BindingDB PrimarySearch

Found 962 with Last Name = 'washizuka' and Initial = 'k'

Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511546(CHEMBL4553990)

IC50: 0.100nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511561(CHEMBL4446044)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511570(CHEMBL4442053)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511565(CHEMBL4539435)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511541(CHEMBL4572668)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511553(CHEMBL4532667)

IC50: 0.200nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511536(CHEMBL4585076)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511537(CHEMBL4470270)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511568(CHEMBL4470218)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511539(CHEMBL4457037)

IC50: 0.300nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511538(CHEMBL4466701)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511557(CHEMBL4544771)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511545(CHEMBL4581567)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511548(CHEMBL4449082)

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511556(CHEMBL4525942)

IC50: 0.400nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511555(CHEMBL4464007)

IC50: 0.700nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511542(CHEMBL4467730)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511569(CHEMBL4463639)

IC50: 0.800nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511560(CHEMBL4582280)

IC50: 0.900nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511567(CHEMBL4441063)

IC50: 1.10nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511544(CHEMBL4445363)

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511558(CHEMBL4441668)

IC50: 1.20nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511541(CHEMBL4572668)

IC50: 1.30nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511550(CHEMBL4460022)

IC50: 1.5nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511553(CHEMBL4532667)

IC50: 1.60nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511561(CHEMBL4446044)

IC50: 2nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511562(CHEMBL4554146)

IC50: 2.10nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511569(CHEMBL4463639)

IC50: 2.30nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50522329(CHEMBL4452246)

IC50: 2.30nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511537(CHEMBL4470270)

IC50: 2.40nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50522329(CHEMBL4452246)

IC50: 2.5nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511563(CHEMBL4471663)

IC50: 2.5nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50522343(CHEMBL4453770)

IC50: 2.60nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511549(CHEMBL4518341)

IC50: 2.70nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511546(CHEMBL4553990)

IC50: 2.70nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511557(CHEMBL4544771)

IC50: 2.80nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50522351(CHEMBL4454164)

IC50: 2.80nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511538(CHEMBL4466701)

IC50: 3nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511548(CHEMBL4449082)

IC50: 3.10nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511543(CHEMBL4566625)

IC50: 3.10nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511540(CHEMBL4574717)

IC50: 3.20nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50522370(CHEMBL4533577)

IC50: 3.30nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50188594(CHEBI:62878 | CHEMBL1086580)

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3D Structure (crystal)

Poly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50511536(CHEMBL4585076)

IC50: 3.40nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 ARC5-SAM-PARP domain (613 to 1166 residues) expressed i...More data for this Ligand-Target Pair

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Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50522343(CHEMBL4453770)

IC50: 3.40nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

PDB Reactome pathway
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Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50511569(CHEMBL4463639)

IC50: 3.5nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50511553(CHEMBL4532667)

IC50: 3.70nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Poly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Riken

Curated by ChEMBL

BDBM50511567(CHEMBL4441063)

IC50: 3.80nMAssay Description:Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
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Details Article PubMed

Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511544(CHEMBL4445363)

IC50: 3.90nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...More data for this Ligand-Target Pair

PDB KEGG
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Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2(Homo sapiens (Human))
Japanese Foundation For Cancer Research

Curated by ChEMBL

BDBM50511552(CHEMBL4439372)

IC50: 3.90nMAssay Description:Inhibition of TNKS/TNKS2 (unknown origin) expressed in HEK293 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferase re...More data for this Ligand-Target Pair

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Displayed 1 to 50 (of 962 total ) | Next | Last >>

Filter my 962 hits

Targets 16▿
- Beta-3 adrenergic receptor 287
- Beta-1 adrenergic receptor 235
- Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2 132
- Poly [ADP-ribose] polymerase tankyrase-1 93
- Poly [ADP-ribose] polymerase tankyrase-2 93
- Beta-2 adrenergic receptor 66
- Poly [ADP-ribose] polymerase 1 37
- Protein mono-ADP-ribosyltransferase PARP10 6
- Poly [ADP-ribose] polymerase 2 6
- Cytochrome P450 1A2 1
- Cytochrome P450 2C9 1
- Cytochrome P450 2C19 1
- Cytochrome P450 2D6 1
- Cytochrome P450 2C8 1
- Cytochrome P450 2B6 1
- Cytochrome P450 3A4 1
- ...
Publications 9▿
- J Med Chem 62: 3407-3427 (2019) 214
- J Med Chem 63: 4183-4204 (2020) 160
- J Med Chem 52: 3063-72 (2009) 138
- J Med Chem 51: 4002-20 (2008) 126
- J Med Chem 51: 4804-22 (2008) 123
- J Med Chem 51: 1925-44 (2008) 97
- Bioorg Med Chem Lett 18: 5037-40 (2008) 47
- Bioorg Med Chem Lett 19: 4679-83 (2009) 29
- Bioorg Med Chem Lett 15: 251-4 (2004) 28
Institutions 4▿
- Astellas Pharma 560
- Riken 214
- Japanese Foundation For Cancer Research 160
- Fujisawa Pharmaceutical 28
Affinity: 0.029 to 1.0E+5 nM▿
- IC50 374
- EC50 588
- Affinity ≤ nM
Xtal structures: 8
Docked structures: 0
Catalog Cmpds: 9