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Found 1178 with Last Name = 'tucker' and Initial = 'tj'
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581548(CHEMBL5085124)
Affinity DataKi:  0.000600nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581547(CHEMBL5081349)
Affinity DataKi:  0.000930nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581546(CHEMBL5084416)
Affinity DataKi:  0.00239nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056769((S)-1-(3,3-Diphenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.00250nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581547(CHEMBL5081349)
Affinity DataKi:  0.00736nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581545(CHEMBL5084902)
Affinity DataKi:  0.00813nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581544(CHEMBL5086475)
Affinity DataKi:  0.00826nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581544(CHEMBL5086475)
Affinity DataKi:  0.00940nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET ultra assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581548(CHEMBL5085124)
Affinity DataKi: <0.0100nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581546(CHEMBL5084416)
Affinity DataKi:  0.0114nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581549(CHEMBL5082483)
Affinity DataKi:  0.0370nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057826((S)-1-((R)-2-Amino-3,3-dicyclohexyl-propionyl)-pyr...)
Affinity DataKi:  0.0560nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50454822(CHEMBL2062141 | L-370518)
Affinity DataKi:  0.0900nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50063555(1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-c...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056773((S)-1-(2-Amino-3,3-diphenyl-propionyl)-pyrrolidine...)
Affinity DataKi:  0.100nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057828((S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrroli...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50057827(((R)-2-{(S)-2-[(4-Amino-cyclohexylmethyl)-carbamoy...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against human thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581545(CHEMBL5084902)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581544(CHEMBL5086475)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581548(CHEMBL5085124)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581547(CHEMBL5081349)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581546(CHEMBL5084416)
Affinity DataKi: >0.129nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581542(CHEMBL5081587)
Affinity DataKi:  0.160nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581542(CHEMBL5081587)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581540(CHEMBL5087487)
Affinity DataKi:  0.230nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50006828(2-(2-{[1-(3-{2-[2-(2-Amino-3-hydroxy-propionylamin...)
Affinity DataKi:  0.240nMAssay Description:Compound was evaluated in vitro for the inhibition of HIV-Protease, using a peptide hydrolysis assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581537(CHEMBL5086286)
Affinity DataKi:  0.25nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50060708((S)-1-(3-Benzo[1,3]dioxol-5-yl-3-pyridin-3-yl-prop...)
Affinity DataKi:  0.280nM Koff:  2.51E+3s-1Assay Description:Inhibition of ThrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  0.300nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484039(CHEMBL1800087)
Affinity DataKi:  0.300nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484029(CHEMBL1801258)
Affinity DataKi:  0.300nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066331((S)-1-[(R)-2-Cyclohexyl-2-(diethylcarbamoylmethyl-...)
Affinity DataKi:  0.310nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581535(CHEMBL5091040)
Affinity DataKi:  0.390nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET plus assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50056774((S)-1-((R)-3-Phenyl-2-phenylmethanesulfonylamino-p...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity towards thrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)
Affinity DataKi:  0.400nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484030(CHEMBL1801256)
Affinity DataKi:  0.400nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581537(CHEMBL5086286)
Affinity DataKi:  0.430nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066338(CHEMBL327115 | [2-({[(S)-1-((R)-2-Amino-2-cyclohex...)
Affinity DataKi:  0.450nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581540(CHEMBL5087487)
Affinity DataKi:  0.450nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProprotein convertase subtilisin/kexin type 9(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50581535(CHEMBL5091040)
Affinity DataKi:  0.480nMAssay Description:Inhibition of human PCSK9 using Alexa Fluor 674 as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484045(CHEMBL1801257)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by electrochemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484030(CHEMBL1801256)
Affinity DataKi:  0.5nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484045(CHEMBL1801257)
Affinity DataKi:  0.5nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066332((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484030(CHEMBL1801256)
Affinity DataKi:  0.600nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by electrochemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484029(CHEMBL1801258)
Affinity DataKi:  0.600nMAssay Description:Inhibition of HIV1 reverse transcriptase Y181C mutant by electrochemiluminescent assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50066333((S)-1-((R)-2-Amino-2-cyclohexyl-acetyl)-pyrrolidin...)
Affinity DataKi:  0.610nMAssay Description:Binding affinity of the compound was evaluated on serine protease thrombin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484029(CHEMBL1801258)
Affinity DataKi:  0.700nMAssay Description:Inhibition of HIV1 reverse transcriptase K103N mutant by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484032(CHEMBL1801231)
Affinity DataKi:  0.700nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Merck Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50484031(CHEMBL1801255)
Affinity DataKi:  0.700nMAssay Description:Inhibition of wild type HIV1 reverse transcriptase by SPA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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