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Found 127 with Last Name = 'tsuchiya' and Initial = 'm'
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262566((2S,3S)-3-[(1R)-6-Methoxy-1-methyl-1-trifluorometh...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataKi:  20nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262280(CHEMBL513351 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataKi:  70nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataKi:  120nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262567(((2S,3S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataKi:  420nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262279((2S,3S)-N-((6-methoxy-3-methyl-3-(trifluoromethyl)...)
Affinity DataKi:  660nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224198((2S,3S)-N-(2-methoxy-5-(1,1,1-trifluoro-2-methylpr...)
Affinity DataKi:  840nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262337((2S,3S)-N-(5-(1,1,1,3,3,3-hexafluoropropan-2-yl)-2...)
Affinity DataKi:  2.10E+3nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262281((2S,3S)-3-[2-Methoxy-5-(2,2,2-trifluoroethyl)benzy...)
Affinity DataKi:  4.25E+3nMAssay Description:Binding affinity to human CYP2D6 using bufuralol as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069868((2,5-Dimethoxy-benzyl)-((2S,3S)-2-phenyl-piperidin...)
Affinity DataIC50:  0.0900nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069863(CHEMBL329007 | N-{4-Methoxy-3-[((2S,3S)-2-phenyl-p...)
Affinity DataIC50:  0.110nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069870((2-Ethoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-ph...)
Affinity DataIC50:  0.140nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069864((5-Chloro-2-methoxy-benzyl)-((2S,3S)-2-phenyl-pipe...)
Affinity DataIC50:  0.140nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262279((2S,3S)-N-((6-methoxy-3-methyl-3-(trifluoromethyl)...)
Affinity DataIC50:  0.160nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069865((2-Isopropoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-...)
Affinity DataIC50:  0.180nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataIC50:  0.190nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50224198((2S,3S)-N-(2-methoxy-5-(1,1,1-trifluoro-2-methylpr...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50178014(CHEMBL370164 | N-(4-chlorophenyl)-2-(5-phenyl-7-(5...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50174602((4R,5R,6S)-5-[4-(4-Fluoro-phenylamino)-5-phenyl-py...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against human recombinant adenosine kinase using [14C]-AMP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262510(CHEMBL477365 | R/S-(2S,3S)-3-[((6-Methoxy-1-methyl...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50261732((2S,3S)-N-(((S)-6-methoxy-1-methyl-1-(trifluoromet...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262280(CHEMBL513351 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50067935((2-Methoxy-5-trifluoromethoxy-benzyl)-((2S,3S)-2-p...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069862((2-Difluoromethoxy-benzyl)-((2S,3S)-2-phenyl-piper...)
Affinity DataIC50:  0.410nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069867((2-Isopropoxy-benzyl)-((2S,3S)-2-phenyl-piperidin-...)
Affinity DataIC50:  0.460nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50134740((1R,4S,5R)-2-Hydroxymethyl-5-(5-phenyl-4-phenylami...)
Affinity DataIC50:  0.470nMAssay Description:Inhibitory concentration against human recombinant adenosine kinase using [14C]-AMP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50030232((S)-((S)-2-Benzhydryl-1-aza-bicyclo[2.2.2]oct-3-yl...)
Affinity DataIC50:  0.480nMAssay Description:Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50000041((+) (2-Methoxy-benzyl)-(2-phenyl-piperidin-3-yl)-a...)
Affinity DataIC50:  0.490nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262453(CHEMBL479049 | R/S-(2S,3S)-N-((3-methoxy-8-(triflu...)
Affinity DataIC50:  0.5nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090887((1R,4S,5R)-2-Methyl-5-(5-phenyl-4-phenylamino-pyrr...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50178015(2-(5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)-pyrro...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50178003(CHEMBL370011 | N-cyclopropyl-2-(5-phenyl-7-(5-deox...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090887((1R,4S,5R)-2-Methyl-5-(5-phenyl-4-phenylamino-pyrr...)
Affinity DataIC50:  0.5nMAssay Description:Inhibitory concentration against human recombinant adenosine kinase using [14C]-AMP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069860((5-Dimethylamino-2-methoxy-benzyl)-((2S,3S)-2-phen...)
Affinity DataIC50:  0.560nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50178007(2-(5-phenyl-7-(beta-D-erythrofuranosyl)-pyrrolo[2,...)
Affinity DataIC50:  0.600nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50001450((SP)Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH...)
Affinity DataIC50:  0.610nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262336(CHEMBL468163 | R/S-(2S,3S)-N-(2-methoxy-5-(1,2,2,2...)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50090883((1R,4S,5R)-2-Hydroxymethyl-5-(5-phenyl-4-phenylami...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory concentration against human recombinant adenosine kinase using [14C]-AMP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50069869(((2S,3S)-2-Phenyl-piperidin-3-yl)-(2-trifluorometh...)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity for Tachykinin receptor 1 as displacement of [3H]-Substance P in human IM-9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50178023(2-(5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)-pyrro...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50134753((1R,4S,5R)-2-Methyl-5-(5-phenyl-4-phenylamino-pyrr...)
Affinity DataIC50:  0.800nMAssay Description:Inhibitory concentration against human recombinant adenosine kinase using [14C]-AMP as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262395(CHEMBL478620 | R/S-(2S,3S)-N-((6-methoxy-3-(triflu...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50178018(2-(3-phenyl-1-(beta-D-ribofuranosyl)-pyrazolo[3,4-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262281((2S,3S)-3-[2-Methoxy-5-(2,2,2-trifluoroethyl)benzy...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262394(CHEMBL515935 | R/S-(2S,3S)-N-(2-methoxy-5-(1,1,1-t...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]spiperone from NK1 receptor in human IM9 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSubstance-P receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50030236((S)-((S)-8-Benzhydryl-7-aza-tricyclo[4.3.1.0*3,7*]...)
Affinity DataIC50:  0.920nMAssay Description:Tested in vitro for the binding affinity towards NK1 receptor in human IM-9 cells using [125I]-labeled bolton-hunter substance P as ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine kinase(Homo sapiens (Human))
Metabasis Therapeutics

Curated by ChEMBL
LigandPNGBDBM50178027(CHEMBL438449 | N-cyclopentyl-2-(5-phenyl-7-(5-deox...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against recombinant human adenosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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