Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 5nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 8.10nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 8.40nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 21nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 26nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 68nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 87nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 94nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 97nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD4 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataKi: 240nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 340nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 560nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 590nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 660nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 670nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 900nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.40E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.40E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.60E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.60E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.60E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.70E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >1.80E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine D2 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 2.90E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >4.40E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.40E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: >4.50E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 4.50E+3nMAssay Description:Displacement of [3H]-spiperone from human dopamine receptor subtype hD3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 0.850nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Merck Sharp & Dohme Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:In vitro inhibition of gamma-secretase as amyloid peptide production in SH-SY5Y cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 5.5nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Binding affinity of compound was determined from inhibition of [125I]- substance P binding to the hNK1 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Binding affinity of the compound towards human Tachykinin receptor 1 expressed in CHO cells by the displacement of [125 I] substance PMore data for this Ligand-Target Pair