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Found 484 with Last Name = 'wahhab' and Initial = 'a'
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  8nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24496(3-(3-fluoro-4-{[2-(pyrrolidin-1-ylcarbonyl)thieno[...)
Affinity DataIC50:  9nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277188(CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24500(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-2-yl)thien...)
Affinity DataIC50:  10nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255853(4-(((R)-2,3-dihydro-2-oxo-3-phenethylquinoxalin-4(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255852(4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquino...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24498(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)
Affinity DataIC50:  10nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255096(4-(((R)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24499(3-(4-{[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]py...)
Affinity DataIC50:  11nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24505(3-(3-fluoro-4-{[2-(pyridin-2-yl)thieno[3,2-b]pyrid...)
Affinity DataIC50:  17nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24504(3-(3-fluoro-4-{[2-(1,3-thiazol-2-yl)thieno[3,2-b]p...)
Affinity DataIC50:  17nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24493(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Affinity DataIC50:  19nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24502(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)thieno...)
Affinity DataIC50:  24nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24502(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)thieno...)
Affinity DataIC50:  25nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24501(3-(4-{[2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]py...)
Affinity DataIC50:  25nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24503(3-(3-fluoro-4-{[2-(1-methyl-1H-1,2,4-triazol-5-yl)...)
Affinity DataIC50:  28nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24498(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)
Affinity DataIC50:  29nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24510(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrrol-2-yl)thieno[...)
Affinity DataIC50:  31nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24485(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Affinity DataIC50:  32nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24509(3-(3-fluoro-4-{[2-(thiophen-2-yl)thieno[3,2-b]pyri...)
Affinity DataIC50:  32nMAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255809(4-(((R)-3-(3,4-difluorobenzyl)-2,3-dihydro-2-oxoqu...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255854((R)-tert-butyl 4-(1-(4-(hydroxycarbamoyl)benzyl)-3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255914(4-(((R)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24493(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Affinity DataIC50:  48nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24510(3-(3-fluoro-4-{[2-(1-methyl-1H-pyrrol-2-yl)thieno[...)
Affinity DataIC50:  49nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50300446(CHEMBL583490 | N-hydroxy-9H-xanthene-9-carboxamide)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC7 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50255910(4-(((R)-3-(4-tert-butoxybenzyl)-2,3-dihydro-2-oxoq...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant histone deacetylase 6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24500(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-2-yl)thien...)
Affinity DataIC50:  51nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24499(3-(4-{[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]py...)
Affinity DataIC50:  52nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24496(3-(3-fluoro-4-{[2-(pyrrolidin-1-ylcarbonyl)thieno[...)
Affinity DataIC50:  54nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

LigandPNGBDBM27642(1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...)
Affinity DataIC50:  60nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50277329((S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

LigandPNGBDBM27641(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Affinity DataIC50:  60nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24508(3-(3-fluoro-4-{[2-(1,3,4-thiadiazol-2-yl)thieno[3,...)
Affinity DataIC50:  60nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

LigandPNGBDBM27641(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...)
Affinity DataIC50:  60nMAssay Description:Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24505(3-(3-fluoro-4-{[2-(pyridin-2-yl)thieno[3,2-b]pyrid...)
Affinity DataIC50:  62nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24512(3-(3-fluoro-4-{[2-(pyrimidin-5-yl)thieno[3,2-b]pyr...)
Affinity DataIC50:  63nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50257130((S)-2-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24504(3-(3-fluoro-4-{[2-(1,3-thiazol-2-yl)thieno[3,2-b]p...)
Affinity DataIC50:  65nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24491(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Affinity DataIC50:  65nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24503(3-(3-fluoro-4-{[2-(1-methyl-1H-1,2,4-triazol-5-yl)...)
Affinity DataIC50:  69nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24509(3-(3-fluoro-4-{[2-(thiophen-2-yl)thieno[3,2-b]pyri...)
Affinity DataIC50:  70nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24511(3-(3-fluoro-4-{[2-(furan-3-yl)thieno[3,2-b]pyridin...)
Affinity DataIC50:  74nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone-arginine methyltransferase CARM1(Mus musculus (mouse))
Methylgene

LigandPNGBDBM27659(1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...)
Affinity DataIC50:  80nMpH: 9.0 T: 2°CAssay Description:Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Methylgene

LigandPNGBDBM24492(7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...)
Affinity DataIC50:  80nMpH: 7.5 T: 2°CAssay Description:Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Methylgene

Curated by ChEMBL
LigandPNGBDBM50300443(2,2-bis(3-fluorophenyl)-N-hydroxyacetamide | CHEMB...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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