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Found 306 with Last Name = 'sakai' and Initial = 't'
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089536(5-[(6,6-Dimethyl-hepta-2,4-diynyl)-methyl-amino]-3...)
Affinity DataIC50:  0.140nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089557(5-[Butyl-((E)-6,6-dimethyl-hept-2-en-4-ynyl)-amino...)
Affinity DataIC50:  0.350nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272596(CHEMBL4126450)
Affinity DataIC50:  0.470nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089551(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-propyl-amin...)
Affinity DataIC50:  0.680nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089540(CHEMBL32125 | Phosphoric acid 5-[(6,6-dimethyl-hep...)
Affinity DataIC50:  0.760nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089563(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-ethyl-amino...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272602(CHEMBL4126877)
Affinity DataIC50:  0.910nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089538(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-pentyl-amin...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089559(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-isopropyl-a...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272605(CHEMBL4128542)
Affinity DataIC50:  1.40nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272606(CHEMBL4125917)
Affinity DataIC50:  2.10nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089543(5-[((E)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-amin...)
Affinity DataIC50:  2.80nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089547(5-[(6,6-Dimethyl-hepta-2,4-diynyl)-methyl-amino]-3...)
Affinity DataIC50:  3nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272607(CHEMBL4126057)
Affinity DataIC50:  4.30nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184863(CHEMBL202919 | N-(2-Chlorobenzoyl)-N'-{4-[(6,7-dim...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184860(CHEMBL380703 | Phenyl N-{4-[(6,7-Dimethoxy-4-quino...)
Affinity DataIC50:  5nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184864(CHEMBL203279 | N-{4-[(6,7-Dimethoxy-4-quinazolinyl...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184858(CHEMBL425935 | N-(2-Cyclohexyl)ethyl-N'-{4-[(6,7-d...)
Affinity DataIC50:  6nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  7nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089537(5-{[4-(3,3-Dimethyl-but-1-ynyl)-benzyl]-methyl-ami...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184857(CHEMBL203227 | N-{4-[(6,7-Dimethoxy-4-quinolyl)oxy...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cell by transactivation enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272604(CHEMBL4129011)
Affinity DataIC50:  7.80nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089560(5-(Hepta-2,4-diynyl-methyl-amino)-3,4-dihydro-1H-q...)
Affinity DataIC50:  7.90nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50365262((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...)
Affinity DataIC50:  8nMAssay Description:Inhibition of BRD4 bromodomain-1 (unknown origin) by europium based LANCE TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184868(CHEMBL378489 | N-Benzoyl-N'-{4-[(6,7-dimethoxy-4-q...)
Affinity DataIC50:  8nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50261663(CHEMBL4079960)
Affinity DataIC50:  8nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184856(CHEMBL204225 | N-(2-Cyclohexyl)ethyl-N'-{4-[(6,7-d...)
Affinity DataIC50:  9nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089550(5-[(6,6-Dimethyl-hept-4-ynyl)-methyl-amino]-3,4-di...)
Affinity DataIC50:  9nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272608(CHEMBL4125688)
Affinity DataIC50:  9.70nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50189627(CHEMBL212460 | N-{3-[4-(4-isopropoxyphenoxy)phenyl...)
Affinity DataIC50:  11nMAssay Description:Inhibition of full length recombinant C-terminal His-tagged human ACC2 expressed in baculovirus infected sf9 cells using acetyl-CoA as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089562(3-Amino-5-[(6,6-dimethyl-hepta-2,4-diynyl)-methyl-...)
Affinity DataIC50:  12nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184870(CHEMBL205953 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  12nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272592(CHEMBL4125724)
Affinity DataIC50:  12nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089561(5-[((Z)-6,6-Dimethyl-hept-2-en-4-ynyl)-methyl-amin...)
Affinity DataIC50:  13nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272595(CHEMBL4127153)
Affinity DataIC50:  13nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitin synthase 1(Candida albicans)
Nippon Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50089535((R)-2-Amino-3-methyl-butyric acid 5-[(6,6-dimethyl...)
Affinity DataIC50:  15nMAssay Description:Inhibitory of Candida albicans chitin synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184859(CHEMBL204120 | N-Cyclohexylcarbonyl-N'-{4-[(6,7-di...)
Affinity DataIC50:  15nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 2(Homo sapiens (Human))
The University Of Tokyo

Curated by ChEMBL
LigandPNGBDBM50198340(CHEMBL3965346)
Affinity DataIC50:  16nMAssay Description:Inhibition of full length recombinant C-terminal His-tagged human ACC2 expressed in baculovirus infected sf9 cells using acetyl-CoA as substrate afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184867(2-Cyclohexylethyl N-{4-[(6,7-Dimethoxy-4-quinolyl)...)
Affinity DataIC50:  18nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184860(CHEMBL380703 | Phenyl N-{4-[(6,7-Dimethoxy-4-quino...)
Affinity DataIC50:  19nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184870(CHEMBL205953 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  22nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141817(CHEMBL171509 | [1-(2-{4-[4-(4-tert-Butyl-phenylami...)
Affinity DataIC50:  23nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184861(CHEMBL205089 | N-Cyclohexyl-N'-{4-[6,7-dimethoxy-4...)
Affinity DataIC50:  27nMAssay Description:Inhibition of c-kit receptor phosphorylation in M07e cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184869(1-(4-(6,7-dimethoxyquinolin-4-yloxy)phenyl)-3-(2-p...)
Affinity DataIC50:  28nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272591(CHEMBL4128835)
Affinity DataIC50:  31nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50272594(CHEMBL4130093)
Affinity DataIC50:  32nMAssay Description:Agonist activity at CaSR in rat parathyroid cells assessed as inhibition of PTH (1 to 84 residues) production in presence of Cacl2 by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184866(CHEMBL382399 | N-Cyclohexylmethyl-N'-{4-[(6,7-dime...)
Affinity DataIC50:  37nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50141829((4-tert-Butyl-phenyl)-[4-(6,7-dimethoxy-quinolin-4...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibition against autophosphorylation of Fibroblast growth factor receptor 2 in the human scirrhous gastric carcinoma cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Kirin Brewery

Curated by ChEMBL
LigandPNGBDBM50184865(1-cyclohexyl-3-(4-(6,7-dimethoxyquinolin-4-yloxy)p...)
Affinity DataIC50:  40nMAssay Description:Inhibition of PDGFR alpha phosphorylation in G292 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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