Compile Data Set for Download or QSAR
maximum 50k data
Found 196 with Last Name = 'westhouse' and Initial = 'r'
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataKi:  116nMAssay Description:Inhibition of His-tagged BTK (unknown origin) after 1.5 hrs by HTRF analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataKi:  425nMAssay Description:Inhibition of His-tagged BTK (unknown origin) after 1.5 hrs by HTRF analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM166831(US10604504, Example 242 | US11623921, Example 242 ...)
Affinity DataIC50:  0.0700nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM165319(US10604504, Example 115 | US11623921, Example 115 ...)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297163(2-{8-Fluoro-3-[4-(2H3)methyl-1-methyl-1H-1,2,3-tri...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of BRD2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM445524(2-{7-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of BTK in human peripheral B cells assessed as reduction in CD86 surface expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of BTK in human PBMC assessed as reduction in TNFalpha expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM445527(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50579853(CHEMBL5075294)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM165320(US10604504, Example 116 | US11623921, Example 116 ...)
Affinity DataIC50:  0.520nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50579851(CHEMBL5084198)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50579852(CHEMBL5090513)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50566615(CHEMBL4846895)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM445528(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-6-fluoro-5-[...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM165463(US10604504, Example 141 | US11623921, Example 141 ...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM445524(2-{7-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM445515(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-9-fluoro-5-[...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50579853(CHEMBL5075294)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM445527(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297236(2-[3-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-methoxy-5-...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM165318(US10604504, Example 114 | US11623921, Example 114 ...)
Affinity DataIC50:  0.850nMAssay Description:Inhibition of recombinant human BTK using fluoresceinated peptide as substrate after 60 mins fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297163(2-{8-Fluoro-3-[4-(2H3)methyl-1-methyl-1H-1,2,3-tri...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Tec(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of TEC (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297070(5-{7-Methanesulfonyl-5-[(S)-oxan-4-yl(phenyl)methy...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50566615(CHEMBL4846895)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BRD4 (unknown origin) assessed as reduction in c-Myc expressionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM164638(BDBM166759 | US10604504, Example 223 | US11623921,...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BTK in human memory B cells assessed as reduction in CD86 surface expressionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50566614(CHEMBL4848871)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297163(2-{8-Fluoro-3-[4-(2H3)methyl-1-methyl-1H-1,2,3-tri...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
TargetNeurogenic locus notch homolog protein 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074796(CHEMBL3410169)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297144(2-[3-(Dimethyl-1H-1,2,3-triazol-5-yl)-9-methoxy-5-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMyc proto-oncogene protein(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM445527(2-[7-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-fluoro-5-[...)
Affinity DataIC50:  1nMAssay Description:Inhibition of c-MYC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50566614(CHEMBL4848871)
Affinity DataIC50:  1nMAssay Description:Inhibition of BRD4 (unknown origin) assessed as reduction in c-Myc expressionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50566613(CHEMBL4864173)
Affinity DataIC50:  1nMAssay Description:Inhibition of BRD4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeurogenic locus notch homolog protein 3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074771(CHEMBL3410153)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297162(2-{6-Fluoro-3-[4-(2H3)methyl-1-methyl-1H-1,2,3-tri...)
Affinity DataIC50:  1nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeurogenic locus notch homolog protein 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074818(CHEMBL3410163)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurogenic locus notch homolog protein 1(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074771(CHEMBL3410153)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch1 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurogenic locus notch homolog protein 3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074799(CHEMBL3410167)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurogenic locus notch homolog protein 3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074796(CHEMBL3410169)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeurogenic locus notch homolog protein 2(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074694(CHEMBL3410161)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch2 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50586606(CHEMBL5080354)
Affinity DataIC50:  1nMAssay Description:Inhibition of human BRD4 (1 to 477 residues) measured after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNeurogenic locus notch homolog protein 3(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM50074693(CHEMBL3410162)
Affinity DataIC50:  1nMAssay Description:Inhibition of Notch3 intracellular domain fragment transfected in human HeLa cells co-transfected with CBF1-PGL3 luciferase reporter vector by transa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Bristol Myers Squibb Research And Development

Curated by ChEMBL
LigandPNGBDBM297268(2-{6-Chloro-3-[4-(2H3)methyl-1-methyl-1H-1,2,3-tri...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human BRD4 (44 to 168 residues) expressed in Escherichia coli BL21 (DE3) incubated for 60 mins by TR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetBromodomain-containing protein 3(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM297146(2-{3-[4-(2H3)Methyl-1-methyl-1H-1,2,3-triazol-5-yl...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human BRD3 measured by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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