TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [125I]-CCL2 from human CCR2 expressed in U2OS cells incubated for 150 mins by scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataKi: 81.5nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 240nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 241nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 347nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 444nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 594nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 630nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 899nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 904nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 999nMAssay Description:Displacement of [3H]-CP55,940 from human CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.61E+3nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.70E+3nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.13E+3nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.54E+3nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 3.11E+3nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 4.62E+3nMAssay Description:Displacement of [3H]-CP55,940 from rat CB2 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 7.19E+3nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.11E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.17E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.35E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.51E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 1.94E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: 2.26E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from human CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-CP55,940 from rat CB1 receptor after 60 mins by microscintillation counting analysisMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 0.950nMAssay Description:Antagonist activity against human CCR2B expressed in Chem-1 cells assessed as inhibition of human CCL2-induced intracellular calcium flux incubated f...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 0.950nMAssay Description:Displacement of [3H]TAK-779 from CCR5 (unknown origin) after 120 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]RANTES from human CCR5 expressed in CHO cells after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Positive allosteric modulation of human CCR5 expressed in HEK293T cells co-expressing CAMYEL assessed as increase in CCL4-induced inhibition of forsk...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Antagonist activity against human CCR2B expressed in Chem-1 cells assessed as inhibition of human CCL2-induced intracellular calcium flux incubated f...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Antagonist activity at human CCR2b expressed in human Chem1 cells assessed as inhibition of human recombinant CCL2 induced Ca2+ mobilization preincub...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Displacement of [3H]INCB3344 from human CCR2 expressed in human U2OS cells after 120 mins by scintillation spectrometric analysisMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1S(Rattus norvegicus)
National Academy Of Sciences Of Ukraine
Curated by ChEMBL
National Academy Of Sciences Of Ukraine
Curated by ChEMBL
Affinity DataIC50: 87nMAssay Description:Competitive binding of 3[H]+isradipine to calcium channels of rat cardiac membranesMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Antagonist activity against human CCR2B expressed in Chem-1 cells assessed as inhibition of human CCL2-induced intracellular calcium flux incubated f...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of human CYP1B1 expressed in Escherichia coli DH5alpha coexpressing human NADPH P450 reductase using 7-ethoxyresorufin as substrate in pre...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 163nMAssay Description:Antagonist activity against human CCR2B expressed in Chem-1 cells assessed as inhibition of human CCL2-induced intracellular calcium flux incubated f...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 173nMAssay Description:Antagonist activity against human CCR2B expressed in Chem-1 cells assessed as inhibition of human CCL2-induced intracellular calcium flux incubated f...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Westf£Lische Wilhelms-Universit£T M£Nster
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Antagonist activity against human CCR2B expressed in Chem-1 cells assessed as inhibition of human CCL2-induced intracellular calcium flux incubated f...More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of cardiac phosphodiesterase-3 isolated from canine heart.More data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
The National Center For Drug Screening
Curated by ChEMBL
The National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlucagon-like peptide 1 receptor(Rattus norvegicus)
The National Center For Drug Screening
Curated by ChEMBL
The National Center For Drug Screening
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of [125I]GLP1 (7-36) amide binding to rat GLP1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of cardiac phosphodiesterase-3 isolated from canine heart.More data for this Ligand-Target Pair