2-[(4-methylpiperazin-1-yl)carbonyl]-1H-i...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]histamine human recombinant histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315348((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387544(CHEMBL2057373)
Affinity DataIC50:  2.51nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387541(CHEMBL2057368)
Affinity DataIC50:  2.51nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315348((R)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  3nMAssay Description:Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387546(CHEMBL2057363)
Affinity DataIC50:  3.16nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387543(CHEMBL2057372)
Affinity DataIC50:  3.98nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315349((S)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  4nMAssay Description:Inverse agonist activity at human histamine H4 receptor assessed as inhibition of [35S]GTPgammaS binding after 15 mins by scintillation proximity ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389412(CHEMBL2064508)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387542(CHEMBL2057371)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387539(CHEMBL2057366)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387541(CHEMBL2057368)
Affinity DataIC50:  6.31nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401144(CHEMBL2205771)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389427(CHEMBL2064507)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389431(CHEMBL2064501)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387538(CHEMBL2057365)
Affinity DataIC50:  7.94nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387540(CHEMBL2057367)
Affinity DataIC50:  10nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387544(CHEMBL2057373)
Affinity DataIC50:  12.6nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387536(CHEMBL2057362)
Affinity DataIC50:  12.6nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387530(CHEMBL2059910)
Affinity DataIC50:  12.6nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50:  13nMAssay Description:Inhibition of CK2a1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315349((S)-8-chloro-4-(3-(methylamino)pyrrolidin-1-yl)ben...)
Affinity DataIC50:  13nMAssay Description:Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387548(CHEMBL2059913)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387527(CHEMBL2057370)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387538(CHEMBL2057365)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389391(CHEMBL2064512)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387543(CHEMBL2057372)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401150(CHEMBL2205763)
Affinity DataIC50:  16nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078544(3-[(3R,3aS,8aS)-1-Benzenesulfonyl-3-(4-carbamimido...)
Affinity DataIC50:  16nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078554((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  16nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50315314(8-chloro-4-(4-methylpiperazin-1-yl)benzofuro[3,2-d...)
Affinity DataIC50:  19nMAssay Description:Displacement of [3H]histamine dihydrochloride from human histamine H4 receptor after 2.5 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387548(CHEMBL2059913)
Affinity DataIC50:  19.9nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401149(CHEMBL2205773)
Affinity DataIC50:  20nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401147(CHEMBL2205768)
Affinity DataIC50:  20nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401153(CHEMBL2205767)
Affinity DataIC50:  20nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401146(CHEMBL2205772)
Affinity DataIC50:  25nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401143(CHEMBL2205774)
Affinity DataIC50:  25nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401152(CHEMBL2205766)
Affinity DataIC50:  25nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389420(CHEMBL2064571)
Affinity DataIC50:  25nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50401148(CHEMBL2205765)
Affinity DataIC50:  25nMAssay Description:Inhibition of PIK3CgMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387529(CHEMBL2059909)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50389420(CHEMBL2064571)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kgamma by high throughput chemoproteomics binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387535(CHEMBL2057361)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387537(CHEMBL2057364)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387529(CHEMBL2059909)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387536(CHEMBL2057362)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kgamma in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50387539(CHEMBL2057366)
Affinity DataIC50:  25.1nMAssay Description:Inhibition of PI3Kdelta in human HL60 cell lysate by kinobead assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Glaxo Wellcome Research And Development

Curated by ChEMBL
LigandPNGBDBM50078554((3R,3aS,8aS)-3-(4-Carbamimidoyl-butyl)-6-(3-diethy...)
Affinity DataIC50:  30nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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