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Found 4 Enz. Inhib. hit(s) with Target = 'Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2' and Ligand = 'BDBM50166702'
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibition of gamma-secretase as amyloid peptide production in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  14nMAssay Description:Inhibition of gamma-secretase in HEK293 cell membranes using SPC99-Lon as substrate assessed as formation of amyloid beta 40 after 1 hr by electroche...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  27nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 42 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50166702(2-(1-(4-chlorophenylsulfonyl)cyclohexyl)-1,4-diflu...)
Affinity DataIC50:  41nMAssay Description:Inhibition of gamma-secretase in HEK293 cells using human APP Swedish/London double mutant as substrate assessed as formation of amyloid beta 40 afte...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed