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Found 762 with Last Name = 'wilk' and Initial = 's'
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073602(CHEMBL3408973)
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50122293(CHEMBL401000 | CHEMBL63064 | N-(2,5-Dimethoxy-benz...)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073596(CHEMBL3408967)
Affinity DataKi:  0.310nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073597(CHEMBL3408968)
Affinity DataKi:  0.470nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073600(CHEMBL3408971)
Affinity DataKi:  0.670nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50229594(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Affinity DataKi:  0.700nMAssay Description:Inhibition of rat TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073598(CHEMBL3408969)
Affinity DataKi:  0.770nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073591(CHEMBL3408960)
Affinity DataKi:  0.860nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073588(CHEMBL3408974)
Affinity DataKi:  0.870nMAssay Description:Inhibition of TSPO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036831(6-Amino-2-mercapto-hexanoic acid | CHEMBL432852)
Affinity DataKi:  0.900nMAssay Description:Inhibition of arginylaminopeptidase (aminopeptidase B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073595(CHEMBL3408966)
Affinity DataKi:  0.990nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM11644((2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidi...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM11644((2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidi...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073603(CHEMBL3408963)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073599(CHEMBL3408970)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073592(CHEMBL3408961)
Affinity DataKi:  1.5nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073601(CHEMBL3408972)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM11645(2-{[8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dio...)
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073604(CHEMBL3408964)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073589(CHEMBL3408958)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073590(CHEMBL3408959)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50229594(CHEMBL253597 | N-(2-methoxybenzyl)-N-(4-phenoxypyr...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  3nMAssay Description:Inhibition of rat TSPOMore data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073593(CHEMBL3408962)
Affinity DataKi:  3nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM11645(2-{[8-(3-aminopiperidin-1-yl)-1,3-dimethyl-2,6-dio...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
TargetTranslocator protein(Rattus norvegicus (rat))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50073594(CHEMBL3408965)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H]PK11195 from TSPO in Wistar rat kidney mitochondrial fractions incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM11644((2S)-1-[(2S)-2-amino-2-cyclopentylacetyl]pyrrolidi...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranslocator protein(Homo sapiens (Human))
Stanford University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM22032(1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoq...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of human TSPOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM11642((2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-eth...)
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036829(2-Mercapto-4-methylsulfanyl-butyric acid | CHEMBL2...)
Affinity DataKi:  11nMAssay Description:Inhibition of arginylaminopeptidase (aminopeptidase B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM11642((2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-eth...)
Affinity DataKi:  12nM ΔG°:  -44.8kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM11643((2S,5R)-1-((2S)-2-amino-2-cyclopentylethanoyl)-5-p...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297454(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  30nMAssay Description:Inhibition of p38alpha by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036969((S)-2-Amino-pentane-1,5-dithiol | CHEMBL101771)
Affinity DataKi:  32nMAssay Description:Inhibitory potency was measured on aminopeptidase N (APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036827(CHEMBL27040 | [4-(2-Amino-3-mercapto-propyl)-cyclo...)
Affinity DataKi:  35nMAssay Description:Inhibition of aminopeptidase N (APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036968((S)-5-Amino-6-mercapto-hexanoic acid hydroxyamide ...)
Affinity DataKi:  37nMAssay Description:Inhibitory potency was measured on aminopeptidase N (APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase B(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036814(2-Mercapto-4-methyl-pentanoic acid | CHEMBL27010)
Affinity DataKi:  51nMAssay Description:Inhibition of arginylaminopeptidase (aminopeptidase B)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Rattus norvegicus (rat))
Abbott Laboratories

LigandPNGBDBM11643((2S,5R)-1-((2S)-2-amino-2-cyclopentylethanoyl)-5-p...)
Affinity DataKi:  56nM ΔG°:  -41.0kJ/molepH: 7.5 T: 2°CAssay Description:The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  70nMAssay Description:Inhibition of JNK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297455(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  90nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297456(6-bromo-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)m...)
Affinity DataKi:  100nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036824((S)-3-Carboxy-1-mercaptomethyl-propyl-ammonium | (...)
Affinity DataKi:  120nMAssay Description:Inhibition of aminopeptidase N (APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAminopeptidase N(Sus scrofa (Pig))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036824((S)-3-Carboxy-1-mercaptomethyl-propyl-ammonium | (...)
Affinity DataKi:  120nMAssay Description:Inhibitory potency was measured on aminopeptidase N (APN)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036962((S)-4-Carboxy-1-mercaptomethyl-butyl-ammonium | (S...)
Affinity DataKi:  130nMAssay Description:Inihibitionof aminopeptidase A (APA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
The University Of Mississippi

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]mesulergine form human cloned 5HT2C receptor expressed in african green monkey COS7 cells by scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036824((S)-3-Carboxy-1-mercaptomethyl-propyl-ammonium | (...)
Affinity DataKi:  140nMAssay Description:Inhibition of aminopeptidase A (APA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamyl aminopeptidase(Homo sapiens (Human))
University Of Paris

Curated by ChEMBL
LigandPNGBDBM50036824((S)-3-Carboxy-1-mercaptomethyl-propyl-ammonium | (...)
Affinity DataKi:  140nMAssay Description:Inihibitionof aminopeptidase A (APA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297457(1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)methyl)-3...)
Affinity DataKi:  140nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297458((Z)-methyl 1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-y...)
Affinity DataKi:  160nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50297459(4-bromo-1-((6-fluoro-4H-benzo[d][1,3]dioxin-8-yl)m...)
Affinity DataKi:  185nMAssay Description:Inhibition of JNK3 by spectrophotometric coupled enzyme assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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