Compile Data Set for Download or QSAR
maximum 50k data
Found 240 with Last Name = 'weaver' and Initial = 'df'
TargetHistamine H2 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609113(CHEMBL5276441)
Affinity DataKi:  2nMAssay Description:Antagonist activity at histamine H2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50609112(CHEMBL5273718)
Affinity DataKi:  26nMAssay Description:Antagonist activity at histamine H2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetHistamine H2 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM237183(Ranitidine)
Affinity DataKi:  89nMAssay Description:Antagonist activity at histamine H2 receptor (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetTranscription factor 4(Homo sapiens)TBA
LigandPNGBDBM50509813(CHEMBL4451478)
Affinity DataKi:  640nMAssay Description:Inhibition of beta catenin/Tcf4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTranscription factor 4(Homo sapiens)TBA
LigandPNGBDBM50094486(CHEMBL3589160)
Affinity DataKi:  7.60E+4nMAssay Description:Inhibition of beta catenin/Tcf4 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))TBA
LigandPNGBDBM24996(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))TBA
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50:  3nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))TBA
LigandPNGBDBM50609121(CHEMBL5276100)
Affinity DataIC50:  3nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM14774(3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM50609116(CHEMBL5280661)
Affinity DataIC50:  6nMAssay Description:Inhibition of caspase-3 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM15344(2-({2,3,5,6-tetrafluoro-4-[3-(trifluoromethoxy)phe...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human DHODHMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50:  9nMAssay Description:Inhibition Akt3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlutathione S-transferase Mu 2(Homo sapiens (Human))TBA
LigandPNGBDBM50609123(CHEMBL5275770)
Affinity DataIC50: <10nMAssay Description:Inhibition of human GSTM2-2 expressed in Escherichia coli assessed as inhibition by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50:  13nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))TBA
LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)
Affinity DataIC50:  13nMAssay Description:Inhibition Akt2 (unknown origin)More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))TBA
LigandPNGBDBM50310474(4-(1-cyclobutyl-5-methyl-1H-benzo[d]imidazol-2-yl)...)
Affinity DataIC50:  19nMAssay Description:Inhibition of p70S6 (unknown origin) at 1 uMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))TBA
LigandPNGBDBM50168576(3-(1-Ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-pyrazin-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50509623(CHEMBL4585089)
Affinity DataIC50:  21nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))TBA
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)
Affinity DataIC50:  24nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-3(Homo sapiens (Human))TBA
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  27nMAssay Description:Inhibition of caspase-3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50108504(4-(8-(benzo[c][1,2,5]oxadiazol-5-yl)-1,7-naphthyri...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50396763(CHEMBL2172374)
Affinity DataIC50:  34nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50287566(CHEMBL4160797 | US11572354, Compound 10m)
Affinity DataIC50:  34nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM14047(Aminofurazanyl-azabenzimidazole 6n | N-(3-{[2-(4-a...)
Affinity DataIC50:  35nMAssay Description:Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AK...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50287562(CHEMBL4173383 | US11572354, Compound 10e)
Affinity DataIC50:  38nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50365218(CHEMBL1956071 | GSK screening, 29)
Affinity DataIC50:  39nMAssay Description:Inhibition of N terminal histidine tagged human recombinant ROCK1 (3 to 543 residues) expressed in baculovirus infected Sf9 cells using biotin-Ahx-AK...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50396763(CHEMBL2172374)
Affinity DataIC50:  41nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-7(Homo sapiens (Human))TBA
LigandPNGBDBM50609116(CHEMBL5280661)
Affinity DataIC50:  42nMAssay Description:Inhibition of caspase-7 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50391772(CHEMBL2146851)
Affinity DataIC50:  42nMAssay Description:Inhibition of hERG (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))TBA
LigandPNGBDBM50609118(CHEMBL5282422)
Affinity DataIC50:  55nMAssay Description:Inhibition of MSK-1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50346088((1r,4r)-4-cyano-4-(3-(cyclopentyloxy)-4-methoxyphe...)
Affinity DataIC50:  63nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50235921(CHEMBL584991)
Affinity DataIC50:  67nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-1(Homo sapiens (Human))TBA
LigandPNGBDBM50609116(CHEMBL5280661)
Affinity DataIC50:  67nMAssay Description:Inhibition of caspase-1 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50465399(CHEMBL4291940)
Affinity DataIC50:  67nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50465399(CHEMBL4291940)
Affinity DataIC50:  69nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50:  73nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50529361(CHEMBL4515137 | US10988487, Example 52)
Affinity DataIC50:  81nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCaspase-7(Homo sapiens (Human))TBA
LigandPNGBDBM10246((4S)-4-{[(1S)-1-{[(2S)-1-carboxy-3-oxopropan-2-yl]...)
Affinity DataIC50:  87nMAssay Description:Inhibition of caspase-7 (unknown origin)More data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50562506(CHEMBL4791168)
Affinity DataIC50:  94nMAssay Description:Inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGlutathione S-transferase Mu 2(Homo sapiens (Human))TBA
LigandPNGBDBM50609124(CHEMBL5289652)
Affinity DataIC50:  100nMAssay Description:Inhibition of human GSTM2-2 expressed in Escherichia coli assessed as inhibition by fluorescence based analysisMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))TBA
LigandPNGBDBM24996(4-{1-ethyl-7-[(piperidin-4-ylamino)methyl]-1H-imid...)
Affinity DataIC50:  100nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))TBA
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  100nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM50287581(CHEMBL4173791 | US11572354, Compound 10d)
Affinity DataIC50:  100nMAssay Description:Inhibition of recombinant human IDO1 assessed as reduction in kynurenine production using L-tryptophan as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50609132(CHEMBL5278835)
Affinity DataIC50:  100nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
Displayed 1 to 50 (of 240 total ) | Next | Last >>
Jump to: